1. Anti-cancer effects of hydro-alcoholic extract of pericarp of pistachio fruits
Hamidreza HARANDI ; Ahmad MAJD ; Soudeh Khanamani FALAHATI-POUR ; Mehdi MAHMOODI ; Mehdi MAHMOODI
Asian Pacific Journal of Tropical Biomedicine 2018;8(12):598-603
Objective: To investigate the cytotoxicity and anti-cancer effects of hydro-alcoholic extract of pistachio pericarp on hepatocellular carcinoma cells (HepG2) and mouse fibroblast L929 cells as normal and control group cell. Methods: MTT assay was performed to investigate the cytotoxicity effects of the extract at 0-4 000 μg/mL on the cells after 24 and 48 h. The expressions of some genes involved in apoptosis including Bax, Bcl-2 and P53 were investigated by real time PCR. Results: Our results showed that after 24 and 48 hours of treatment of cells with this extract, the viability of HepG2 and L929 cells was reduced. Therefore, this extract had the cytotoxicity effect on both cells. The IC
2. Trigonella foenum-graecum seed extract modulates expression of lipid metabolism-related genes in HepG2 cells
Maryam MOHAMMAD-SADEGHIPOUR ; Mehdi MAHMOODI ; Mohammad FAHMIDEHKAR ; Mohammad MIRZAEI ; Mojgan KARIMABAD ; Mohammad HAJIZADEH ; Maryam MOHAMMAD-SADEGHIPOUR ; Mehdi MAHMOODI ; Mohammad MIRZAEI ; Mojgan KARIMABAD ; Mohammad HAJIZADEH ; Mehdi MAHMOODI ; Soudeh FALAHATI-POUR ; Alireza KHOSHDEL ; Mohammad FAHMIDEHKAR
Asian Pacific Journal of Tropical Biomedicine 2019;9(6):240-248
Objective: To investigate anti-dyslipidemic effects of hydroalcoholic fenugreek seed extracts, diosgenin, and 4-OH-Ile on HepG2 cell line. Methods: HepG2 cells were treated with hydroalcoholic fenugreek seed extracts, diosgenin, 4-OH-Ile, and orlistat. IC
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