1.Comedogenicity of ten commonly-used cosmetic oils using the modified mills and kligman skin surface biopsy on adult skin of color Filipinos, a double-blind controlled trial
Sophia Vivien L. Verallo ; Vermé ; n Verallo-Rowell
Journal of the Philippine Dermatological Society 2024;33(Suppl 1):41-42
BACKGROUND
Comedogenicity is the potential to promote follicular blockage leading to the formation of microcomedones and cosmetic acne. Mills and Kligman compared the established rabbit ear assay (REA) ratings with studies in human participants using the skin surface biopsy. They concluded that some materials considered comedogenic on REA were non-comedogenic in human skin.
OBJECTIVEUsing a modification of the Mills and Kligman skin surface biopsy, this study aimed to determine the comedogenic potential of ten commonly used cosmetic oils: almond oil, argan oil, avocado oil, castor oil, coconut oil, grape seed oil, mineral oil, olive oil, safflower oil, and sunflower oil.
METHODSEach participant received a test patch with twelve chambers on the skin of the back, with each chamber containing filter paper saturated with each of the respective oils, the positive control (octyl palmitate), and the negative control (unsaturated filter paper). These patches were changed 3 times weekly for 4 weeks. Cyanoacrylate skin surface biopsies were done to determine the number of follicles and microcomedones at baseline and after 4 weeks of exposure.
RESULTSThirty individuals were enrolled in the study. All participants underwent baseline and final skin surface biopsies. Almond oil showed a significant increase with a 112.9% increase in the number of comedones from baseline.
CONCLUSIONThe results of this study show that certain oils commonly used as ingredients in cosmetic products, such as almond oil, are comedogenic.
Human ; Oils
2.A case of alopecia areata with ophiasis in a 31-year-old Filipino female
Sophia Vivien L. Verallo ; Maria Jasmin J. Jamora
Journal of the Philippine Dermatological Society 2024;33(Suppl 1):8-8
Alopecia areata with ophiasis has a worldwide prevalence of only 0.02%. In the last ten years, only 10 cases have been reported in the Philippines. This variant is often resistant to treatment. Novel therapeutic options are being explored, although these are frequently limited to case reports due to the rarity of the disease. Newer therapies, such as JAKSTAT inhibitors and monoclonal antibodies, show promise as effective options for ophiasis-type alopecia areata.
Human ; Female ; Adult: 25-44 Yrs Old ; Alopecia Areata ; Baricitinib