1.Investigation of basement membrane proteins in a case of granular cell ameloblastoma.
Puangwan LAPTHANASUPKUL ; Sopee POOMSAWAT ; Jira CHINDASOMBATJAROEN
International Journal of Oral Science 2012;4(1):45-49
Granular cell ameloblastoma is a rare, benign neoplasm of the odontogenic epithelium. A case of massive granular cell ameloblastoma in a 44-year-old Thai female is reported. Histopathological features displayed a follicular type of ameloblastoma with an accumulation of granular cells residing within the tumor follicles. After treatment by partial mandibulectomy, the patient showed a good prognosis without recurrence in a 2-year follow-up. To characterize the granular cells in ameloblastoma, we examined the expression of basement membrane (BM) proteins, including collagen type IV, laminins 1 and 5 and fibronectin using immunohistochemistry. Except for the granular cells, the tumor cells demonstrated a similar expression of BM proteins compared to follicular and plexiform ameloblastomas in our previous study, whereas the granular cells showed strong positivity to laminins 1 and 5 and fibronectin. The increased fibronectin expression in granular cells suggests a possibility of age-related transformation of granular cells in ameloblastoma.
Adult
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Ameloblastoma
;
chemistry
;
pathology
;
Basement Membrane
;
chemistry
;
Cell Adhesion Molecules
;
analysis
;
Collagen Type IV
;
analysis
;
Female
;
Fibronectins
;
analysis
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Humans
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Keratinocytes
;
chemistry
;
pathology
;
Laminin
;
analysis
;
Mandibular Neoplasms
;
chemistry
;
pathology
;
Membrane Proteins
;
analysis