It is well known that total colonoscopy is one of the essential procedure to make diagnosis of colonic and terminal ileal diseases, to detect early atage of colonic cancer and to do prophylactic removal of premalignant polyp. Previously commonly used longer colonoscope has been reached to ileocecal area with patients much discomfort arising from excessive loop formation at sigmoid or transverse colon because of no limitation of the length. (continue...)
Colon ; Colon, Sigmoid ; Colon, Transverse ; Colonic Neoplasms ; Colonoscopes ; Colonoscopy ; Diagnosis ; Humans ; Ileal Diseases ; Polyps

This study was carried out to understand the relationship between specific chromosome changes and their phenotypic consequences at the tissue level of human lung cancers. Then paraffin-embedded human lung squamous cell carcinoma samples were investigated for in evidence of genetic alterations, using chromosome 7 and 17-specific repetitive alpha-satellite DNA probes. In situ hybridization procedure with chromosome-specific DNA probes was optimized for use on formalin-fixed paraffin-embedded lung tissue sections. The chromosome index ranged from 1.10 to 1.88(median, 1.49) for chromosome 7 and 1.20 to 1.98(median, 1.69) for chromosome 17. Normal lymphocytes and stromal cells showed one or two chromosome signals per cell in most cases. All tumors showed three or more chromosome signals per cell with range of 16.0% to 80.6% of cancer cells(median, 50.9%) for chromosome 7 and 32.7% to 84.7%(median, 69.9%) for chromosome 17. The chromosome index did not correlate with the DNA content in most cases. Chromosomes 7 and 17 were either overrepresented or underrepresented when they were compared with corresponding DNA index determined by FCM. An increase in copy number, particularly of chromosome 7 was associated with a less favorable phenotype, including high nuclear grade. In addition, chromosome alterations were differentially expressed in the different areas of the same tissue section, correlating with histologic heterogeneity. These results suggest that chromosome polysomy can be reliably detected in tissue sections using in situ hybridization. There is a strong correlation between genotypic abnormalities and tumor phenotype in human lung cancer. This capability will prove to be an important tool for determining the underlying genetic basis for tumor development, tissue phenotype heterogeneity and progression by allowing genetic determination to be made on paraffin-embedded tissue sections where tumor histologic architecture is preserved.
Humans ; Lung Neoplasms

The presense of the esophageal varices might have a partial machanical obstruction and cushion effect on esophageal lumen due to blood within the varices. It may affect on the motility and acid clearance in the esophagus. The aim of this study was to evaluate the acid clearance and the esophageal motility according to the degree of the varices in patients with esophageal varices. We have performed esophageal manometry and acid clearance test in 41 patients with esophageal varices. Esophageal motility disorder was abserved in 29.4% of patients with esophageal varices. The number of swallowing for acid clearance was significantly increased in patients with esophageal varices than control group(23.5 +/- 14.1 Vs 6.1 +/- 1.6, p=0.004). However, there was no significant corelation with form, location, and redcolor sign of the varices. In conclusion, patients with esophageal varices accompanied esophageal motility disorders and delayed acid clearance. This results might be a useful referance data for changes in esophageal motility before and after treatment of esophageal varices.
Deglutition ; Esophageal and Gastric Varices* ; Esophageal Motility Disorders ; Esophagus ; Humans ; Manometry ; Varicose Veins

This study aims to investigate visual tracking task of Koreans to the various visual stimuli by measuring the horizontal saccadic reaction times. The measuring system consists of eye monitor using infra-red reflection technique, oscillographic recorder and forehead-chin fixation devices. The visual stimuli generated by target function generator displayed simple-step, pulsestep and double-step stimulus patterns. The results revealed that the sacoadic reaction time showed no significant changes between the size of target displacement within horizontal 20 degrees. Furthermore, no significant changes between the particular direction of stimulus could be found. The nominal value of reaction time was 259 +/- 25 msec.
Reaction Time

Epithelial-myoepithelial carcinoma of intercalated duct(origin) is a recently described tumor characterized by its typical biphasic pattern of central duct like cell and peripheral clear cell. We described a case of epithelial-myoepithelial carcinoma in a 10-year-old boy. Microscopically, the tumor showed typical biphasic pattern, diffuse proliferation of clear cells and linining epithelial cells of tubular structures. Immunohistochemically, the clear cell showed positive reaction to S-100 protein, and the epithelial cells expressed cytokeratin indicating myoepithelial and epithelial differentiation respectively. Biphasic differentiation of the tumor cells could be also proved by electronmicroscopic study.

No abstract available.
Gastric Mucosa* ; Helicobacter pylori* ; Helicobacter*

BACKGROUND: The concept of frailty has been extended to include social factors such as poverty and social support networks. The frailty index developed for elderly Canadians was recently examined in terms of the current broader concept of frailty. The present study explored the relationship between social support networks and frailty in Korean elderly individuals aged 65 years or older. METHODS: A total of 1,874 people aged 65 years or older were recruited by judgment sampling of the population of Seocho-gu in Seoul and surveyed in 2011. The Korean Frailty Index, developed by the Korean Geriatric Society, was used as an outcome variable. A proportional odds model was used to evaluate the relationship between social support networks and depressive symptoms. RESULTS: The prevalence of frailty and pre-frailty were 7.7% and 25.5%, respectively. A total of 9.9% of older adults lacked a social network, and 13.6% were deficient in social support. Social support networks were associated with frailty. Adjusting for sociodemographic factors (age, sex, marital status, economic status, and education), lack of a social network and support were associated with increased odds of frailty (social network: odds ratio 2.15, 95% confidence interval 1.58-2.92; social support: odds ratio 2.01, 95% confidence interval 1.54-2.63). CONCLUSION: Consistent with the concept of frailty being broadened to include social factors, frailty among elderly individuals was found to be influenced by social support networks.
Adult ; Aged ; Humans ; Judgment ; Marital Status ; Odds Ratio ; Poverty ; Prevalence

A clinical observation was made on 412 cases of diabetes mellitus who were admitted to Eul Ji General Hospital, Seoul, Korea, during the period from January 1980 to June 1983 with regard to urogenital compilations. The results were as follows: 1. The incidence rate of urogenital complications among 412 cases of D.M. was found in 21.1% (87 cases). 2. Concerning the frequency of genitourinary complications (87 cases) in each disease, urinary infection was found in 70 cases (80.5%), nephrotic syndrome in 7cases (8%), Kimmelstiel-Wilson syndrome in 5 cases (5.8%), neurogenic bladder in 3 cases (3.4%). 3. The most .frequent age distribution of urogenital complications of D.M. showed more than 50 years of age with 75% (65 cases). 4. The longer the duration of the diabetes was, the higher the incidence rate of urogenital complications. 5. Complications of D.M. except genitourinary tract were hypertension; 18.5%, pulmonary T.B.; 11.9%, retinopathy 10.4%, respiratory infection; 6.1%, neuropathy; 5.8%.
Age Distribution ; Diabetes Mellitus* ; Diabetic Nephropathies ; Hospitals, General ; Hypertension ; Incidence ; Korea ; Nephrotic Syndrome ; Seoul ; Urinary Bladder, Neurogenic

BACKGROUND: Verifying the effect of frailty on health-related quality of life may help us better understand the impact of frailty. The present study explored the relationship between frailty and health-related quality of life in community-dwelling Korean elderly. METHODS: Older adults aged 65 years or older recruited by judgment sampling of the population of Seocho-gu in Seoul were surveyed in 2011. The Korean frailty index measure developed by the Korean Geriatric Society was used as the outcome variable. Proportional odds model was used to evaluate the relationship between health-related quality of life (HRQoL) and frailty. RESULTS: We found that, after adjusting for sociodemographic covariates, being prefrail or frail significantly increased the proportional odds for lowering health-related quality of life than being nonfrail. In addition, of the five components of health-related quality of life, the magnitude of the adverse effects of frailty on HRQoL was largest for pain/discomfort, with anxiety/depression being the second largest. CONCLUSION: Compared to persons who are not frail, older Korean individuals identified as frail and prefrail exhibit significantly lower HRQoL scores. This association between Korean frailty measures and the generic measure of the HRQoL may offer new information to better understand frailty within its broader context.
Adult ; Aged ; Humans ; Judgment ; Quality of Life

We experienced three young patients with diffuse lymphoid hyperplasia of the gastric antrum. The peculiar nodularity of the stomach in tliese patients is another cause of etat mammelanne in addition to hypertrophic gastritis and prominence of the areae gastricae. The etiology of the diffuse lymphoid hyperplasia of the gastric antrum is not known. The symptqm is not specific and not related to hitologic and gastroscopic finding but rather to psychological disturbance. We propose longstanding observation for the change of the nodularity.
Gastritis, Hypertrophic ; Humans ; Hyperplasia ; Pyloric Antrum* ; Stomach