1.The pritchard ERS elbow prosthesis in rheumatoid arthritis.
Jung Man KIM ; Yong Sik KIM ; Soon Yong KWON
The Journal of the Korean Orthopaedic Association 1991;26(1):90-95
No abstract available.
Arthritis, Rheumatoid*
;
Elbow Prosthesis*
;
Elbow*
2.A Cytogenetic Study of Amenorrhea.
Kyung Soon LEE ; Jung Ho HAN ; Shin Yong MOON
Korean Journal of Fertility and Sterility 1999;26(3):467-474
OBJECTIVEs: Cytogenetic investigations were carried out on 770 women with primary (n=560) and secondary amenorrhea (n=210) to determine the frequency of chromosomal or genetic causes of amenorrhea. MATERIALS AND METHODS: In 770 women with primary amenorrhea (n=560) and secondary amenorrhea (n=210), chromosomal analysis were performed. RESULTS: 1) The most prevalent age group is 16-20 years of age group with primary amenorrhea and 26-30 years of age group with secondary amenorrhea. 2) Out of 560 cases of primary amenorrhea, 343 cases (61.3%) had the normal chromosome constitution and 217 cases (38.7%) had the abnormal chromosome constitution including 46,XY. 3) In 217 cases of abnormal chromosome of primary amenorrhea, 57 cases (26.3%) had 45,X and 34 cases (15.8%) had the 46,XY, 24 cases (11.0%) had 45,X/46,X,i (Xq), 23 cases (10.6%) had 45,X/46,X,+mar and 14 cases (6.6%) had 45,X/46,XY. 4) Out of 210 cases of secondary amenorrhea, 181 cases (86.2%) had the normal chromosome constitution and 29 cases (13.8%) had 45,X/46,XX. CONCLUSION: High percentage of chromosomal abnormalities was diagnosed in primary amenorrhea and most of them were sex chromosome anomalies. In secondary amenorrhea, the prevalence was lower than primary amenorrhea, so a preselection of patients with secondary amenorrhea for cytogenetic investigations seems to be necessary.
Amenorrhea*
;
Chromosome Aberrations
;
Constitution and Bylaws
;
Cytogenetics*
;
Female
;
Humans
;
Prevalence
;
Sex Chromosomes
3.p53 Protein Expression in Infiltrating Ductal Carcinoma of the Breast.
Soon Hee JUNG ; Mee Yon CHO ; Soo Yong KIM
Korean Journal of Pathology 1996;30(1):7-14
Overexpression of the nuclear phosphoprotein p53 is the most common genetic anomaly found in primary human cancer and mutation of the tumor suppressor gene p53 has been identified in breast cancer cell lines. In this study, we evaluated the prognostic significance of p53 protein expression in patients with mammary infiltrating ductal carcinoma and its correlation with histopathologic grade, lymph node status, tumor size, p53 protein expression and survival. Among 53 cases, p53 protein expression was detected in 26(49.1%) cases by immunohistochemistry. There was no correlation between p53 protein overexpression and histopathologic grade(p=0.09) or lymph node status(p=0.38) and between survival and histopathologic grade (p=0.68) or lymph node status(p=0.52). However, p53 protein expression was significantly correlated with survival(p=0.01) and patients with p53 protein-positive tumors showed poorer survival times. But Cox multivariate analysis showed the lymph node status is significant(p=0.01). The authors conclude that the presence of mutant p53 protein and lymph node status may serve a prognostic role, in a subset of mammary infiltrating ductal carcinoma cases.
Humans
;
Genes, Tumor Suppressor
;
Breast Neoplasms
4.Anthelmintic effect of oxantel and oxantel/pyrantel tablets against intestinal nematode infections.
Soon Hyung LEE ; Chul Yong SONG ; Jung Kyoo LIM
The Korean Journal of Parasitology 1977;15(2):121-126
Present trial was carried out to evaluate the anthelmintic efficacy of oxantel/pyrantel tablets against intestinal nematode infections, and to determine the efficacy of oxantel tablels against Trichuris infection. A total of 34 subjects with the mixed infections were treated with oxantel/pyrantel tablets (100 mg/tablet each) in a single dose of 15 mg/kg body weight, and another group of 22 Trichuris infected cases received oxantel pamoate tablets (125 mg/tablet) in a single dose of 15 mg/kg. All stool examinations were done before the treatment and 3 weeks after the treatment. The cellophane thick smear (Kato's technique) and Stoll's dilution egg counting method were employed. The results of the trial were summarized as follows: The cure rates (egg negative conversion rates) and egg reduction rates for oxantel/pyrantel tablets were 85.3 percent and 97 percent in trichuriasis, 100 percent each in ascariasis and ancylostomiasis. The oxantel tablet treated group demonstrated a cure rate of 90.9 percent and an egg reduction rate of 96.3 percent in the treatment of Trichuris. There were no detectable objective and subjective side effects in this trial. Both oxantel/pyrantel and oxantel pamoate tablets were readily accepted and well tolerated.
parasitology-helminth-nematoda
;
Enterobius vermicularis
;
Ancylostoma duodenale
;
Trichuris trichiura
;
chemotherapy-oxantel/pyrante
;
oxantel pamoate
5.A case of Patau syndrome with holoprosencephaly.
Jung Keum PARK ; Tae Gyu HWANG ; Soon Yong LEE
Journal of the Korean Child Neurology Society 1993;1(2):137-143
No abstract available.
Holoprosencephaly*
6.A clinical analysis of incisional hernia.
Phil Soon PARK ; Yong Hwan JUNG ; Kun Pil CHOI
Journal of the Korean Surgical Society 1993;44(6):1029-1037
No abstract available.
Hernia*
7.Differences in thrombolytic effects in accordance with dosing- resimens of tissue- type plasminogen activator in experimental pulmonary embolism.
Hee Soon CHUNG ; Ho Jung KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1993;40(2):123-134
No abstract available.
Plasminogen Activators*
;
Plasminogen*
;
Pulmonary Embolism*
8.Complications of patellar component in total knee arthroplasty.
Jung Man KIM ; Soon Yong KWON ; Young Joong KIM
The Journal of the Korean Orthopaedic Association 1993;28(2):540-546
No abstract available.
Arthroplasty*
;
Knee*
9.Transpedicular Zielke Instrumentation for the Spondylolisthesis: Result of 73 Cases
Jae Yoon CHUNG ; Yong Ho JUNG ; Hyung Soon KIM
The Journal of the Korean Orthopaedic Association 1990;25(3):933-940
Although several kinds of instrumentation systems are available for the transpedicular screw fixation in the treatment of spondylolisthesis, the clinical results and the difference between them remdins unclear. In order to study the feasibility of Zielke instrumentation system for that purpose, the author analysed the clinical results of 73 patients with mild or moderate degree of spondylolisthesis who were instrumented with the systems and followed up 25 months in average(Min. 12Ms). The results between the groups with different rod thickness in the system, 3.2mm(20 patients), 4mm(33 patients) and 5mm(20 patients), were compared to study the most appropriate thickness. Reduction of the deformity were done by aid of temporarilly applied Harrington system in 3.2mm group. Inlayed reduction potential coming from the jointing mechanism was utilized in the cases with less than 30% of slippage in 4 and 5mm group. Percentage of slippage was changed from 20% preoperatively, to 4% postoperatively and 6% at the end of follow up. The methods of fusion after reduction and fixation were anterior in 25 and posterolateral in 48. Bony fusion was achieved in all but one with pathological spondylolisthesis. Rod failures were observed in two of 3.2mm and one of 4mm group, and loosening of the joint were developed in three of 5mm group. Clinically, 93% of the patient showed excellent and good results at the end of follow up. From the results, we concluded that the instrumentation is a efficient method of treatment with several advantages in the reduction capacity and the stability of fixation. However, this system has several points in its mechanics that needs to be improved.
Congenital Abnormalities
;
Follow-Up Studies
;
Humans
;
Joints
;
Mechanics
;
Methods
;
Spondylolisthesis
10.Effect of Synovectomy on Prognsis of Rheumatoid Arthritis
Jung Man KIM ; Soon Yong KWON ; Jong Hoon PARK
The Journal of the Korean Orthopaedic Association 1994;29(1):213-222
This is a long term follow-up study to clarify whether arthroscopic synovectomy would be able to prevent further destruction of the articular cartilage in rheumatoid joints. Three hundred and eighteen rheumatoid joints of 94 patients who had surgery in the multiple joints(average 3.4 joints per person) and was followed for an average 39.9 months (range, 24-126 months) were selected. Diagnosis of rheumatoid arthritis was made according to the 1987 revised criteria of the American College of Rheumatology. The preoperative roentgenographic narrowing of cartilage space (modified classification of ARA) and the arthroscopic findings (grading of Outerbridge) were recorded. The points of investigation were 1) further destruction of articular cartilage on X-ray, postoperatively, and 2) reaccumulation of effusion. The results were as follows; 1) Knee Joint: Among 103 knee joints there were 92 (89.3%) Stage I, G-0 knees, 8 Stage II (G-2: 1, G-3: 3, G-4: 4 joints), and 3 Stage IIIB, G-4, preoperatively. The 3 Stage IIIB, G-4 knees showed progression of narrowing of joint space and were replaced by artificial joints two years after the synovectomy. 2) Wrist joint: Fifteen joints (28.3%) out of 53 joints were Stage II, G-4, and 2 joints joints (3.8%) were Stage I, G-3, preoperatively. They were progressed to Stage IIIB at final follow-up. 3) Other Joints: There was no further narrowing of the joint space following surgery in 22 fingers, 2 toes, 34 elbows, 34 shoulders and 70 ankles. 4) Prognosis seemed to depend upon postoperative medication. From these results it would be suggested that the rate and severity of recurrence of synovitis and further destruction of articular cartilage can be decreased with early synovectomy so long as proper anti-rheumatic medication is followed, although the surgery can not halt the disease process.
Ankle
;
Arthritis, Rheumatoid
;
Cartilage
;
Cartilage, Articular
;
Classification
;
Diagnosis
;
Elbow
;
Fingers
;
Follow-Up Studies
;
Humans
;
Joints
;
Knee
;
Knee Joint
;
Prognosis
;
Recurrence
;
Rheumatology
;
Shoulder
;
Synovitis
;
Toes
;
Wrist Joint