No abstract available.
Hyperlipidemias* ; Tarsal Tunnel Syndrome*

Tumor lysis syndrome (TLS) defines the metabolic derangements that occur with tumor breakdown following the initiation of cytotoxic therapy. TLS results from the rapid destruction of malignant cells and the abrupt release of intracellular materials and their metabolites into the extracellular space. The syndrome causes hyperuricemia, hyperkalemia, hyperphosphatemia, secondary hypocalcemia and uremia. It can result in acute renal failure and be fatal. Early recognition of patient at risk and preventive measures are important. There is a high incidence of TLS in tumors with high proliferative rates and large burden such as acute lymphoblastic leukemia and Burkitt's lymphoma. It less commonly occurs in solid tumors such as testicular cancer, breast cancer and small cell lung cancer. There are only a few reports on TLS complicated in CML in blast crisis. So we report a 45-yr-old woman presenting with TLS associated with CML in lymphoblastic crisis after the initiation of cytotoxic chemotherapy.
Acute Kidney Injury ; Blast Crisis ; Breast Neoplasms ; Burkitt Lymphoma ; Drug Therapy ; Extracellular Space ; Female ; Humans ; Hyperkalemia ; Hyperphosphatemia ; Hyperuricemia ; Hypocalcemia ; Incidence ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Small Cell Lung Carcinoma ; Testicular Neoplasms ; Tumor Lysis Syndrome* ; Uremia

BACKGROUND AND OBJECTIVES: Previous studies have suggested that women with AMI are less aggressively managed than men. The aim of this study was to assess the differences between the sexes, in terms of the medical and invasive coronary procedures, in AMI patients during the 1990s, and the association to in-hospital mortality. SUBJECTS AND METHODS: In 1758 AMI patients, the baseline clinical characteristics, initial management and in-hospital outcomes, were studied. RESULTS: The women, on average, were older than men (68.8+/-10.6 versus 59.2+/-12.3, p<0.01), with a higher prevalence of diabetes and hypertension. Women received heparin and b-blockers less often than men. The unadjusted rates of thrombolysis, angiography and PTCA use were lower in women than men, but not after covariate adjustment. The in-hospital mortality was higher in women than men (11.7% versus 8.1%, odd ratio (OR) 1.51, 95% CI 1.09 to 2.11, p<0.05), but this difference was not significant after adjustment for age (adjusted OR 0.98, 95% CI 0.69 to 1.40, p=NS). CONCLUSION: Women with AMI are less aggressively managed than men, and have higher in-hospital mortalities. The difference in outcome seems to be associated with increased age, with a greater co-morbidity of women.
Angiography ; Female ; Heparin ; Hospital Mortality ; Humans ; Hypertension ; Male ; Mortality ; Myocardial Infarction* ; Prevalence ; Sex Characteristics*