1.Linar Scleroderma: Report of Three Cases.
Korean Journal of Dermatology 1971;9(3):65-69
Three cases of linear scleroderma with typical clinical and histopathological findings were presented. Case 1: A 10 year old female had a "coupe de sabre" type of linear scleroderma on the right side of the frontal scalp and face and hemiatrophy of the right side of the face. Case 2: A 10 year old female had a type of scleroderma en bande on the palm and dorsum of the left hand and clubbed finger of the left third finger. Case 3: A 21 year old male had a linear type of skin atrophy and sclerosis of the right lower exteremity and mild walking disturbance.
Atrophy
;
Child
;
Female
;
Fingers
;
Hand
;
Humans
;
Male
;
Osteoarthropathy, Secondary Hypertrophic
;
Scalp
;
Scleroderma, Localized
;
Sclerosis
;
Skin
;
Walking
;
Young Adult
2.Linar Scleroderma: Report of Three Cases.
Korean Journal of Dermatology 1971;9(3):65-69
Three cases of linear scleroderma with typical clinical and histopathological findings were presented. Case 1: A 10 year old female had a "coupe de sabre" type of linear scleroderma on the right side of the frontal scalp and face and hemiatrophy of the right side of the face. Case 2: A 10 year old female had a type of scleroderma en bande on the palm and dorsum of the left hand and clubbed finger of the left third finger. Case 3: A 21 year old male had a linear type of skin atrophy and sclerosis of the right lower exteremity and mild walking disturbance.
Atrophy
;
Child
;
Female
;
Fingers
;
Hand
;
Humans
;
Male
;
Osteoarthropathy, Secondary Hypertrophic
;
Scalp
;
Scleroderma, Localized
;
Sclerosis
;
Skin
;
Walking
;
Young Adult
3.A Case of Hereditary Spherocytosis.
Eui Lim CHOI ; Chul Hwan PARK ; Tae Gyu HWANG ; In Soon PARK ; Soon Yong LEE
Journal of the Korean Pediatric Society 1983;26(11):1120-1124
No abstract available.
4.Comparison of D-PUVA with Conventional PUVA in the Treatment of Korean Psoriasis Patients.
Byung Soon PARK ; Hi Tae AN ; Jai Il YOUN
Korean Journal of Dermatology 1998;36(2):275-279
BACKGROUND: PUVA photochemotherapy has been accepted as an effective mode of treatment for psoriasis. Many combination therapies have been tried to reduce the possible adverse effects of long-term exposure to UV radiation. OBJECTIVE: This study was performed to compare calcipotriol-PUVA combination therapy(D-PUVA) with conventional PUVA in the treatment of Korean psoriasis patients. METHODS: We treated 38 Korean psoriasis patients with conventional PUVA and 12 with D-PUVA. We compared the total number, duration and total UVA dose of PUVA therapy to reach grade 4 between the two groups. We categorized each patient into clearing, improvement, or failure groups based on the therapeutic efficacy, and measured the PASI score at each of the patients visits. RESULTS: The total cumulative dose of D-PUVA phototherapy was significantly smaller than PUVA phototherapy. CONCLUSION: Combining PUVA with a vitamin D analogue, calcipotriol, in the treatment of psoriasis may lead to lowering the risk of long-term exposure to UV radiation with higher efficacy.
Humans
;
Photochemotherapy
;
Phototherapy
;
Psoriasis*
;
PUVA Therapy
;
Vitamin D
5.Assessment of Vascularization within Hydroxyapatite Ocular Implant by Bone Scintigraphy: Comparative Analysis of Planar and SPECT Imaging.
Seok Tae LIM ; Myung Hee SOHN ; Soon Ah PARK
Korean Journal of Nuclear Medicine 1999;33(6):475-483
PURPOSE: Complete fibrovascular ingrowth within the hydroxyapatite ocular implant is necessary for peg drilling which is performed to prevent infection and to provide motility to the ocular prosthesis. We compared planar bone scintigraphy and SPECT for the evaluation of the vascularization within hydroxyapatite ocular implants. MATERIALS AND METHODS: Seventeen patients (M:F=12:5, mean age: 50.4+/-17.5 years) who had received a coralline hydroxyapatite ocular implant after enucleation surgery were enrolled. Patients underwent Tc-99m MDP planar bone and SPECT imaging by dual head gamma camera after their implant surgery (interval: 197+/-81 days). Uptake on planar and SPECT images was graded visually as less than (grade 1), equal to (grade 2), and greater than (grade 3) nasal bridge activity. Quantitative ratio of implanted to non-implanted intraorbital activity was also measured. Vascularization within hydroxyapatite implants was confirmed by slit lamp examination and ocular movement. RESULTS: All but three patients were considered to be vascularized within hydroxyapatite implants. In visual analysis of planar image and SPECT, grade 1 was noted in 9/18 (50%) and 6/18 (33%), respectively. Grade 2 pattern was 7/18 (39%) and 4/18 (22%), and grade 3 pattern was 2/18 (11%) and 8/18 (44%) respectively. When grade 2 or 3 was considered to be positive for vascularization, the sensitivity of planar and SPECT imaging were 60% (9/15) and 80% (12/15), respectively. In 3 patients with incomplete vascularization, both planar and SPECT showed grade 1 uptake. The orbital activity ratios on planar imaging were not significantly different between complete and incomplete vascularization (1.96+/-0.87 vs 1.17+/-0.08, p>0.05), however, it was significantly higher on SPECT in patients with complete vascularization (8.44+/-5.45 vs 2.20+/-0.87, p<0.05). CONCLUSION: In the assessment of fibrovascular ingrowth within ocular implants by Tc-99m MDP bone scintigraphy, SPECT image appears to be more effective than planar scintigraphy.
Durapatite*
;
Eye, Artificial
;
Gamma Cameras
;
Head
;
Humans
;
Orbit
;
Radionuclide Imaging*
;
Technetium Tc 99m Medronate
;
Tomography, Emission-Computed, Single-Photon*
6.Hydrochlorothiazide-induced phototoxic reaction.
Jin Soon KANG ; Tae Heung KIM ; Ki Beom PARK
Korean Journal of Dermatology 1992;30(4):529-534
A 49-year-old male had erythematous to rusky red papules, indurated plaques and lichenified patches with hyperpigmentation on sun-exposed areas for 6 years. Phototest revealed the decreased rninimal erythemal dose to UVA(10J/cm. Photopatch test with 5% Trandate ointment, 5% hydrochlorthiazide ointment and vaselin. as a control were all negative. Two weeks after cessation of Trandate, an oral challenge of hydrochlorthiazide followed by phototest was perfrirmed resulting in exacerbation of skin lesions and photosensitivity with a decreased MED to UVA(10J/cm) again. After the cesation of Trandate containing hydrochlorthiazide, the skin lesions were improved with complete loss of photosensitivity. But, improvement of the infiltrated or licheified plaques were delayed. Presenile cataract previously noted in the patient seemed to be related to his longstanding intake of hydrochlorthiazide.
Cataract
;
Humans
;
Hyperpigmentation
;
Labetalol
;
Male
;
Middle Aged
;
Skin
7.Tc-99m ECD Brain SPECT in Patients with Traumatic Brain Injury : Evaluating Distribution of Hypoperfusion and Assesment of Cognitive and Behavioral Impairment in Relation to Thalamic Hypoperfusion.
Soon Ae PARK ; Suk Tae LIM ; Myung Hee SON
Korean Journal of Nuclear Medicine 2000;34(6):445-455
PURPOSE: We evaluated the distribution of hypoperfusion in patients with traumatic brain injury (TBI) and the relationship of thalamic hypoperfusion to severity of cognitive and behavioral sequelae. MATERIALS AND METHODS: Tc-99m ECD SPECT and MRI were performed in 103 patients (M/F=81/22, mean age 34.7+/-15.4 yrs) from 0.5 to 55 months (mean 10.3 months) after TBI. The patients were divided into three groups showing no abnormalities (G1), focal (G2) and diffuse injury (G3) on MRI. Psychometric tests assessed 11 cognitive or behavioral items. In all patients, we evaluated the distribution of hypoperfused areas in SPECT, and in 57/103 patients, neuropsychological (NP) abnormalities in patients with thalamic hypoperfusion were compared with those of patients without thalamic hypoperfusion. RESULTS: The perfusion deficits were most frequently located in the frontal lobe (G1, 42.3%: G2 34.5%: G3 33.3%), temporal lobe (24~26%) thalami (21~22.4%), parietal and occipital lobe (< or =10%). Numbers of NP abnormalities in the cases of cortical hypoperfusion with or without concomitant thalamic hypoperfusion were following: the former 4.7+/-1.5 and the latter 3.2+/-1.4 in G1, 5.0+/-1.1 and 4.8+/-1.2 in G2, 6.8+/-1.8 and 6.3+/-1.1 in G3, respectively. This difference according to thalamic hypoperfusion was significant in G1 (p=0.002), but was not significant in G2 or G3. CONCLUSION: SPECT in patients with TBI had demonstrated hypoperfusion mostly involving the frontal, temporal and thalami. In normal group on MRI, frontal hypoperfusion was more prominent than that of any other group, Furthermore in this group, SPECT could predict severity of NP outcome by concomitant thalamic hypoperfusion with cerebral cortical abnormalities.
Brain Injuries*
;
Brain*
;
Equidae*
;
Frontal Lobe
;
Humans
;
Magnetic Resonance Imaging
;
Occipital Lobe
;
Perfusion
;
Psychometrics
;
Rabeprazole
;
Temporal Lobe
;
Tomography, Emission-Computed, Single-Photon*
8.A case of Patau syndrome with holoprosencephaly.
Jung Keum PARK ; Tae Gyu HWANG ; Soon Yong LEE
Journal of the Korean Child Neurology Society 1993;1(2):137-143
No abstract available.
Holoprosencephaly*
10.Inhibitory control of angiotensin-converting enzyme by ramipril in migraine
Hyun-Jung Park ; Soon-Tae Lee ; Manho Kim
Neurology Asia 2013;18(3):289-291
Background: Renin-angiotensin systems (RAS) are involved in the physiology of migraine. Ramipril
is an angiotensin-converting enzyme inhibitor. We tested whether ramipril has an effect on migraine.
Methods: The study was designed as a prospective open-labeled trial in a single center. All patients
were asked to maintain a headache diary. Ramipril was administered at 5mg/day (2.5mg twice a day)
and subjects were checked every 4 weeks up to 12 weeks. Results: The mean number of headache
days was 19.9 ± 11.2 days per month at baseline, and 12.0 ± 11.5 at 12 weeks (p<0.001 vs. baseline)
with a responder rate of 41.9%. Stratified analysis by migraine frequency (15 days a month > vs. <15
days a month) did not show a difference. Mean blood pressure was not altered.
Conclusions: Ramipril prevented migraine attacks independently from blood pressure. This result
supports a link between renin-angiotensin system and migraine pathophysiology (Clinicaltrials.gov
identifier: NCT01402479).