1.A Case of Mollaret Meningitis.
Yong Joo KIM ; Soon Sup JANG ; In Joon SEOL
Journal of the Korean Pediatric Society 1988;31(9):1193-1196
No abstract available.
Meningitis*
2.A Case of Holoprosencephaly.
Byung Chun SUH ; Soon Sup JANG ; In Joon SEOL ; Soo Jee MOON ; Chong Moo PARK ; Seok Chol JEON
Journal of the Korean Pediatric Society 1987;30(6):695-700
No abstract available.
Holoprosencephaly*
3.A Case of Emphysematous Pyelonephritis.
Jang Sup YOON ; Hyon Woo HWANG ; Sang Soon SOHN ; Tchun Yong LEE
Korean Journal of Urology 1986;27(5):738-742
Emphysematous pyelonephritis is a rare, life-endangering suppurative infection of the renal parenchyma and perirenal tissues. The disease is encountered mainly in the diabetic patient with or without ureteral obstruction and is characterized by the production of intrarenal and occasionally, perirenal gas. We report a case of emphysematous pyelonephritis, treated by left nephrectomy, in 55-year-old diabetic woman.
Female
;
Humans
;
Middle Aged
;
Nephrectomy
;
Pyelonephritis*
;
Ureteral Obstruction
4.A Statistical Study of the Children with Congenital Heart Diseases confirmed by Cardiac Catheterization and Cineangiography.
Jeong Kook LEE ; Hang Bo CHO ; Soo Yup LEE ; In Joon SEOL ; Kyoo Whan RHEE ; Chong Moo PARK ; Sung Oh KIM ; Soon Sup JANG
Journal of the Korean Pediatric Society 1988;31(2):153-160
No abstract available.
Cardiac Catheterization*
;
Cardiac Catheters*
;
Child*
;
Cineangiography*
;
Heart Diseases*
;
Heart*
;
Humans
;
Statistics as Topic*
5.A Case of Potter Syndrome Syndrome Accompanied with Partial Agenesis of Corpus Callosum.
Soon Sup JANG ; Byung Chun SUH ; Kyoo Hwan RHEE ; Soo Jee MOON ; Keun Soo LEE ; Byung Tae PARK ; Eun Kyung HONG
Journal of the Korean Pediatric Society 1987;30(11):1287-1293
No abstract available.
Agenesis of Corpus Callosum*
6.A review of subacute necrotizing lymphadenitis.
Chang Hoon JANG ; Soon Seog KWON ; Young Kyoon KIM ; Kwon Hyoung KIM ; Ki Don HAN ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK
Tuberculosis and Respiratory Diseases 1991;38(3):297-303
No abstract available.
Lymphadenitis*
7.Relationship of airway remodeling with clinical characteristics in bronchial asthma.
Sook Young LEE ; Jae Soon JANG ; Soon Seog KWON ; Young Kyoon KIM ; Kwan Hyoung KIM ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK
Journal of Asthma, Allergy and Clinical Immunology 2001;21(3):517-524
BACKGROUND: We observed airway remodeling, which is the thickness of the susepithelial layer, in asthmatic patients and inhealthy subjects in order to determine its relationship with severity of disease, such as symptom, bronchial hyperresponsiveness, and degree of acute exacerbation. Moreover, for evaluation of factors contributing to airway remodeling, we analyzed the age, sex, presence of atopy, length of asthmatic history and degree of airway inflammation. METHODS: Thirty-six patients with asthma and ten healthy controls were recruited for the study. The degree of asthma symptom severity was assessed using NIH criteria. Bronchial responsiveness to methacholine was expressed as provocative concentration of methacholine causing a 20% fall in FEV1. The degree of acute exacerbation was assessed by PaCO2 during acute exacerbation. Bronchoscopy, bronchoalveolar lavage(BAL), and bronchial biopsy were performed for all subjects; the total cell counts, differential cell counts and levels of ECP were measured in BAL fluid, and the basement membrane thickness and degree of epithelial shedding were measured in biopsy samples under light microscopy. RESULTS: The mean values of basement membrane thickness were 7.8+/-0.6 micrometer in asthmatics, and 4.1+/-0.5 micrometer in healthy subjects (p<0.05). Basement membrane thickness in patients with severe persistent asthma differed significantly from that of patients with mild intermittent asthma (11.8+/-1.0 micrometer vs 6.5+/-0.7 micrometer p<0.05). A lower level of PC20 for methacholine was observed in asthma with thick basement membrane(> or =7.5 micrometer) compared to those with base- ment membrane less than 7.5micrometer (0.26+/-0.13 mg/ml vs. 0.74+/-0.16 mg/ml, p<0.05). No difference was found between the degree of thickening in patients with different degree of acute exacerbation with age, sex, atopy and lengths of asthmatic history. The degree of thickening was positively correlated to degree of epithelial shedding (r=0.393, p<0.05), but not to the degree of total cell counts, differential cell percentage nor ECP in BAL fluid. CONCLUSION: We confirmed that thickening of the basement membrane is a characteristic finding of asthma. We also demonstrated that it affects symptom severity and bronchial hyperresponsiveness, and is related to degree of epithelial damage rather than duration of asthma history.
Airway Remodeling*
;
Asthma*
;
Basement Membrane
;
Biopsy
;
Bronchoscopy
;
Cell Count
;
Humans
;
Inflammation
;
Membranes
;
Methacholine Chloride
;
Microscopy
8.Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication.
Yu Mi LEE ; Kyu Chan HUH ; Soon Man YOON ; Byung Ik JANG ; Jeong Eun SHIN ; Hoon Sup KOO ; Yunho JUNG ; Sae Hee KIM ; Hee Seok MOON ; Seung Woo LEE
Gut and Liver 2016;10(2):250-254
BACKGROUND/AIMS: To determine the incidence and clinical characteristics of tuberculosis (TB) medication-associated Clostridium difficile infection. METHODS: This multicenter study included patients from eight tertiary hospitals enrolled from 2008 to 2013. A retrospective analysis was conducted to identify the clinical features of C. difficile infection in patients who received TB medication. RESULTS: C. difficile infection developed in 54 of the 19,080 patients prescribed TB medication, representing a total incidence of infection of 2.83 cases per 1,000 adults. Fifty-one of the 54 patients (94.4%) were treated with rifampin. The patients were usually treated with oral metronidazole, which produced improvement in 47 of the 54 patients (87%). Twenty-three patients clinically improved with continuous rifampin therapy for C. difficile infection. There were no significant differences in improvement between patients treated continuously (n=21) and patients in whom treatment was discontinued (n=26). CONCLUSIONS: The incidence of C. difficile infection after TB medication was not low considering the relatively low TB medication dosage compared to other antibiotics. It may not be always necessary to discontinue TB medication. Instead, decisions concerning discontinuation of TB medication should be based on TB status.
Adult
;
Aged
;
Aged, 80 and over
;
Anti-Infective Agents/therapeutic use
;
Antibiotics, Antitubercular/*adverse effects
;
*Clostridium difficile
;
Enterocolitis, Pseudomembranous/chemically induced/drug therapy/*epidemiology
;
Female
;
Humans
;
Incidence
;
Male
;
Metronidazole/therapeutic use
;
Middle Aged
;
Retrospective Studies
;
Rifampin/*adverse effects
;
Treatment Outcome
;
Tuberculosis/*drug therapy
9.Three cases of extensive liver metastasis in neuroendocrine tumors.
Eui Ju PARK ; Seong Ran JEON ; Dae Yong KIM ; Jae Young JANG ; Jung Hoon KIM ; So Young JIN ; Chan Sup SHIM
Korean Journal of Medicine 2009;76(Suppl 1):S15-S21
Malignant neuroendocrine tumors have the histological features of malignant tumors, and localized invasion and distant metastasis can occur. After clinical presentation, patients with neuroendocrine tumors usually show rapid deterioration. The first case involved a patient who underwent treatment for poorly differentiated adenocarcinoma of the lung. A percutaneous liver biopsy was performed to look for diffuse infiltration of the tumor in the liver. As a result, the patient was diagnosed with large-cell neuroendocrine carcinoma of the lung with diffuse liver metastasis. The other two patients presented with liver masses. Liver biopsies revealed metastatic neuroendocrine tumors of the liver. In patients presenting with diffuse hepatic infiltration of a tumor, a neuroendocrine tumor should be considered in the diagnosis, and immunohistochemical staining and further studies should be performed to locate the origin of the tumor. We report three cases of neuroendocrine tumors with diffuse liver metastasis.
Adenocarcinoma
;
Biopsy
;
Carcinoma, Neuroendocrine
;
Humans
;
Liver
;
Lung
;
Neoplasm Metastasis
;
Neuroendocrine Tumors
10.A Phase II Trial of Haptaplatin/5-FU and Leucovorin for Advanced Stomach Cancer.
Won Sup LEE ; Gyeong Won LEE ; Hwal Woong KIM ; Ok Jae LEE ; Young Joon LEE ; Gyung Hyuck KO ; Jong Seok LEE ; Joung Soon JANG ; Woo Song HA
Cancer Research and Treatment 2005;37(4):208-211
PURPOSE: Heptaplatin (SKI-2053 R) is a new platinum analogue, with a better toxicity profile than cisplatin, and has antitumor activity even in cisplatin resistant cell lines. 5-fluoruracil (5-FU) has shown synergy with platinum compounds. This phase II trial was designed to determine the efficacy and toxicities of heptaplatin/ 5-FU (5-fluorouracil) for treating stomach cancer. MATERIALS AND METHODS: Thirty-two patients with advanced, measurable gastric adenocarcinomas were enrolled in this trial. The treatment consisted of heptaplatin, 400 mg/m2/day (1 hour IV infusion), on day 1 and 5-FU, 800 mg/m2/day (12 hours IV infusion), on days 1 to 5. The cycles were repeated every 3 weeks. RESULTS: Of the 26 evaluable patients, 9 had partial responses and 1a complete response (overall response rate, 38%; 95% confidence interval, 19~57%). The median response duration was 23 weeks (range: 4~60 weeks). The median time to progression was 26 weeks (range: 3~68 weeks). The grades III-IV toxicities were mostly hematological toxicities: leucopenia was observed in 11 patients (35%) and thrombocytopenia 4 (13%). No definite neuropathy was observed. Grade I-II nephropathy was also noted: grade I high BUN/creatinine levels occurred in 5 patients (16%), grade II proteinuria 2 (6%), grade I proteinuria 5 (16%). Neutropenic fever developed in 5 patients (16%) and 1 died of pneumonia in a neutropenic state. CONCLUSION: This study suggests that the regimen of Heptaplatin/5-FU should be effective and have a favorable toxicity profile for the patients suffering with advanced stomach cancer.
Adenocarcinoma
;
Cell Line
;
Cisplatin
;
Drug Therapy
;
Fever
;
Fluorouracil
;
Humans
;
Leucovorin*
;
Platinum
;
Platinum Compounds
;
Pneumonia
;
Proteinuria
;
Stomach Neoplasms*
;
Stomach*
;
Thrombocytopenia