1.A case of adenomatous tumor of the middle ear.
Joon KWON ; Joong Wha KOH ; Soon Il PARK ; Soon Hee JEONG ; Ki Yeun KIM ; Seog In PAIK
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(6):1322-1327
No abstract available.
Ear, Middle*
2.New Guidelines for Asthma Management.
Korean Journal of Medicine 2014;87(2):156-162
Asthma is a chronic airway inflammatory disease that is characterized by symptoms such as shortness of breath, wheezing, chest tightness, and nighttime or early morning coughing, together with variable expiratory airflow limitation. Asthma is a heterogeneous disease involving various underlying processes that have been described based on causal or exacerbating factors, the pattern of airflow obstruction, severity of disease, pattern of cellular inflammation, and structural changes among patients with asthma. However, there is considerable overlap among these clinical variants, which are not correlated strongly with specific pathological processes or treatment responses. The Global Strategy for Asthma Management and Prevention 2014 (GINNA 2014) emphasizes the importance of confirming the diagnosis to minimize both under- and over-treatment with respect to the heterogeneity of asthma. To assess asthma control, it is necessary to assess not only the symptom control but also the future risks of an adverse outcome. Lung function is the most used indicator of future risk. This article reviews the treatment of adult asthma, including patients already receiving treatment according to GINA 2014 and the Health Insurance Review and Assessment Service.
Adult
;
Asthma*
;
Cough
;
Diagnosis
;
Dyspnea
;
Humans
;
Inflammation
;
Insurance, Health
;
Lung
;
Pathologic Processes
;
Population Characteristics
;
Pulmonary Ventilation
;
Respiratory Function Tests
;
Respiratory Sounds
;
Thorax
3.The Effects of Intradermal Vaccination with DNA Encoding for the T-cell Receptor on the Induction of Experimental Autoimmune Encephalomyelitis in B10.PL Mice.
Soon Seog KWON ; Nachsung KIM ; Tae June YOO
Journal of Korean Medical Science 2005;20(6):1039-1045
Intradermal gene administration was found to induce a more profound immune response than direct intramusclular gene injection. We performed intradermal vaccination of B10.PL mice with DNA encoding for the V 8.2 region of the T-cell receptors (TCR). Three weeks later, these mice were immunized with rat myelin basic protein (MBP). Daily mean clinical scores and mortality rate were lower in this group compared with controls. The proliferative responses of lymph node cells to rat MBP were slightly less in the vaccination groups than in the control groups (p<0.05). However, we detected no differences between the two groups with regard to the production of MBP-specific IgG, IgG1, & IgG2a antibodies. The levels of cytokine mRNA expression in the vaccination groups were observed higher than in the control groups without antigen-specific stimulation, but all of cytokine expressions between the vaccination and control groups after antigen-specific stimulation were identical. These results demonstrate that intradermal DNA vaccines encoding for TCR might prove to be useful in the control of autoimmune disease.
Animals
;
Autoantibodies/blood
;
Base Sequence
;
Cytokines/genetics
;
DNA, Complementary/genetics
;
Encephalomyelitis, Autoimmune, Experimental/etiology/immunology/*prevention and control
;
Female
;
Gene Expression
;
*Genes, T-Cell Receptor beta
;
In Vitro
;
Injections, Intradermal
;
Lymphocyte Activation
;
Mice
;
Myelin Basic Proteins/immunology
;
RNA, Messenger/genetics/metabolism
;
Rats
;
Research Support, N.I.H., Extramural
;
Research Support, Non-U.S. Gov't
;
Vaccines, DNA/*administration and dosage/genetics
4.A review of subacute necrotizing lymphadenitis.
Chang Hoon JANG ; Soon Seog KWON ; Young Kyoon KIM ; Kwon Hyoung KIM ; Ki Don HAN ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK
Tuberculosis and Respiratory Diseases 1991;38(3):297-303
No abstract available.
Lymphadenitis*
5.Continuous Positive Airway Pressure Therapy in a Obstructive SleepApnea Syndrome associated with Active Acromegaly.
Hwa Sik MOON ; Young Mee CHOI ; Seog Ju AHN ; Chi Hong KIM ; Soon Seog KWON ; Young Kyoon KIM ; Kwan Hyoung KIM ; Jeong Sup SONG ; Sung Hak PARK
Tuberculosis and Respiratory Diseases 1995;42(4):610-617
Sleep apnea occurs in approximately 50% of patients with acromegaly, and sleep apnea is associated with increased cardiovascular diseases and mortality. In view of these findings, sleep apnea may be a factor in the increased incidence of cardiovascular deaths in acromegaly patients. We experienced a case of active acromegaly patient, 54-yr-old man, associated with obstructive sleep apnea syndrome, congestive heart failure with dilated cardiomyopathy and serious cardiac arrhythmias. He was treated for obstructive sleep apnea syndrome, diagnosed by overnight polysomnography, with nasal continuous positive airway pressure(CPAP) for 4 months, which successfully controlled his loud snoring, sleep apnea, nocturnal hypoxemia and apnea-related symptoms. And also he was treated for underlying acromegaly and cardiac complications with bromocriptine and cardiogenic drugs for 4 months, but still had elevated growth hormone(GH) and insulin like growth factor-1 (IGF-1) levels and serious cardiac arrhythmias. We describe our experience about the effect of CPAP treatment in an active acromegaly patient associated with obstructive sleep apnea syndrome and cardiac complications with review of literature.
Acromegaly*
;
Anoxia
;
Arrhythmias, Cardiac
;
Bromocriptine
;
Cardiomyopathy, Dilated
;
Cardiovascular Diseases
;
Continuous Positive Airway Pressure*
;
Heart Failure
;
Humans
;
Incidence
;
Insulin
;
Mortality
;
Polysomnography
;
Sleep Apnea Syndromes
;
Sleep Apnea, Obstructive
;
Snoring
6.The change of peripheral eosinophil count after bronchial provocati-on with inhaled histamine in bronchial asthmatics.
Chi Hong KIM ; Young Kyoon KIM ; Soon Seog KWON ; Kwan Hyoung KIM ; Ki Don HAN ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK
Tuberculosis and Respiratory Diseases 1992;39(5):386-391
No abstract available.
Eosinophils*
;
Histamine*
7.Determination of the Activity of Pulmonary Tuberculosis: the Utility of High-Resolution Computed Tomography.
Myung Hee CHUNG ; Hae Giu LEE ; Won Jong YU ; Hong Jun CHUNG ; Bo Sung YANG ; Soon Suck KWON ; Seog Hee PARK
Journal of the Korean Radiological Society 2000;42(5):757-764
PURPOSE: To evaluate the utility of high-resolution computed tomography(HRCT), as used to determine the activity of tuberculosis, and to analyze the HRCT findings in active and in inactive tuberculosis. MATERIALS AND METHODS: We analyzed the HRCT findings of 100 patients (54 men, 46 women; average age, 54 years) who according to the results of chest radiography had pulmonary tuberculosis of undetermined activity. We assessed HRCT findings such as the presence of a entrilobular, macro-, or micronodule; consolidation, ground-glass opacity, cavity, interlobular septal thickening, irregular linear opacities, bronchial wall thickening, bronchovascular bundle distortion, bronchiectasis, atelectasis, and pericicatrical emphysema. We compared the ratio of the area of nodule and consolidation to that of whole lung, and compared the findings between active and inactive tuberculosis. RESULTS: Eleven of 100 patients were excluded because the final diagnosis was other than tuberculosis. In 59 patients, the presence of active pulmonary tuberculosis was proven by positive sputum smear and/or culture for Mycobacterium tuberculosis. On the basis of the negative results of these tests, pulmonary tuberculosis was found to be inactive in 30 patients; serial chest radiographs indicated that their condition remained stable over a 6-month period. For HRCT, sensitivity was 96.6%, specificity 56.7%, positive predictive value 81.4%, negative predictive value 89.5%, and accuracy 83.1%. For active tuberculosis, the presence of centrilobular nodules, tree-in-bud, macronodules, cavity within the nodule, and consolidations was statistically significant, while for inactive tuberculosis, that of irregular linear opacities, micronodules, bronchiectasis, and cicatrization atelectasis was similarly significant. The CT score for the area of nodules and consolidations was higher in active than in inactive tuberculosis, but only the nodule score showed statistical significance. CONCLUSION: HRCT can be a useful diagnostic tool for evaluating the activity of pulmonary tuberculosis
Bronchiectasis
;
Cicatrix
;
Diagnosis
;
Emphysema
;
Female
;
Humans
;
Lung
;
Male
;
Mycobacterium tuberculosis
;
Pulmonary Atelectasis
;
Radiography
;
Radiography, Thoracic
;
Sensitivity and Specificity
;
Sputum
;
Thorax
;
Tuberculosis
;
Tuberculosis, Pulmonary*
8.A case of inflammatory pseudotumor completely resolved by steroid therapy.
Seung Ho BANG ; Chi Hong KIM ; Soon Seog KWON ; Young Kyoon KIM ; Kwan Hyoung KIM ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK
Tuberculosis and Respiratory Diseases 1993;40(6):709-713
No abstract available.
Granuloma, Plasma Cell*
9.A case of bronchial web.
Si Hyun BAE ; Chi Hong KIM ; Young Kyoon KIM ; Soon Seog KWON ; Kwan Hyoung KIM ; Ki Don HAN ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK
Tuberculosis and Respiratory Diseases 1992;39(2):176-179
No abstract available.
10.Right ventricular ejection fraction using ECG-Gated first pass cardioangiography.
Young Hee MOON ; Hae Giu LEE ; Sung Min LEE ; Soo Kyo CHUNG ; Jeong Ik YIM ; Yong Whee BAHK ; Kyung Sub SHINN ; Young Gyun KIM ; Soon Seog KWON
Korean Journal of Nuclear Medicine 1993;27(1):135-139
No abstract available.
Stroke Volume*