1.A Case of Lupus Vulgaris Followed by Miliary Tuberculosis.
Soon Nam SOH ; Yoo Jung HWANG ; Jae Hong KIM ; Joong Hwan KIM
Annals of Dermatology 1990;2(2):125-127
No abstract available.
Lupus Vulgaris*
;
Tuberculosis, Miliary*
2.Epidemiological Treatment for Postgonococcal Urethritis in Uncomplicated Male Gonococcal Urethritis.
Soon Nam SOH ; Joong Hwan KIM ; Young Tae KIM ; Jae Hong KIM
Korean Journal of Dermatology 1990;28(1):34-38
An important concern in treatment for gonorrhea is the high frequency of coexisting chlarnydial and gonococcal infections. But there is difficulty in the diagnosing chlamydial infection. And so, CDC recommends epidemiological treatment, of both gonorrhea and non-gonococcal urethritis in the gonorrheal treatment in order to prevent post-gonococcal urethritis(PGU), A total of 140 male patients with uncomplicated gonococcal urethritis at the VD clinic, Choong-ku Publir. Health Center, in Seoul during December, 1987 February, 1988 were subjected to this study. The patients treated with kanamycin(KM), 2g and aqueous penicillin G(ACPG) 8 million units imaccompanied by probenecid(BEN) 1g by mouth. This combination regimen showed good effect in the treatment of gonococcal urethritis (failure rate 4.2% ). After gonorrheal treatment, the patients were divided randomly into group A and group B. In the group A, adminstrated with doxycycline monohydrate, 100mg, by mouth two times daily for 7 days, 44 and 29 patients were followed at 7th and 14th day after gonorrheal treatment. In the group B, administrated with placebo, 1 tablet, by mouth two times daily for 7 days, 49 and 39 patients were followed at 7th and 14th day after gonorrheal treatment. The PGU incidences were 27.3%(12/44), 20.7%(6,'29) in the group A and 55. 1%(27,'49), 53.8(21/39) in the group B at 7th and 14th day after gonorrheal treatment. Conclusively, eoncornitant administration of doxycycline monohydrate, 100mg, by mouth two times daily for 7 days with gonorrheal treatment lowered PGU significantly.
Centers for Disease Control and Prevention (U.S.)
;
Doxycycline
;
Gonorrhea
;
Humans
;
Incidence
;
Male*
;
Mouth
;
Penicillins
;
Seoul
;
Urethritis*
3.Treatment of uncomplicated male gonococcal urethritis with enoxacin.
Joong Hwan KIM ; Hong Yoon YANG ; Soon Nam SOH ; Hae Seung PAIK ; Yoo Jung HWANG ; Ji Hyun KIM ; Young Tae KIM ; Jae Hong KIM
Korean Journal of Dermatology 1991;29(6):795-800
No abstract available.
Enoxacin*
;
Humans
;
Male*
;
Urethritis*
4.Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells.
Young Ran PARK ; Jae Soon EUN ; Hwa Jung CHOI ; Manoj NEPAL ; Dae Keun KIM ; Seung Yong SEO ; Rihua LI ; Woo Sung MOON ; Nam Pyo CHO ; Sung Dae CHO ; Tae Sung BAE ; Byung Il KIM ; Yunjo SOH
The Korean Journal of Physiology and Pharmacology 2009;13(6):417-424
Osteoclasts, derived from multipotent myeloid progenitor cells, play homeostatic roles in skeletal modeling and remodeling, but may also destroy bone in pathological conditions such as osteoporosis and rheumatoid arthritis. Osteoclast development depends critically on a differentiation factor, the receptor activator of NF-kappaB ligand (RANKL). In this study, we found that the hexane soluble fraction of the common fig Ficus carica (HF6-FC) is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW264.7 cells and in bone marrow-derived macrophages (BMMs). HF6-FC exerts its inhibitory effects by suppression of p38 and NF-kappaB but activation of ERK. In addition, HF6-FC significantly decreased the expression of NFATc1 and c-Fos, the master regulator of osteoclast differentiation. The data indicate that components of HF6-FC may have therapeutic effects on bone-destructive processes such as osteoporosis, rheumatoid arthritis, and periodontal bone resorption.
Arthritis, Rheumatoid
;
Bone Resorption
;
Carica
;
Ficus
;
Macrophages
;
Myeloid Progenitor Cells
;
NF-kappa B
;
Osteoclasts
;
Osteoporosis
;
Receptor Activator of Nuclear Factor-kappa B