1.Asia's first successful minimally invasive transapical transcatheter mitral valve-in-valve implantation.
Jia Lin SOON ; Yeow Leng CHUA ; Victor Tt CHAO ; Paul Tl CHIAM ; See Hooi EWE ; Ving Yuen SEETHO ; Chung Yin LEE ; Swee Yaw TAN ; Tian Hai KOH ; Kenny Yk SIN
Annals of the Academy of Medicine, Singapore 2013;42(2):85-87
2.Resistant hypertension during antituberculosis treatment: how is rifampicin implicated?
Soon Leng Lee ; Wei Juan Lim ; Shu Teng Chai
The Medical Journal of Malaysia 2020;75(5):591-593
smear-positive pulmonary tuberculosis. His backgroundhistory included chronic essential hypertension which waswell-controlled with amlodipine 10mg daily. However, hisblood pressure became suboptimal one week intoantitubercular treatment, necessitating escalation ofantihypertensive therapy up to six medications. Followingcompletion of antitubercular treatment, his blood pressureimproved markedly. The number of antihypertensives wasable to be reduced to only two after a month. We postulatethat rifampicin has attenuated the therapeutic effect ofamlodipine via potent induction of hepatic CYP3A4 but thefailure to control the blood pressure even with medicationsunrelated to cytochrome P450 pathways raises the spectreof an additional interaction.
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