The purpose of this study was to analyse the magnetic resonance (MR) appearance of the patellar tendon autograft for anterior cruciate ligament injury. Among 35 patients of ACL reconstructions with central 1/3 of the patellar tendon autograft and interference screw fixation, 13 patients underwent MRI examination. All examination were performed on 1.5 T magnet(Signa;GE medical system). T1WI, PDI, T2WI Sagittal and coronal images were obtained together with T2WI MPGR and oblique sagittal images. A four-level grading system based on the MR appearance of the ACL graft was developed. A grade I was indiscernible in graft course, Grade II; incomplete in its course, grade III; complete but thin and grade IV; complete and thick. 2 out of 13 patients showed grade I, 3; grade II, 4; grade III and 4 grade IV. Five patients of grade I and II had a finding of roof impingement. However, only one out of 8 grade III and IV revealed such finding. In summary reconstructed ACL had various appearance in MRI, which was considered to be closely related with roof impingement.
Anterior Cruciate Ligament ; Autografts ; Humans ; Magnetic Resonance Imaging ; Patellar Ligament ; Transplants

No abstract available.

We studied the association of nonspecific bronchial hyperresponsiveness with general characteristics, exposure concentration, respiratory symptoms, chest x-ray findings, past histories and pulmonary function. We determined bronchial hyperresponsiveness by methacholine challenge test. And we conducted a respiratory symptom questionnaire and performed spirometry on 111 workers occupationally exposed to isocyanates in various industries. About 21.6% of subjects had bronchial hyperresponsiveness. No significant differences were observed between the hyperresponsive and non-responsive group with respect to age, sex, employment period, height, and smoking histories cough and breathlessness were significantly associated with the bronchial hyperresponsiveness. The hyperresponsive group had more experience of bronchitis and asthma in the past than the non-responsive group. The lower FEV1 and FEV1 % were closely related with bronchial hyperresponsiveness. Bronchial hyperrespoosiveness seems to be associated with some of respiratory symptoms, past histories and pulmonary function parameters in workers exposed to isocyanates.
Asthma ; Bronchitis ; Cough ; Employment ; Isocyanates* ; Methacholine Chloride ; Occupations ; Surveys and Questionnaires ; Smoke ; Smoking ; Spirometry ; Thorax

The present experiments were conducted to evaluate the effects of follicular fluid on maturation of bovine follicular oocytes. TC medium 199 seemed to be in adequate for this purpose since a high proportion (ranging 84.1. to 97.0%) of the oocytes were able to resume meiotic division in both media-with or without the addition of follicular fluid. This implies a possible similarity between TC medium 199 and follicular fluid with regard to the components initiating meiosis. Actually, TC medium 199 contains amino acids, vitamins and carbohydrates most of which are also found in follicular fluid. For this reason, the effect of follicular fluid on the ovum maturation was investigated by applying Krebs-Ringer bicarbonate solution (SECM), which was main1y composed of the salts, pyruvate and lactate. When the oocytes were cultured in SECM without the addition of follicular fluid, only 7-14% of them resumed meiotic division within 30 hours. However, when follicular fluid was added, the proportion of oocytes undergoing maturation was sharply increased to about 70%. Among the groups cultured in media containing different concentrations of follicular fluid, the proportion of the oocytes in meiosis remained constant, In pure follicular fluid, 87-89% of the oocytes showed enhancement of meiotic division. The presence of the follicular fluid contributed to a decrease in the production of degenerative oocytes. As a consequence it has been noted that addition of follicular fluid to the culture medium provides a more beneficial environment for cow oocytes. Meiotic division is initiated and production of degenerative oocytes is inhibited.
Animal ; Cattle ; Cells, Cultured ; Culture Media ; Female ; Meiosis ; Oocytes/physiology* ; Ovarian Follicle/physiology* ; Ovum/physiology*

No abstract available.
Arthroplasty, Replacement, Hip*

Purpose: Inhalant allergens are known as a major factor for respiratory allergic diseases. There are many differences in sensitization rates of inhalant allergens, depending on the environment and demographic factors. This study aimed to compare the cross-sectional differences in sensitivity patterns to inhalant allergen between children, adolescents, and adults. Methods: We analyzed the results of 449 patients with asthma or allergic rhinitis who underwent the inhalant allergen skin prick test at our university hospital in 2016. The subjects were classified 5 groups according to age: children ( ≤ 12 years), adolescents (13–17 years), young adults (18–30 years), middle adults (31–64 years), and elderly group ( ≥ 65 years). Positive responses skin prick test for allergens were defined as allergen-to-histamine wheal ratio ≥ 1. Results: The sensitization rate (SR) to house dust mites (HDM) was 52.1% on average, showing the highest SR in all groups, especially in children (64.2%). Children and adolescents showed high SRs to cockroach along with tree pollen, animal fur, and adults showed high SR to weed pollen along with them. Among the tree pollen, the SRs to oak, alder, birch, and beech were high in all groups; in children, the SR to plain and willow tended to be high, and in adults the SR to hazel was high. SRs to Timothy pollen (9.9%) and Alternaria (8.6%) tended to be higher in children than in the other groups. Conclusion Although HDM is still the major allergen in children and adults with respiratory allergy, our study suggests various differences in the sensitization pattern to inhalant allergens according to age even in the same area. Further studies are needed to explain these differences in sensitization patterns.

Background/Aims: Although the number of domestic adverse drug reactions (ADRs) reported in Korea is rapidly increasing, the analysis of ADRs in cancer patients remains limited. We sought to investigate the clinical features of ADRs in cancer patients. Methods: ADR data were collected from a spontaneous reporting system at single university hospital, between July 2010 and June 2015. ADR cases assessed to be “unlikely” or “unclassifiable” as per the criteria of the World Health Organization-Uppsala Monitoring Center were excluded. Additional medical information was retrospectively collected from chart reviews, and clinical features of ADRs were analyzed. Results: In total, 1,455 cases were reported. Of these, 822 ADRs (52.1%) were observed in cancer patients. The mean age of cancer patients was 60.8 years (range, 17–90 years), and 45.9% were male. The most prevalent clinical features were gastrointestinal abnormalities (32.6%), such as nausea and vomiting, followed by skin (28.5%) and neurologic manifestations (26.0%). Fifty-one (6.2%) and 296 cases (36.0%) were classified as severe and moderate, respectively. The most common causative agents were parenteral nutrition (PN) supplements (40.4%), followed by antibiotics (17.8%), analgesics (16.7%), iodinated contrast media (ICM, 10.6%), and vitamins (3.9%). Antineoplastic agents were responsible for 2.9% of cases. PN supplements were commonly associated with severe reactions. Conclusion Although it is well known that antibiotics, ICM, and analgesics induce ADRs, PN supplements, vitamins, and antineoplastic agents should also be considered as common causes of ADRs in cancer patients. Further investigation and monitoring to determine the causality associated with these agents is required.

Purpose: Contact dermatitis (CD) is a common skin disease caused by various allergens that can be identified by patch test (PT). Despite the analysis of PT outcomes in various regions of Korea, no specific investigation has targeted the Busan area. We aimed to analyze PT results using Chemotechnique in patients suspected of CD in Busan. Methods: We reviewed medical records of 273 patients who underwent PT between 2019 and 2020 at two university hospitals in Busan. PT results were interpreted according to the International Contact Dermatitis Research Group criteria. Results: Among the patients, 86.4% exhibited positive reactions to at least one allergen. Those with positive outcomes displayed a higher comorbidity rate of chronic urticaria but a lower rate of atopic dermatitis. Moreover, they reported higher positivity rates to questions about sexual life and treatment on the Dermatology Life Quality Index questionnaire. Major allergens in Busan were cobalt chloride (60.1%), nickel sulfate (52.0%), and potassium dichromate (50.9%), followed by thiomersal, balsam of Peru, and fragrance mix (17.2%, 15.4%, and 13.9%, respectively). Captan, budesonide, and colophony were more prevalent allergens in males. While the positive rate for thiomersal were higher in the younger age group, balsam of Peru allergen was higher in the older age group. Conclusion This study represents the first PT analysis conducted in Busan, revealing metal-related allergen as the most common cause of CD, with variations observed across sex and age. Further research is needed to validate these findings and elucidate the sources and pathways of allergen exposure in Busan.

Purpose: Contact dermatitis (CD) is a common skin disease caused by various allergens that can be identified by patch test (PT). Despite the analysis of PT outcomes in various regions of Korea, no specific investigation has targeted the Busan area. We aimed to analyze PT results using Chemotechnique in patients suspected of CD in Busan. Methods: We reviewed medical records of 273 patients who underwent PT between 2019 and 2020 at two university hospitals in Busan. PT results were interpreted according to the International Contact Dermatitis Research Group criteria. Results: Among the patients, 86.4% exhibited positive reactions to at least one allergen. Those with positive outcomes displayed a higher comorbidity rate of chronic urticaria but a lower rate of atopic dermatitis. Moreover, they reported higher positivity rates to questions about sexual life and treatment on the Dermatology Life Quality Index questionnaire. Major allergens in Busan were cobalt chloride (60.1%), nickel sulfate (52.0%), and potassium dichromate (50.9%), followed by thiomersal, balsam of Peru, and fragrance mix (17.2%, 15.4%, and 13.9%, respectively). Captan, budesonide, and colophony were more prevalent allergens in males. While the positive rate for thiomersal were higher in the younger age group, balsam of Peru allergen was higher in the older age group. Conclusion This study represents the first PT analysis conducted in Busan, revealing metal-related allergen as the most common cause of CD, with variations observed across sex and age. Further research is needed to validate these findings and elucidate the sources and pathways of allergen exposure in Busan.

Purpose: Contact dermatitis (CD) is a common skin disease caused by various allergens that can be identified by patch test (PT). Despite the analysis of PT outcomes in various regions of Korea, no specific investigation has targeted the Busan area. We aimed to analyze PT results using Chemotechnique in patients suspected of CD in Busan. Methods: We reviewed medical records of 273 patients who underwent PT between 2019 and 2020 at two university hospitals in Busan. PT results were interpreted according to the International Contact Dermatitis Research Group criteria. Results: Among the patients, 86.4% exhibited positive reactions to at least one allergen. Those with positive outcomes displayed a higher comorbidity rate of chronic urticaria but a lower rate of atopic dermatitis. Moreover, they reported higher positivity rates to questions about sexual life and treatment on the Dermatology Life Quality Index questionnaire. Major allergens in Busan were cobalt chloride (60.1%), nickel sulfate (52.0%), and potassium dichromate (50.9%), followed by thiomersal, balsam of Peru, and fragrance mix (17.2%, 15.4%, and 13.9%, respectively). Captan, budesonide, and colophony were more prevalent allergens in males. While the positive rate for thiomersal were higher in the younger age group, balsam of Peru allergen was higher in the older age group. Conclusion This study represents the first PT analysis conducted in Busan, revealing metal-related allergen as the most common cause of CD, with variations observed across sex and age. Further research is needed to validate these findings and elucidate the sources and pathways of allergen exposure in Busan.