No abstract available.
Animals ; Metaphase* ; Mice* ; Oocytes*

A study of normal value of fetal hemoglobin concentration at each age in 1213 cases (852 patients, 361 normal children) who visited Chonnam university hospital from June 1977 to November 1978 was performed by alkali denaturation method, and following results were obtained. 1) The mean value of Hgb F at each age in normal children group was 65.5+/-1.8% in newborn infants during 24 hours, 40.5+/-1.6% in 1 month, 24.3+/-1.2% in 2 months, 15.3+/-1.4% in 3 months, 4.5+/-1.2% in 1 year 1.3+/-0.5% in 5 years, 0.9+/-0.7% in 10 years, 0.5+/-0.3% in 15 years. 2) The mean value of Hgb F at each age in patients group was 68.6+/-2.5% in newborn infants during 24 hours, 42.5+/-1.7% in 1 month, 22.9+/-1.1% in 2 months, 15.2+/-0.9% in 3 months, 5.5+/-1.0% in 1 year, 1.4+/-0.4% in 5 years, 0.9+/-0.6% in 10 years, 0.6+/-0.2% in 15 years. 3) The mean value of Hgb F at each age in both group was 67.5+/-2.0% in newborn infants during 24 hours, 41.8+/-2.1% in 1 month, 23.4+/-1.9% in 2 months, 15.2+/-1.0% in 3 months, 5.1+/-1.1% in 1 year, 1.4+/-0.8% in 5 years, 0.9+/-0.2% in 10 years, 0.6+/-0.2% in 15 years. 4) No significant correlation was found in the concentration of Hgb F at each age between normal children group and patients group, and either in the concentration of Hgb F at each sex of two groups.
Alkalies ; Child* ; Fetal Hemoglobin* ; Humans ; Infant, Newborn ; Jeollanam-do ; Reference Values*

A study on prevalence of hepatitis B surface antigen(HBsAg) in 1,292 grade-school children(548 of rural area, 744 of urban area) by Counterimmunoelectrophoretic method: various liver fuction tests and liver biopsy were performed, and the results obtained are as follows: 1) Fifty four of 1,292 children who were selected randomly were positive for HBsAg(4.2%) and incidence of HBsAg was higher in rural area(4.6%) than in urban area(3.9%). 2) The incidence of HBsAg was higher in male children(4.5%) than female Children(3.7%). 3) Age distribution revealed highest incidence at 10(5.9%), years old lowest incidence at 9(2.9%), but any significant interrelationship wasn't found between ages. 4) The order of liver function tests which showed abnormal values by numver are as follows: GGT(26.2%), SGOT(23.6%), Total protein(7.1%), SGPT(4.8%), TTT(4.8%), BSP retention test(2.4%), PT(0%). The values of GGT and SGOT were thought to be most useful in HBsAg positive children. 5) All tests showed normal values in 22 children(52.4%), one test and more than 2 tests showed abnormal values each in 18 children(42.8%) and in 2 children(4.8%). 6) On liver biopsy performed in nine HBsAg positive children, one showed normal liver tissue, two showed mild hepatocellular degenerative change, five showed chronic persistent hepatitis and showed chronic active hepatitis. On orcein staining, three showed intracytoplasmic inclusion bodies thought to be HBsAg.
Age Distribution ; Aspartate Aminotransferases ; Biopsy ; Child* ; Female ; Hepatitis B ; Hepatitis B Surface Antigens* ; Hepatitis, Chronic ; Humans ; Incidence ; Inclusion Bodies ; Liver ; Liver Function Tests ; Male ; Prevalence ; Reference Values

PURPOSE: To evaluate potential correlation between the extent and site of avascular necrosis (AVN), as determined by preoperative magnetic resonance (MR) imaging, and the development of femoral head collapse. MATERIALS AND METHODS: Using clinical, radiographic and MR imaging criteria, twenty hips in 15 patients were selected for core decompression. Preoperative MR results were classified into three categories: group A, less than 15% involvement of the weight-bearing portion of the femoral head; group B, 15%-30% involvement; group C, more than 30% involvement, according to ARCO staging. We also established three groups according to site of involvement of the femoral head, namely medial, middle and lateral. RESULTS: Of 20 cases, three were stage Ia; two, Ib; four, Ic; three, IIa; two, IIb; and 6, IIc. Ten cases of Ia, Ib, IIa or IIb showed no femoral head collapse during follow-up of at least 24 months, while ten cases of Ic or IIc showed femoral head collapse. CONCLUSION: The prognosis of core decompression in patients with early AVN is related to the area of lesion in the femoral head.
Decompression* ; Follow-Up Studies ; Head* ; Hip ; Humans ; Magnetic Resonance Imaging* ; Necrosis* ; Prognosis ; Weight-Bearing

BACKGROUND: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that this is a refractory disease which may cause a deleterious effect on patients' quality of life (QOL). OBJECTIVE: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the changes of QOL after treatment. METHODS: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after systemic antifungal treatment. Responses to the questionnaire were scored by f-point scale (0~4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptom and functional impact, patients' views concerning treatment, and relationship with doctor. RESULTS: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients' QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS: from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients' view concerning treatment(AS: from 1.34 to 1.02) 4. The degree of patients' satisfaction at the therapeutic effect was very high - 62.4% (immediately after. treatment) and 65.8% (9 months after initiation of treatment) of patients answered excellent or good. CONCLUSION: This study confirms that toenail onychomycosis has significant Impact on the overall QOL of patients. Also the effect of antifungal therapy on patients' QOL were satisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis.
Female ; Humans ; Korea* ; Male ; Nails* ; Onychomycosis* ; Quality of Life* ; Social Change ; Surveys and Questionnaires