The Marfan syndrome, a rare disease causing a marked decrease in life expectancy by involving the skeletal, ocular, and cardiovascular systems, is known as a connective tissue disorder that is inherited autosomal dominant. The cardiovascular complications directly related to the cause of death are associated with more than 90% of the Marfan syndrome. Aortic aneurysm with rupture could occur because of dilatation of aorta due to defect of media. Aortic and mitral insufficiency, mitral valve prolapse, bacterial endocarditis, arrhythmia, and aneurysm of interatrial septum are also frequently observed. A few literatures were reported domestically pertaining to the Marfan syndrome thus far, and there are increased discoveries of cardiovascular complications of the syndrome with the application of echocardiogram. However, the Marfan syndrome with LA myxoma has never been reported both domestically and internationally(INDEX MEDICUS, 1966-1989). Therefore we hereby report a case of the Marfan syndrome with LA myxoma from the observation of a patient who was admitted to Eulji General Hospital at Taejeon i August of 1989.
Aneurysm ; Aorta ; Aortic Aneurysm ; Arrhythmias, Cardiac ; Cardiovascular System ; Cause of Death ; Connective Tissue ; Daejeon ; Dilatation ; Echocardiography* ; Endocarditis, Bacterial ; Hospitals, General ; Humans ; Life Expectancy ; Marfan Syndrome* ; Mitral Valve Insufficiency ; Mitral Valve Prolapse ; Myxoma* ; Rare Diseases ; Rupture

Even though phototherapy is an effective means of treating hyperbilirubinemia, adequate binocular shields are essential to prevent light hazard of retina during phototherapy. The phototherapy to young albino rabbits was performed under various conditions; exposured for 12, 24, and 48 hours, continuity or intermittence of irradiation, and use of shields. Although there was no definite pathologic change in indirect ophthalmoscopic examination, severe damage was seen at electron microscopic level. In all experimental groups, swelling and edema of photoreceptor were seen. at right after phototherapy. Futhermore, more severe damage was seen in case of intermittent irradiated group and prolong exposed group. In mydriatic eyes, severity of damage was similiar to non mydi iatic eyes, but area of retinal damage was more extensive than non-mydriatic eves.. In control group which was protected by binocular shields during phototherapy, no significant abnormality was found.
Dermatitis, Phototoxic* ; Edema ; Hyperbilirubinemia ; Phototherapy ; Rabbits ; Retina ; Retinaldehyde* ; Telescopes

No abstract available.
Bilirubin* ; Humans ; Infant, Newborn*

PURPOSE:Decreased bone mineral density(BMD) has been reported in girls with Turner syndrome. Estrogen therapy is recommanded to improve sexual infantilism and decreased BMD. Short stature is also characteristic finding in patients with Turner syndrome. Treatment modality for short stature has included estrogen, anabolic steroids and growth hormone(GH). Recently GH therapy in GH deficient children could increase BMD in addition to improve short stature. We observed the treatment effects on bone mineral density in patients with Turner syndrome. METHODS: Bone Mineral Density in second to fourth lumbar spine area were measured by dual energy X-ray absorptiometry in 56 girls with Turner syndrome, before and after growth hormone and/or estrogen. All Turner girl was confirmed by clinical and chromosomal examination. RESULTS: 1) There was no significant difference in BMD according to karyotype. 2) The mean BMD of untreated Turner syndrome was 0.752+/-0.122g/cm2. 3) The mean BMD before and after GH treatment were 0.620+/-0.028g/cm2, 0.793+/-0.093g/cm2 respectively. The mean BMD before and after estrogen treatment were 0.761+/-0.125g/cm2, 0.918+/-0.141g/cm2 respectively. In combined group, the BMD were 0.752+/-0.087g/cm2 and 0.939+/-0.134g/cm2. Growth hormone was also effective to improve BMD as well as estrogen. But the changes of BMD were more significant in estrogen and combined group(p<0.05). 4) A significant positive correlation was found between age and BMD(p<0.05). CONCLUSIONS:Estrogen therapy can accelerate epiphysial maturation and compromise final height. Growth hormone therapy in Turner girls was effective for improvement bone mineral density as well as growth improvement. But growth hormone and estrogen combined therapy or Estrogen therapy is more effective to improve bone mineral density in Turner syndrome. Estrogen replacement can be delayed for a while on growth hormone treatment and the appropriated time of estrogen therapy should be elucidated.
Absorptiometry, Photon ; Bone Density* ; Child ; Estrogen Replacement Therapy ; Estrogens ; Female ; Growth Hormone ; Humans ; Karyotype ; Sexual Infantilism ; Spine ; Steroids ; Turner Syndrome*

Among 157 cases operated upon, under the diagnosis of herniated intervertebral disc, we experienced 34 cases of discrepancies between myelographic and operative findings. We analysed these cases in the respect of patterns, causes and clinical significance of these discrepancies and the results were as follow; 1. Thirty four cases (21.7%) among 157 cases operated upon showed discrepancies between myelographic and operative findings. 2. These 34 cases consisted of 17 cases of level discrepancies, 9 cases of false positive and 8 cases of false negative. 3. The main cases of level discrepancies was indentation due to bony spur with/without adhesion. 4. The main cause of false positive was degenerative changes of the spine. In the detection of this false positive, plain X-ray of lumbosacral spine give important clue. In false positive, explorative paitial laminectomy and removal of bony spur or adhesiolysis was indicated because the effect of the spur or adhesion was same as that of herniated disc. 5. The causes of false negative were giant canal, congenitally narrow cul de sac, high cul de sac and far laterally seated disc herniation. In false negative, plain X-ray of lumbosacral spine afforded little diagnostic aid. In case of being compatible to disc herniation at a certain level through clinical signs, normal myelographic finding has less meanings and exploration is to be performed according to the clinical signs.
Diagnosis ; Intervertebral Disc ; Intervertebral Disc Displacement ; Laminectomy ; Spine

PURPOSE: GH-releasing peptide(GHRP-6) was shown to possess strong GH-releasing activity both in vitro and in vivo. Chemically,GHRP-6 has no primary sequence homology with GHRH. The GH releasing activity of GHRP-6 has been demonstrated in several animal species including humans. GHRPs could have a considerable physiological and clinical useful for treatment of GH deficient and/or non GH deficient short children in the near future. The aim of this study was to evaluate the GH-releasing activity of GHRP-6 in anterior pituitary cell culture and compared to that of GHRH . METHODS: Spraque-Dawley rats were decapitated and pituitary glands were collected in ice-cold PBS. The anterior pituitaries were minced into small fragments and dissociated by enzymatic digestion. These pituitary cells were suspended in Dulbecco' modified Eagle' medium(DMEM) with fetal calf serum at a concentration of 106cells/mL and then plated onto multiwelled dishes at a density of 1.5*05 cells per 6 well plate. GHRP-6 treated group(10-8, 10-7, 10-6 M), GHRH treated group(10-8, 10-7, 10-6 M) and combined GHRP-6 and GHRH treated group were classified. After replacement of each GHRP and/or GHRH+GHRP, the released GH were measured with RIA in 10 min, 20 min, and 30 min. RESULTS: 1) GHRH(10-8) treatment increased GH release by 15.8+/-3.9ng/mL in 0 min., 69.8+/-4.3ng/mL in 10 min. 78.3+/-5.0ng/mL in 20 min. and 67.8+/-7.2ng/mL in 30 min. In case of GHRP-6(10-8M) treatment increased GH release by 11.0+/-1.4 in 0 min., 90.3+/-12.2 in 10 min., 78.3+/-4.5ng/mL in 20 min. and 78.0+/-4.8ng/mL in 30 min. The released GH levels were markedly increased in 10 min. after GHRP-6 and were not singificantly different from that of GHRH. 2)GHRP+GHRH(10-7M+10-8M) treatment increase GH release by 8.8+/-1.5ng/mL in 0 min., 37.8+/-9.3ng/mL in 10 min., 41.3+/-8.1ng/mL in 20 min. and 40.0+/-7.9ng/mL in 30 min. The released GH levels after GHRP+GHRH treatment was not markedly increased statistically compared to GHRH only. CONCLUSION: GHRP-6 could release GH in rat anterior pituitary cell culture and the released GH amounts were not significantly different from that of GHRH. There was no synergistic additive effect in GHRP+GHRH in rat pituitary cell culture.
Animals ; Cell Culture Techniques* ; Child ; Digestion ; Growth Hormone* ; Humans ; Pituitary Gland ; Rats* ; Sequence Homology

As the development of the percutaneous renal surgery, Ureteropelvic junction obstruction can be treated with endourologic technique instead of open surgery. Precutaneous endopyelotomy has been used mainly for the treatment of secondary ureteropelvic junction obstruction. But it was also successful for treatment of primary ureteropelvic junction obstruction. Recently, we performed endopyelotomy for 3 cases of ureteropelvic junction obstruction a 39 years-old male who had renal pelvic stones combined with ureteropelvic junction, a 32 years-old male with ureteropelvic junction obstruction and a 23 years-old male who had horseshoe kidney combined with ureteropelvic junction obstruction and good results were obtained.
Adult ; Humans ; Kidney ; Male ; Young Adult

We observed 62 patients who were admitted to the Pediatric Department of Severance Hospital for the treatment of pleurisy with effusion during the period of 11 years from Apr. 1965 to May 1975. The following results was obtained. 1) Age and sex incidence : 72.6% were between the age of 3 to 12 years. The sex ratio of male to female was 1.7:1. 2) Seasonal incidence : Effusion occured most commonly in the spring(33.9%) least often in the winter(17.8%). 3) Symptoms on admission in order were fever,(77.4%) cough,(61.3%) dyspnea,(40.3%) Chest pain, (27.4%) etc. 4) There was a contact history with tuberculous family in 17 cases(27.3%). P.P.D skin test was positive in 43 cases(69%). 5) The site of effusion was 60% on the right and 40% on the left. 6) In all cases, antitubeculous drugs were used. Among 54 cases treated with prednisolone, pleural fluid was disappeared completly in 21 cases within 2 weeks.
Chest Pain ; Female ; Humans ; Incidence ; Male ; Pleurisy* ; Prednisolone ; Seasons ; Sex Ratio ; Skin Tests

No abstract available.
Blood Pressure* ; Cadmium* ; Plasma* ; Renin*

No abstract available.
Byssinosis* ; Carbon* ; Daegu* ; Korea* ; Textiles*