Primary role of ultrasound in patients with thyroid nodule is to determine the multiplicity and detect occult carcinoma. We analyzed US findings of 53 thyroid carcinomas with multiple nodular lesions from january 1988 to december 1991. The results were as follows: 1. 109 malignant nodules in 53 cases and 24 benign in 23 were comfirmed. 2. The nature of the masses were solid in 72 malignant nodules (74.2%), and complex in 25 (25.8%) of which 19 were predominantly solid. 3. The echo pattern of the solid and solid predominant masses were hypoechoic in 78 malignant nodules (80.4%), hyperechoic in 10 (10.3%), and isoechoic in 3 (9.3%) 4. Internal punctate calcifications within the masses were observed in 31 malignant nodules (31.9%). 5. Halo sign was present in 16 malignant nodules(16.5%). 6. The preoperative sonographic diagnosis of thyroid carcinoma was made in 39.4% of 53 cases with multiple nodules on US. In conclusion, the number, and halo formation of nodules were insignificant to differentiate the benign nodule from the malignant. The heterogeneous hypoechoic nodules with size greater than 4cm, multiple stippled calcifications, displacement of the trachea or other surrounding structures of combined lymph node enlargements seem to indicate the possibility of malignancy.
Diagnosis ; Goiter* ; Humans ; Lymph Nodes ; Thyroid Gland* ; Thyroid Neoplasms* ; Thyroid Nodule ; Trachea ; Ultrasonography

We report the results of field operation of TELEACE system between Kyung-Pook National University Hospital and Ul-Jin Goon Health Care Medical Center from December, 1990 to September, 1991, which had been operated as a kind of Integrated Services Digital Nework projects by KOREA TELECOMMUNICATION Inc. Ul-Jin Goon Health Care Medical Center transmitted 414 plain radiographs to our hospital in speed of 9600BPS. Each image was composed of 1024X1024 pixelsX8 bits/pixel. In our hospital, the image files were displayed on high resolution monitor (1280×1024 pixets). Text files of image interpretations were transmitted to the health care medical center. The two radiologists who had interpreted the transmitted images, went to the health care medical center and read radiographic film with blind test method. We obtained the following results: false negative rate of 6.3%, false postitve rate of 2.4%, mean sensitivity of 81.4%, mean specificity of 96.3%, and mean accuracy of 91.3%. In predictive value of 0.05, there was no significant difference between results of these two types of radiographs. In conclusion, TELEACE system was valuable to the clinicians isolated from services of radiologists.
Delivery of Health Care ; Korea ; Methods ; Sensitivity and Specificity ; Telecommunications ; X-Ray Film

No abstract available.
Child* ; Humans ; Immunoglobulin E* ; Nephrosis, Lipoid*

PURPOSE: Long-term administration of anticonvulsants in children with epilepsy may cause short stature, hypocalcemia and low bone mineral density. This study was performed for the early detection of abnormal bone metabolism in children with epilepsy on taking anticonvulsants. METHODS: Thirty children aged 5 to 16 years who were diagnosed with epilepsy were enrolled in this study. All had taken anticonvulsants for more than one year. Bone mineral density of lumbar vertebra was measured by dual-energy X-ray absorptiometry. Serum calcium, phosphorous, alkaline phosphatase, 25-hydroxycholecalciferol[25(OH)D3], parathyroid hormone, and urine deoxypyridinoline were measured as biochemical bone markers. Bone age and body mass index were also calculated. RESULTS: Bone minreal density, body mass index, bone age, and height were significantly decreased in two female patients who had taken two antiepileptic drugs for more than four years and they also had chronic diseases such as cerebral palsy with microcephaly, encephalomalacia, and microcephaly with atrial septal defect. Bone mineral density had significant positive correlations with body mass index(P<0.01) and bone age(P<0.01). CONCLUSION: This study showed chronic medication of anticonvulsants in children may cause low bone mineral density and short stature. Bone age and body mass index could be the important surrogate markers to find the population at risk. More studies, including a large study population and long term cohort study, will be required.
Absorptiometry, Photon ; Alkaline Phosphatase ; Anticonvulsants* ; Biomarkers ; Body Mass Index ; Bone Density* ; Calcium ; Cerebral Palsy ; Child* ; Chronic Disease ; Cohort Studies ; Encephalomalacia ; Epilepsy* ; Female ; Heart Septal Defects, Atrial ; Humans ; Hypocalcemia ; Metabolism ; Microcephaly ; Parathyroid Hormone ; Population Characteristics ; Spine

No abstract available.
Atrial Fibrillation* ; Heart* ; Thoracic Surgery*

Telomerase is an enzyme that maintains telomeres and prevents telomere shortening, and may be linked with cellular proliferation or the aging process. The purpose was to examine telomerase activity in human chorionic villi from early and term normal pregnancies, and to analyze the correlation of telomerase activity (TA) with MIB-1 & bcl-2. A total of 37 placentae were obtained from 16 early and 21 term pregnancies. TA was assayed by telomeric repeat amplification protocol, and immunohistochemical staining was performed for MIB-1 & bcl-2 expression. TA & MIB-1 expression were strong in early placenta, but bcl-2 was highly expressed in term placentae. Thirteen (81.25%) of 16 early placentae showed TA, but only 2 (9.52%) of 21 term placentae expressed TA (p<0.01). MIB-1 was observed in nuclei of cytotrophoblast, and the expression rate was 16.09% in early placentae and 2.87% in term placentae (p<0.01). bcl-2 was observed only in the cytoplasm of syncytiotrophoblast. Term placenta demonstrated stronger expression of bcl-2 compared to early placentae (p<0.05). These findings suggest that TA, MIB-1 & bcl-2 expression are critically regulated over the course of gestation: cytotrophoblast, main cells of early chorionic villi, may be a common source of telomerase and proliferative activity. The TA showed good correlation with cellular proliferative activity. Syncytiotrophoblast, may be a main source of bcl-2 expression which is stronger in the term placentae.
Aging ; Cell Proliferation ; Chorion* ; Chorionic Villi* ; Cytoplasm ; Humans* ; Placenta ; Pregnancy* ; Telomerase* ; Telomere ; Telomere Shortening ; Trophoblasts

No abstract available.
Sertoli-Leydig Cell Tumor*

PURPOSE: To investigate the postoperative patterns of weight-gain in early infants with ventricular septal defects (VSDs), we analyze 48 patients who received primary surgical closure of the symptomatic VSDs during 6 months of age in the period of 1993 through 1995. METHODS: Forty-sixt infants met criteria for inclusion in the study. The mean follow up period was 14 months (3 to 36 months). Weight percentile was extrapolarated from data of the Korean boys and girls measured in 1985. The data was compared by one-group paired student t-test. RESULTS: The overall mortality rate of this study was 4% (2/48). No surviving patients required a second ventricular septal defect operation, and the majority no longer received anticongestive therapies. The mean percentile of the preoperative weight was 3.53. In postoperative follow up period, they grew steadily. But, the mean weight percentile was only 5.46 in age under 6 months. Mean 12 percentile was achieved in age of 6 to 8 months, hence 25.4 percentile in 9 to 12 months, 33.5 percentile over 12 months, 64.8 percentile over 24 months of age. The weighing pattern of the patients with smaller defect was similar in 24 patients (52%) with large VSD, which size were same or larger than diameter of the aortic root. CONCLUSIONS: This study indicated that the patients under 6 months who have undergone primary surgical closure of the symptomatic large ventricular septal defects could gain the weight normally in postoperative period. Although the weight-gain was not sufficient when the age was under 12 months, It became normal pattern of weighing in age over 12 months.
Female ; Follow-Up Studies ; Heart Septal Defects, Ventricular* ; Humans ; Infant* ; Mortality ; Postoperative Period

PURPOSE: To investigate the postoperative patterns of weight-gain in early infants with ventricular septal defects (VSDs), we analyze 48 patients who received primary surgical closure of the symptomatic VSDs during 6 months of age in the period of 1993 through 1995. METHODS: Forty-sixt infants met criteria for inclusion in the study. The mean follow up period was 14 months (3 to 36 months). Weight percentile was extrapolarated from data of the Korean boys and girls measured in 1985. The data was compared by one-group paired student t-test. RESULTS: The overall mortality rate of this study was 4% (2/48). No surviving patients required a second ventricular septal defect operation, and the majority no longer received anticongestive therapies. The mean percentile of the preoperative weight was 3.53. In postoperative follow up period, they grew steadily. But, the mean weight percentile was only 5.46 in age under 6 months. Mean 12 percentile was achieved in age of 6 to 8 months, hence 25.4 percentile in 9 to 12 months, 33.5 percentile over 12 months, 64.8 percentile over 24 months of age. The weighing pattern of the patients with smaller defect was similar in 24 patients (52%) with large VSD, which size were same or larger than diameter of the aortic root. CONCLUSIONS: This study indicated that the patients under 6 months who have undergone primary surgical closure of the symptomatic large ventricular septal defects could gain the weight normally in postoperative period. Although the weight-gain was not sufficient when the age was under 12 months, It became normal pattern of weighing in age over 12 months.
Female ; Follow-Up Studies ; Heart Septal Defects, Ventricular* ; Humans ; Infant* ; Mortality ; Postoperative Period

No abstract available.
Drug Therapy* ; Humans ; Neutropenia*