Venous hemangioma is a vascular tumor that has been reported by such diverse names as; "cirsoid aneurysm", "arteriovenous hemangioma", "acral arteriovenous tumor" according to the author's opinions of its origin and histopathologic classification. It is benign and rarely biopsied, and it is also rarely reported in dermatology literature. We present two cases of venous hemangioma. The first case was a 64-year-old man who was presented with an elliptical dark-red plaque with overlying several grouped papules on the left periorbital area which had been present for 7 years. The second case was a 56-year-old man who was presented with a single red papule on the right postauricular area which had been present for 4 months. Histopathologically, there were a well-circumscribed proliferation of thick-walled muscle-containing blood vessels in the dermis. Intermingled with the thick-walled blood vessels, there were also thin-walled dilated blood vessels. In both cases, the thick-walled blood vessels resembled arteries, but they lacked elastic fibers on the Verhoeff van Gieson stain.
Arteries ; Blood Vessels ; Classification ; Dermatology ; Dermis ; Elastic Tissue ; Hemangioma* ; Humans ; Middle Aged

Cutaneous smooth muscle hamartomas are benign proliferations of smooth muscle bundles within the dermis. They can be congenital or acquired, and most cases are congenital. Congenital smooth muscle hamartomas (CSMHs) usually manifest at birth as well-circumscribed, frequently hypertrichotic, hyperpigmented or skin-colored patches or plaques on trunk or extremities. We report a case of CSMH in a 10 year-old girl, who showed a localized skin-colored patch showing prominent follicular papules on the lateral aspect of her right upper arm, which were found at birth. There was no hypertrichosis and the pseudo-Darier sign was negative. This patchy follicular variant is the less common clinical type of the disease.
Arm ; Dermis ; Extremities ; Female ; Hamartoma* ; Humans ; Hypertrichosis ; Muscle, Smooth* ; Parturition

This experiment was performed the effect of the glycoconjugates of the skin in the Sprague-Dawley male rats exposed to SO2 for 1, 3 and 6 hours with various concentrations (10, 25, 50, 100 and 200 ppm). To investigate the change of glycoconjugates of skin, seven biotinylated lectins (DBA, SBA, PNA, BSL-1, sWGA, UEA-1, Con A) were applied with ABC method. The epidermis of experiment rats was more or less different according to the concentration of SO2, comparing control group, and beta-N-acetyl-D-galactosamine, alpha-L-fucose, alpha-D-mannose and alpha-D-glucose of the epidermis tend to be increased according to exposed SO2 time, but alpha-D-galactose was tend to be decreased. Galactose-beta-1, 3-Nacetyl- D-galactosamine was tend to more or less increase in horny layer of the epidermis, but decrease in granular and spinous layers. As contrasted control group, beta-N-acetyl-D-glucosamine in the dermis of experiment rats was decreased, but alpha- D-mannose and alpha-D-glucose were increased. In the hair follicle of the experiment rats, beta-N-acetyl-D-galactosamine and galactose-beta-1, 3-N-acetyl-Dgalactosamine tend to be decreased according to exposed SO2 time though more or less differ from the portions of the hair follicle, and beta-N-acetyl-D-glucosamine and alpha-L-fucose were found noticeably to increase comaring control group. According to exposed SO2 time, the decrease of alpha-D-galactose tend to be little more pronounced in the outer root sheath of the upper portion of hair follicle. In contrast, the same sheath of the upper portion in above follicle was increased relatively. alpha-D-mannose and alpha-D-glucose were increased in the root sheath of hair follicle and hair cortex, but decreased in the hair medulla. In the experiment rats, the beta-N-acetyl-D-galactosamine tend to be decreased gradually according to exposed SO2 time, but the decrease of galactose-beta-1, 3-N-acetyl-D-galactosamine were showed significantly as contrasted control group. beta-N-acetyl-D-glucosamine, alpha-D-mannose and alpha-D-glucose were increased gradually according to exposed SO2 time, but alpha-L-fucose was increased remarkably. The effect on lectin binding pattern of the glycoconjugates in the rat skin according to the concentrations and exposed time of SO2 was noted that the alternations of lectin binding pattern tend to be a little more pronounced in low concentration of exposed SO2 for a long time than in high concentration of exposed SO2 for a short time. The alternations of lectin binding pattern were appeared almost similar in concentrations of 50 ppm SO2 and above.
Animals ; Dermis ; Epidermis ; Glycoconjugates* ; Hair ; Hair Follicle ; Humans ; Lectins ; Male ; Mannose ; Rats* ; Rats, Sprague-Dawley ; Skin* ; Sulfur Dioxide* ; Sulfur*

Although a number of remedies like corticosteroids, retinoids, griseofulvin, PUVA, cyclosporine, antibiotics, dapsone, cyclophosphamide, surgery, methotrexate, radiation therapy, antimalarial drugs, psychotharapy and psychiatric medications have been used to treat lichen planus, there were no specific methods until now. We report herein an interesting case of lichen planus in which complete healing was achieved by griseofulvin administration. The patient was a 54-year-old male who for 3 months had variouly sized and shaped, flat-topped, scaly, violaceous papules and plaques on the whole of his body. We confirmed the patients disease as lichen planus by a histopathologic examination of a skin biopsy specimen and gave him 500mg ultramicronized griseofulvin daily in divided dosages. After 12 weeks of the medication nearly all of the skin lesions were regressed, and by 14 weeks all skin lesions had disappeared leaving hyperpigmentation. Up to now, l9 months after discontinuation of the medication, no recurrence of the disease has been noted.
Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Antimalarials ; Biopsy ; Cyclophosphamide ; Cyclosporine ; Dapsone ; Griseofulvin* ; Humans ; Hyperpigmentation ; Lichen Planus* ; Lichens* ; Male ; Methotrexate ; Middle Aged ; Recurrence ; Retinoids ; Skin

No abstract available.
Blood Platelets* ; Disseminated Intravascular Coagulation* ; Platelet Activation*

No abstract available.
Humans ; Male ; Nursing* ; Urinary Incontinence*

No abstract available.
Humans ; Infant* ; Zinc*

No abstract available.

No abstract available.
Angiotensins* ; Cough* ; Peptidyl-Dipeptidase A* ; Reflex*

Drusen are small, yellowish deposits that form under the retinal pigment epithe lium with senescence or under certain pathological conditions. The present study examined these structures under the scanning electron microscope. Tissue came from the eyes of four donors, who were 22, 56, 60 and 61 years of age and who demonstrated widespread drusen of the posterior fundus. which was noted on postmortem examination. Specimens were prepared by detaching the retinal pig ment epithelium from Bruch's membrane and freeze fracturing the tissue. Drusen appeared as follows: 1. Distinct spherical masse, 10 X 9 um and 9 X 7 um in size, were situated between basement membrane of the retinal pigment epithelium and Bruch's membrane. The surface of the spherical masses were smooth. 2. Indistinct globular dome-like masses, with a harsh surface, were situated bet ween basement membrane of the retinal pigment epithelium and Bruch's membrane. These masses varied greatly in size. 3. Localized of dispersed small granular deposits of the inner collagen layer of Bruch's membrane were noted.
Aging ; Autopsy ; Basement Membrane ; Bruch Membrane ; Collagen ; Epithelium ; Freeze Fracturing ; Humans* ; Microscopy, Electron, Scanning* ; Retinal Pigment Epithelium ; Retinaldehyde ; Tissue Donors