Epidermolytic Hyperkeratosis is a rare variant of ichthyosis, transmitted as autosomal dominant inheritance. A 2-year-old male baby, in whom no hereditary back ground was found, showed typical clinical and histopathological features of Epiderrnolytic Hyperkeratosis. The possibility of occuring the disease without hereditary back grcund, clinical features, and histological characteristics of the disease are discussed.
Child, Preschool ; Humans ; Hyperkeratosis, Epidermolytic* ; Ichthyosis ; Male ; Wills

A case of Lupus vulgaris associated with scrofuloderma in a 11 year old girl is reported. The girl presented painless swellings, the left being more severe, on her both cheeks. A red, elevated, about 3 x 5 cm in size, partly eroded plaques is seen on her left cheek. On diascopy couple of so called apple jelly nodes are found within the plaque. A long linear red, scar like lesion is also found on her dlavicular area. Submandiblar lymph nodes are enlarged and hard. On right submandibular region there were two finger tip sized dome shaped red swellings which are connected with hard enlarged lymph nodes by cord like strings. The biopsy from left cheek disclosed typical picture of lupus vulgaris. The patient was refered to surgical clinic and was never seen again.
Biopsy ; Cheek ; Child ; Cicatrix ; Cytochrome P-450 CYP1A1 ; Female ; Fingers ; Humans ; Lupus Vulgaris* ; Lymph Nodes ; Tuberculosis, Cutaneous*

No abstract available.
Humans* ; Saponins* ; Skin*

Kimura's disease is a chronic inflammatory condition of unknown cause. It usually appears as a painless nodule in the head and neck region often associated with regional lymphadenopathy, but there have rarely been reports of penile involvement or clinical presentation as an ulcerative plaque. We present a case of Kimura's disease occurring on the penile shaft as an ulcerative plaque in a 44-year-old man. A vesicular eruption had occurred on his penile shaft followed by an ulcerative plaque for 2 months. He had suffered from recurrent regional lymphadenopathy for 15 years and he had also exhibited intermittent eosinophilia. Histopathologic findings revealed diffuse eosinophilic infiltration in the dermis of the skin and eosmophilic abscesses in the lymphoid follicles of the mguinal lymph node. After short-term systemic steroid therapy and local injection of triamcinolone acetonide, the ulcerative plaque was healed.
Abscess ; Adult ; Dermis ; Eosinophilia ; Eosinophils ; Head ; Humans ; Lymph Nodes ; Lymphatic Diseases ; Neck ; Skin ; Triamcinolone Acetonide ; Ulcer

A case of systemic coccidioidomycosis with cutaneous lesions has been found in Dec. 1974, for the first time in Korea, which is proved through cutaneous biopsy .and mycologic culture from skin lesion. The patient was 57-year-old Korean male. Skin lesions on left extremities showed several skin colored or ligbt brownish papules and surrounding circular erythematous scaly patches with slightly elevated borders. The patient was also found to have moderate diabetes mellitus, hypokalemia and resultant neuropathy. Histopathology revealed granulomatous lesions in the upper dermis, and numerous spherules both inside and outside of giant cells. Mycologic culture from grind skin specimen on Sabourauds glulose agar showed snow-white colony and ather typical arthrospores. Ampbotericin B intravenous injection was started and continued for 16 days. During a,dministration of the drug, side effects consisting of chills, fever, headache, chest pain and dyspnea developed. Therefore, further administration of the drug could not be done. During tbe several months following last discharge from the hospital, the patient has been, with no further specific therapy, in relatively good general condition, and developed no new lesions. The old papules have diminished in size, but did not disappear.
Agar ; Biopsy ; Chest Pain ; Chills ; Coccidioidomycosis* ; Dermis ; Diabetes Mellitus ; Dyspnea ; Extremities ; Fever ; Giant Cells ; Headache ; Humans ; Hypokalemia ; Injections, Intravenous ; Korea ; Male ; Middle Aged ; Skin

This study was intended to develop food and nutrition cyberclass contents for nonmajor students at university. We investigated universities which offered food and nutrition related courses in 1998 by a telephone survey in order to select the most appropriate lecture contents for the nonmajor university students. We investigated to select the most needed lecture contents for the students, 15 questions on evaluation of cyberclasses which they took. The number of subjects were 140 students of 'C' university who registered for nonmajor food and nutrition course in 1998. Among 140 students, 80 were cyberclass students and 60 were non cyberclass students. The results of the survey were as following : Fifty-five universities out of 62 had curriculums on food and nutrition in 1998 and 36,802 students attended the non major food and nutrition lectures. 84.9% of the respondents had their own computes and the main application mostly used was word processing. Additionally, 33.3% of them used on-line communications and 81.4% of them used internet. The most interesting subject of the respondents was 'disease and nutrition management'. The male respondents were concerned more about 'alcohol and health', whereas the females were concerned about 'obesity and weight control'.
Curriculum ; Surveys and Questionnaires ; Female ; Humans ; Internet ; Lectures ; Male ; Telephone ; Word Processing

This study was to investigate the changes in nutrition knowledge, nutrition attitude and food habit during 'meal management and diet' course to nonmajor university students by questionnaires. 280 students of Chungnam university who registered nonmajor 'meal management and diet' course in the 2003 were the subjects. The results of this study are as follows. BMIs of male and female students were 21.5 and 19.3. According to BMI, underweight subjects were 24.3%, normal and overweight (danger & obesity) subjects were each 62.4% and 13.6%, respectively. The nutrition knowledge scores significantly (p < 0.001) increased from 12.1 to 14.0 after the lecture, and the uncertainty rate of nutrition knowledge decreased significantly. Also, there were no significant differences in nutrition attitude score (39.5 to 39.8 points). Female subjects showed significantly (p < 0.05) higher nutrition knowledge scores (12.3 points) than male (11.4 points). 20% of the subjects smoked and 82.9% had alcohol drinks and 24.4% exercised more than 3 times per week. The subjects who ate regular meals significantly increased from 9.3 to 12.5% after the lecture, and smoking subjects decreased from 20 to 13%, but alcohol drinking subjects did not changed significantly.
Alcohol Drinking ; Chungcheongnam-do ; Diet* ; Education* ; Female ; Food Habits ; Humans ; Male ; Meals ; Overweight ; Smoke ; Smoking ; Thinness ; Uncertainty ; Surveys and Questionnaires

In vascular smooth muscle cells (VSMCs), induction of the heme oxygenase-1 (HO-1) confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) that is involved in negative regulation of cellular proliferation. In the present study, we investigated whether the phytochemical curcumin and its metabolite tetrahydrocurcumin could induce HO-1 expression and growth inhibition in rat VSMCs and, if so, whether their antiproliferative effect could be mediated via HO-1 expression. At non-toxic concentrations, curcumin possessing two Michael-reaction acceptors induced HO-1 expression by activating antioxidant response element (ARE) through translocation of the nuclear transcription factor E2-related factor-2 (Nrf2) into the nucleus and also inhibited VSMC growth triggered by 5% FBS in a dose-dependent manner. In contrast, tetrahydrocurcumin lacking Michael-reaction acceptor showed no effect on HO-1 expression, ARE activation and VSMC growth inhibition. The antiproliferative effect of curcumin in VSMCs was accompanied by the increased expression of p21(WAF1/CIP1). Inhibition of VSMC growth and expression of p21(WAF1/CIP1) by curcumin were partially, but not completely, abolished when the cells were co- incubated with the HO inhibitor tin protoporphyrin. In human aortic smooth muscle cells (HASMCs), curcumin also inhibited growth triggered by TNF-alpha and increased p21(WAF1/CIP1) expression via HO-1-dependent manner. Our findings suggest that curcumin has an ability to induce HO-1 expression, presumably through Nrf2-dependent ARE activation, in rat VSMCs and HASMCs, and provide evidence that the antiproliferative effect of curcumin is considerably linked to its ability to induce HO-1 expression.
Active Transport, Cell Nucleus ; Animals ; Aorta/cytology ; Cell Nucleus/metabolism ; Cell Proliferation/*drug effects ; Cells, Cultured ; Curcumin/analogs & derivatives/*pharmacology ; Cyclin-Dependent Kinase Inhibitor p21/biosynthesis/metabolism ; Gene Expression Regulation ; Heme Oxygenase (Decyclizing)/biosynthesis/genetics/*physiology ; Heme Oxygenase-1/biosynthesis/genetics/*physiology ; Humans ; Metalloporphyrins/pharmacology ; Muscle, Smooth, Vascular/drug effects/*physiology ; Myocytes, Smooth Muscle/drug effects/*physiology ; NF-E2-Related Factor 2/metabolism ; Protoporphyrins/pharmacology ; Rats ; Regulatory Sequences, Nucleic Acid ; Response Elements ; Tumor Necrosis Factor-alpha/pharmacology

Hypoxia-inducible factors (HIFs) are transcription factors that activate the transcription of target genes involved in crucial aspects of cancer development. This study investigated the expression of HIFs and their contribution to the regulation of target genes related to angiogenesis and glucose metabolism in gastric cancer. The data showed that HIFs were over-expressed in gastric cancer and that activation of the target genes was observed mainly in the early stages. Moreover, the results of the present study revealed that only HIF-1alpha, but not HIF-2alpha dimerizes with HIF-1beta and then regulates expression of target genes in response to hypoxia. The results of the present study demonstrate that HIF-1alpha and HIF-1beta enhances expression of VEGF and glucose metabolism-related genes in response to hypoxia in gastric cancer. These data offer important information regarding HIF pathways in the development of gastric cancer.
Aryl Hydrocarbon Receptor Nuclear Translocator/*genetics/metabolism ; Basic Helix-Loop-Helix Transcription Factors/*genetics/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Glucose/*metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/*genetics/metabolism ; Neovascularization, Pathologic/genetics/metabolism ; Stomach Neoplasms/*genetics/metabolism ; Vascular Endothelial Growth Factor A/*genetics/metabolism

OBJECTIVE: The main complaints of users in existing electronic medical record systems are the complexity of recording system and long recording time. The records of patient moving and the diagnostic test performed outside emergency room are important. But emergency nurses can't record such information exactly and completely because of the highest priorities of emergency treatment and its record in overcrowded emergency room. METHODS: Emergency electronic medical record team of Asan Medical Center developed the automatic recording system of patient moving and diagnostic test information in 2006. The effectiveness of this system was evaluated by comparing the number of records in manual and automatic documentations before and after the system application. RESULTS: The numbers of total records per patient-order were not changed statistically, but the number of manual patient moving and diagnostic test records significantly reduced from 0.50+/-0.69 to 0.31+/-0.47 (p < 0.01). The number of automatic patient moving and diagnostic test records per patient-order was 1.98+/-0.99. CONCLUSION: This automatic recording system can reduce indirect nursing time and give more exact and complete information to emergency medical personnel. The effort to simplify documentation in electronic medical record systems is important, but 'automatic recording' strategy is also needed.
Automation ; Chungcheongnam-do ; Diagnostic Tests, Routine* ; Documentation ; Electronic Health Records ; Emergencies* ; Emergency Service, Hospital* ; Emergency Treatment ; Humans ; Moving and Lifting Patients* ; Nursing*