Purpose: The objective of this study was to investigate how meaning in work influences the connection between wellness and job satisfaction among police officers. Methods: This study analyzed secondary data. Original data was collected to explore changes in depression, job satisfaction, and quality of life in relation to police officers' psychological trauma. Data were analyzed using the t-test, One-way Analysis of Variance, Pearson’s correlation coefficient, hierarchical regression analysis, and PROCESS macro (version 4.3.1) with the SPSS/27.0 program. Results: The mean score for wellness was 3.40, meaning in work was 3.49, and job satisfaction was 3.36. The effect size of the mediation was indicated as 0.74, demonstrating that the meaning in work serves as a partial mediator in the relationship between wellness and job satisfaction among police officers. Conclusion These findings indicate that wellness and meaning in work increased job satisfaction among police officers. Therefore, to increase job satisfaction among police officers, it is necessary to develop psychiatric nursing intervention strategies to increase wellness and meaning in work.