This study was performed to estimate the effect of alphacalcidol supplementation or nutrition education on the nutrient intakes, bone mineral density and bone markers in continuous ambulatory peritoneal dialysis (CAPD) patients. The 90 CAPD subjects were randomly assigned to 3 groups (alphacalcidol group: AG, nutrition education group: NG, and control group: CG). Alphacalcidol supplementation(0.5 microgram/day) was carried out for 8 months. Nutrition counseling was performed according to the patient's individual question for the first 6 months and scheduled nutrition education with individual counseling was carried out for the last 2 months. In baseline data, there were no significant differences in age, sex, family number, education years and monthly income except the NG showed significantly less duration of CAPD (p <0.05) compared to other two groups. After intervention all three groups showed tendency of lower intakes. NG revealed less decrease in protein, especially in animal protein, calcium from Ca-P binder, dietary calcium, dietary iron and niacin. NG showed significantly more increase in dry weight (p <0.05) and AG in waist circumference (p <0.001) after intervention. The groups did not show significant differences in the changes of biochemical indices related to bone metabolism. NG revealed more increase in trochanter BMD (p <0.05) compared to other two groups. It seems that nutrition education is more effective in preventing deterioration or improving the bone and general nutrition status.
Animals ; Bone Density* ; Calcium ; Calcium, Dietary ; Counseling ; Education* ; Femur ; Humans ; Iron, Dietary ; Metabolism ; Niacin ; Nutritional Status ; Peritoneal Dialysis, Continuous Ambulatory* ; Waist Circumference

The present study was performed to evaluate clinical manifestations in 26 patients and histopathological findings in 19 patients with Behcets syndrome. 1. Clinical findings: A. Among the 26 patients, 9 were male and 17 were female (male to female ratio was 1: l.9). The age at onset of the disease varied from 10 to 62, with a mean of 26.9. B. The incidence of the major clinical manifestations: The oral ulcers were observed in all of the 26 patients, genital ulcers in 21 patients (81%), cutaneous manifestations in 25 patients (96%) and ocular lesions in 7 patients (27%). C. Saline intradermal test was positive in 62% and PPD intradermal test in 42% 2. Histopathological findings: Fourty-one specimens were taken frorn 19 patients with Behcets syndrome; Erythema nodosum like lesions (15), edematous papules (3), acneiform eruption (1), oral ulcers (4), genital ulcers (8), saline intradermal injection sites (5) and PPD intradermal test sites (5). As a control, 4 specirnens were taken from PPD test sites of the patients with erythem nodosum. The common histopathological findings were perivascular inflammatory cell infiltration, mainly composed of neutrophils and nuclear dusts, and vasculitis of varying degree. A. Cutaneous lesions; In erythema nodosum-like lesions main pathologic foci were in the deep dermis and/or the subcutis, and moderate to severe vasculitis were observed. In edematous papules, however, main foci were in the pa,pill- ary dermis and the upper dermis, papillary dermal edema was prorninent, and vasculitis was rather mild.
Acneiform Eruptions ; Behcet Syndrome* ; Dermis ; Dust ; Edema ; Erythema ; Erythema Nodosum ; Female ; Humans ; Incidence ; Injections, Intradermal ; Intradermal Tests ; Male ; Neutrophils ; Oral Ulcer ; Ulcer ; Vasculitis

Subepiderral calcified nodules is a special form of idiopathic calcinosis circumscripta with its distinct clinical and histopathologic features, which was originally described by Winer(1952) as solitary congenital no3ular czlcification of the skin. Although the lesions are usually solitary and congenital, subs aquent investigators reported multiple lesions and later onset. Clinically, th. leions are small hard. yellowish-white warty nodules developed. usually on the face and mostly in children and histopathologically are subepidermal calcified mass with s cvn4ry epidermal changes. Although the pathogenesis is still unexplained, it s seems that the disease is not associated with any systemic or cutaneous disease or any biochemial abnormalities. We present a first recorded case of subepidermal calcified no3ules developed on the left the a Korasn female, aged 23, which has been present for 7 years. Shave biopsy showed typical histopathologic and histochemical features of the subpidermal calcified nodules. Literature were reviewed.
Biopsy ; Calcinosis ; Child ; Female ; Humans ; Research Personnel ; Skin

Roots of manually extracted scalp hairs among 86 healthy Koreans in different age groups were examined microscopically and the proportion of resting hairs to growing hairs were determined with the fol[owing results. 1. The proportion of resting hairs in all age groups was 10. 9% and there was no significant difference between male and female. 2. In each age group the proportion of resting hairs show's difference, being lowest (6. 8%) in below 9 years age group, increasing the rate by increasing the age group, highest (19. 7%) in over 60 years age group. 3. The proportion of resting hairs below the age of 29 years was below 10%, above 30 years to 49 years in between 10% to 15% and over 50 years in between 15% to 20%. 4. The normal range of the proportion of resting hairs among normal Koreans was below 20%.
Dermatitis, Atopic* ; Female ; Hair ; Humans ; Male ; Neutrophils* ; Reference Values ; Scalp

The serum value of immunoglobulin E (IgE) in 47 cases of atopic dermatitis and 43 cases of urticaria were determined by Phadebas PRIST(R) method in department of dermatology at National Medical Center, from Jan., 1982 to Sep., 1982. The results were as follow; 1. The mea,n IgE value in atopic dermatitis was significantly higher (408+/-l43 u/ml) than that of normal subjects (p>0.01). 2. The mean value of IgE in urticaria (310+/-299 u/ml) was not significantly higher than tha,t of normal subjects (p>0.05). 3. The rnean value of IgE in severely expanded atopic dermatitis (664+/-404 u/ml) was significantly increased than that of normal subjects (p>0.01) 4. The mean value of IgE in 7 cases of atopic dermatitis with allergic respiratory diseases (817+/-233 u/ml) was significantly elevated (p>0.01). 5. No close correlation was seen between IgE value and eosinophilia. 6. IgE in 2 cases of the urticaria infested with PW, CS were extended over 1000u/ml.
Dermatitis, Atopic ; Dermatology ; Eosinophilia ; Immunoglobulin E* ; Immunoglobulins ; Skin Diseases* ; Urticaria

A 24-year-old female who have had pseudoxanthoma elasticum for 14 years, showed brownish, umbilicated papules forming serpiginous pattern on the anterior neck, A skin biopsy specimen from the neck lesion revealed epidermal hyperplasia and perforating canal containing basophilic, necrotic materials and degenerated elastic fibers, also showed short, swollen and irregularly clumped elastic fibers in the lower dermis.
Basophils ; Biopsy ; Dermis ; Elastic Tissue ; Female ; Humans ; Hyperplasia ; Neck ; Pseudoxanthoma Elasticum* ; Skin ; Young Adult

The nevua of Ota is a congenital pigmentary disorder of the skin and mucaus membrane, partieularly in the periorbital region, the temple, the forehead, the malar area and the nose. The nevus of Ita differs from the nevus of Ota in its distribution in the supraclavicular, scapular, and deltoid regions. It may occur alone or in association with ipsilateral or rarely with bilateral nevus of Ota. We present a 22 year-old female who has had pigmentary anomalies on the both malar areas and left sclera associated with pigmentation of the right shoulder.
Female ; Forehead ; Humans ; Membranes ; Nevus of Ota* ; Nevus* ; Nose ; Pigmentation ; Sclera ; Shoulder ; Skin ; Young Adult

No abstract available.
Eczema* ; Kaposi Varicelliform Eruption*

There have been no standard treatments for recurrent aphthous stomatitis, and clinical management is usually directed toward symptomatic relief. Recent immunological investigations have focused on possible imrnunopathogenesis of the disease. Several reparters suggested that levamisole, nonspecific immune-stimulator, had a beneficiaI effect in controlling attacks of recurrent a,phthous stomatitis and in reducing subsequent episodes. The present study was undertaken to evaluate the therapeutic effectiveness of levamisole in patients with recurrent aphthous stomatitis. A total of 8 patients who had had recurrent aphthous stomatitis for 2 to 20 years and who had experienced at least one episode per month were selected for this study from the department of dermatology, National Medical Center, through March 1979 to September 1979, Levamisole (Decaris') was given 150mg, p.o., once daily on 3 consecutive days every week for 2 months. Tbe results were as follows. 1) One patient had to have levamisole discontinued due to a high fever and exacerbations of tbe oral ulcerations. 2) 5 patients showed beneficial effects in reducing tbe number, frequency, pain and severity of recurrent aphthous stomatitis. 3') One patient showed no therapeutic response. 4) One patient, who has experienced new oral ulcerations continuously before starting levamisole, showed no recurrences of the lesions during the follow-up period of 3 months. 5) Side effects during levamisole administration were transient and generally mild, They included nausea, headache, dizziness and high fever.
Dermatology ; Dizziness ; Fever ; Follow-Up Studies ; Headache ; Humans ; Levamisole* ; Nausea ; Oral Ulcer ; Recurrence ; Stomatitis ; Stomatitis, Aphthous*

Prurigo nodularis is a troublesome chronic dermatosis that showed unsatisfactory response to conventional therapies. Since thalidomide has been applied to the treatment of prurigo nodularis, although the action mechanism is still uncertain, many dermatologists have confirmed its effectiveness. We treated a 54-year-old male patient who had prurigo nodularis affecting the whole body for 10 years with 100 to 300mg of thalidomide daily as the sole therapy for 4 months. The skin lesions were flattened leaving postinflammatory hyperpigmentation and the pruritus also sub-sided. Two years after stopping thalidomide, no recurrence was observed.
Humans ; Hyperpigmentation ; Male ; Middle Aged ; Prurigo* ; Pruritus ; Recurrence ; Skin ; Skin Diseases ; Thalidomide*