Objective: Depending on the direction and degree of the septal deviation, the patient with malalignment-type VSD present with a variety of clinical syndrome. It is the purpose of this study to examine clinical characteristics of malalignment-type VSD, and to emphasize the clinical significance of septal malalignment in VSD and thus to increase the awareness for it. Methods: We analyzed echocardiographic or cardic catheterization and angiographic findings of 85 patients who were diagnosed as malalignment-type VSD at the department of pediatrics, Chonnam University Hospital between July 1990 and September 1992 Results: 1) Among 85 patients with malalignment-type VSD, there were 52 Cases (61. 2%) of Fallot-type VSD. 14 cases (16.5%) of Eisenmenger-type VSD, 19 cases (22.3%) of coarctation-type VSD. 2) All the 85 cases with malalignment-type VSD had the infundibular defects, and perimembranous infundibular VSD was most frequently associated with septal malalignment. 3) There was no prolapsing valve in all the cases with malalignment-type VSD. 4) Pulmonary hypertension was observed in all the cases with Eisenmenger-type and coarctation-type VSD. 5) Among the 19 cases with coarctation-type VSD, 8 cses (42.1%) were associated with coarctation of the aorth, and 3 cases (15.8%) with interrupted aortic arch. Conclusion: We conclude that septal malalignment in VSD has considerable clinical significance. Therefore, the authors believe that we should always consider the presence or absence of septal malalignment, in addition to the size and location of defect at the time of diagnostic evaluation of VSD, especially in the Koreans showing high incidence of infundibular VSD.
Aorta, Thoracic ; Catheterization ; Catheters ; Echocardiography ; Heart Septal Defects, Ventricular* ; Humans ; Hypertension, Pulmonary ; Incidence ; Jeollanam-do ; Pediatrics

Recently there is increasing tendency of the nosocomial infection, and Pseudomonas aeruginosa is one of the most important and common pathogens causing hospital opportunistic infections with rapid emergence of resistant strain especially in immunologically compromised patients. An experimental study for the effects of polyvalent Pseudomonas vaccine was performed in an animal model of Pseudomonas sepsis on a survival rates and histopathological points of view-using ICR inbred mice. The vaccine was prepared with heat killed whole cells of the 10 representative serotypes of Pseudomonas aeruginosa, which were isolated from the Department of Microbiology, College of Medicine, Kyung Hee University and Seoul National University, and they were devided into two polyvalent vaccine groups. The animal model of the Pseudomonas sepsis was deveoped by intravenous inoculation of Pseudomonas aeruginosa (serotype F, inoculum size 100 microliter, 109 cells/ml), immediately after cutaneous burns. The results were as follows. 1) The survival rate of the immune mice was 100% and that of non-immune mice was 60%. 2) The histologic findings of lung of the non-immune mice were severe congestion (18/18 mice), hemorrhage (18/18 mice), emphysematous change (18/18 mice), thrombosis (9/18 mice), infarction (9/18 mice) and inflammation (6/18 mice) and those of the immune mice were only congestion (6/20 mice) and focal emphysematous change (2/20) from the 3 day experimental group. 3) The histologic findings of the liver in the non-immune mice were severe congestion, Kupffer cell mobilization, focal necrosis, & portal inflammation in most of them, and from 7 day experimental group there were noted infiltrations of lagre histiocytic cells in sinusoids, and those in the immune mice were only reactive change of varying degree. 4) The histologic findings of the spleen in the non-immune mice were severe reactive hyperplasia in all and ischemic necrosis in about half of them, and those in the immune mice were only reactive change. 5) The histologic findings of the heart in the non-immune mice were severe congestion and inflammation in most and in the immune mice were only occasional nonspecific congestion. 6) The histologic findings of the kidney in the non-immune mice were severe congestion in all, interstitial inflammation, acute tubular necrosis and cortical necrosis in about half of them, and those in the immune mice were only mild congestion. With the above results, we can suspect there is a significant protective effects of the polyvalent pseudomonas vaccine on the pseudomonas sepsis in ICR mice.
Mice ; Animals

Scute/larisa baica/ensis (SB) has been used as a folk medicine for curing ulcer, inflammation and infection. However, surprisingly little has been done to develop and exploit SB's immunomodulating, anti- inflammatory properties. Moreover, the mechanisms of SB-action on immune function had not been elucidated. The present study was undertaken to investigate the effect of 5B on immune functions, microbial growth and bacterial mutagenicity. Boiling water extract of SB was used in this experiment. The proliferation response to PHA-, Con A- or LPS-stimulation and the production of Con A-induced IL-2 and LPS-induced IL-6 of splenocytes from SB-pretreated mice were significantly higher than those of splenocytes from control mice. Daily single injection of 2 mg/mouse SB for 4 days resulted in enhancement of Arthus reaction and DTH to SRBC. And these enhancements were more prominent when SB was treated prior to SRBC- sensitization. SB did inhibit the growth of microorganisms such as C. albicans, C. neoformans, E. coli S. typhimurium and this inhibiting effect was gradually increased in proportion to the increment of SB. SB also remarkably reduced the mutagenicity of mutagens such as sodium azid and benzo[a]pyrene, but this was not certain, because it showed a killing effect on the cell survival test. When SB treated mice were i.p infected with C. albicans, the number of microorganisms in the peritoneal exudates were significantly reduced. Taken together, these results revealed that SB itself has not only multiple effects on events controlling immune responses but also anti-inflammatory properties, which may provide the rational basis for their therapeutic use as one of the biological response modifiers.
Animals ; Arthus Reaction ; Cell Survival ; Exudates and Transudates ; Homicide ; Immunologic Factors ; Inflammation ; Interleukin-2 ; Interleukin-6 ; Medicine, Traditional ; Mice ; Mutagens ; Scutellaria baicalensis* ; Scutellaria* ; Sodium ; Ulcer ; Water

No abstract available.
Animals ; Mice* ; Oocytes*

No abstract available.
Bipolar Disorder*

PURPOSE: This study was to examine the relationship of knowledge, health beliefs, and prevention behaviors of osteoporotic fracture in outpatients with osteoporosis. METHODS: The subjects were 120 outpatients receiving osteoporosis treatment on K hospital in G city from Dec. 2007 to Feb. 2008. Questionnaires were collected and analyzed using the SPSS/WIN 12.0 program for descriptive statistics, and t-test, ANOVA, and Pearson correlation coefficient. RESULTS: Subjects were treated for fracture about 28 months. The mean score of knowledge, health belief and prevention behaviors in subjects were 17.5 +/- 3.22, 2.8 +/- 0.23 and 2.8 +/- 0.38 respectively. The score of health belief recorded the lowest point. However, the score of knowledge varied with general and disease-related characteristics of subjects. In contrast, the score of prevention behaviors did not showed any significant differences. Fracture prevention behavior in subjects showed rather higher relationship with the health belief system than the knowledge of fracture prevention. CONCLUSION: The present work suggested that education program for prevention behaviors of fracture should be developed to focus on altering the health belief system rather than the knowledge of osteoporotic fracture prevention. Furthermore, individual education program based on living circumstances and daily life habits should be also developed.
Humans ; Osteoporosis ; Osteoporotic Fractures ; Outpatients ; Surveys and Questionnaires

No abstract available.
Intuition* ; Nursing* ; Philosophy*

No abstract available.
Hemoglobinuria, Paroxysmal*

No abstract available.
Otitis Externa* ; Tomography, Emission-Computed, Single-Photon*

No abstract available.
Aneurysm, False*