1.An Open-Label Study of the Improvements in Clinical Symptoms and Neurocognitive Functions in Korean Children and Adolescents with Attention-Deficit Hyperactivity Disorder after Treatment with Metadate CD.
Hanik K YOO ; Bongseog KIM ; Yoo Sook JOUNG ; Geon Ho BAHN ; Dong Ho SONG ; Dong Hyun AHN ; Young Sik LEE
Journal of the Korean Academy of Child and Adolescent Psychiatry 2011;22(4):253-261
OBJECTIVES: This study aimed to investigate the efficacy and safety of Metadate CD (MCD) when given to Korean children and adolescents with attention-deficit hyperactivity disorder (ADHD). We also explored the effects of the drug on diverse neurocognitive functions. METHODS: Ninety-one subjects with ADHD (mean age 8.6+/-2.2 years) were recruited at 6 outpatient clinics in Seoul, Korea. We used the ADHD Rating Scale (ARS), Clinical Global Impression (CGI), and comprehensive attention test (CAT) to measure the drug's effects. RESULTS: After 0.92+/-0.32mg/kg/day of MCD were administered for 57.4+/-7.6 days, there was a 48.5% reduction in the mean total ARS scores (p<.001). Fifty-seven subjects (64.8%) showed either much improved or very much improved outcomes on the CGI-Improvement scale. The CGI-Severity scale also decreased from an average of 4.7 to an average of 2.9 (p<.001). Errors and response time standard deviations of the CAT, sustained attention test-to-response tasks, the flanker test, and divided attention test scores decreased after treatment (p<.05). The forward memory span of the spatial working memory test scores increased (p<.05). Thirty-five patients (39.8%) experienced side effects, of which the most common were headache (14.8%), nausea (12.5%), and anorexia (9.1%). CONCLUSION: This open-label study suggests that MCD is effective and safe in improving the symptoms and neurocognitive functions of Korean children and adolescents with ADHD.
Adolescent
;
Ambulatory Care Facilities
;
Animals
;
Anorexia
;
Cats
;
Child
;
Corneal Dystrophies, Hereditary
;
Headache
;
Humans
;
Korea
;
Memory
;
Memory, Short-Term
;
Methylphenidate
;
Nausea
;
Reaction Time
2.An Open-Label Study of the Improvements in Clinical Symptoms and Neurocognitive Functions in Korean Children and Adolescents with Attention-Deficit Hyperactivity Disorder after Treatment with Metadate CD.
Hanik K YOO ; Bongseog KIM ; Yoo Sook JOUNG ; Geon Ho BAHN ; Dong Ho SONG ; Dong Hyun AHN ; Young Sik LEE
Journal of the Korean Academy of Child and Adolescent Psychiatry 2011;22(4):253-261
OBJECTIVES: This study aimed to investigate the efficacy and safety of Metadate CD (MCD) when given to Korean children and adolescents with attention-deficit hyperactivity disorder (ADHD). We also explored the effects of the drug on diverse neurocognitive functions. METHODS: Ninety-one subjects with ADHD (mean age 8.6+/-2.2 years) were recruited at 6 outpatient clinics in Seoul, Korea. We used the ADHD Rating Scale (ARS), Clinical Global Impression (CGI), and comprehensive attention test (CAT) to measure the drug's effects. RESULTS: After 0.92+/-0.32mg/kg/day of MCD were administered for 57.4+/-7.6 days, there was a 48.5% reduction in the mean total ARS scores (p<.001). Fifty-seven subjects (64.8%) showed either much improved or very much improved outcomes on the CGI-Improvement scale. The CGI-Severity scale also decreased from an average of 4.7 to an average of 2.9 (p<.001). Errors and response time standard deviations of the CAT, sustained attention test-to-response tasks, the flanker test, and divided attention test scores decreased after treatment (p<.05). The forward memory span of the spatial working memory test scores increased (p<.05). Thirty-five patients (39.8%) experienced side effects, of which the most common were headache (14.8%), nausea (12.5%), and anorexia (9.1%). CONCLUSION: This open-label study suggests that MCD is effective and safe in improving the symptoms and neurocognitive functions of Korean children and adolescents with ADHD.
Adolescent
;
Ambulatory Care Facilities
;
Animals
;
Anorexia
;
Cats
;
Child
;
Corneal Dystrophies, Hereditary
;
Headache
;
Humans
;
Korea
;
Memory
;
Memory, Short-Term
;
Methylphenidate
;
Nausea
;
Reaction Time
3.Clinical and MRI Profiles Predicting Clinical Overt Stroke in Patients with CADASIL.
Jung Seok LEE ; Jay Chol CHOI ; Sa Yoon KANG ; Sook K SONG ; Ji Hoon KANG ; Jung Kook SONG ; Hae Ri NA
Journal of the Korean Neurological Association 2012;30(2):93-99
BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited arteriopathy caused by mutation in the Notch 3 gene. Cognitive impairment, which is the second most frequent clinical manifestation, worsens with recurrent stroke. Comparison studies between the pre- and poststroke phases in CADASIL have not yet been performed in Asia. Here we describe the clinical characteristics of both the preand poststroke phases and identified the risk factors for stroke in CADASIL. METHODS: Fifty-three consecutive patients were investigated. Patients were divided into two groups depending on the presence (poststroke group; n=31) or absence (prestroke group; n=22) of clinically overt stroke. All patients underwent an MRI scan with the same protocol. Cognition was assessed by applying detailed neuropsychological tests. RESULTS: The poststroke group exhibited an increase in lacunae and cerebral microbleeds. The memory scores on the Alzheimer's Dementia Assessment Scale cognitive subscale and the number of correct Stroop color-naming scores were lower in the poststroke group than in the prestroke group. Hypertension was more prevalent in the poststroke group, while chronic headache was more prevalent in the prestroke group. CONCLUSIONS: These findings suggest that cerebral microbleeds as well as lacunae predict the risk of clinically overt stroke, which leads to a worsening of frontal-lobe function in CADASIL.
Asia
;
CADASIL
;
Cognition
;
Dementia
;
Headache Disorders
;
Humans
;
Hypertension
;
Magnetic Resonance Imaging
;
Memory
;
Risk Factors
;
Stroke
4.Primary Central Nervous System Lymphoma Mimicking Behcet's Disease.
Joong Goo KIM ; Sook K SONG ; Jay Chol CHOI ; Sa Yoon KANG ; Ji Hoon KANG ; Jung Seok LEE
Journal of the Korean Neurological Association 2012;30(3):235-237
No abstract available.
Central Nervous System
;
Lymphoma