Gaucher disease is the most common lysosomal storage disorder. Resveratrol is a natural polyphenol that possesses a wide range of beneficial effects, including anti-inflammatory, anti-oxidant, and neuroprotective activities. The aim of this study was to determine if resveratrol has a therapeutic effect on primary fibroblast cells derived from a patient with type III Gaucher disease. 3-(4,5- Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays were performed to determine the effect of resveratrol on cell survival. The expression levels of apoptosis-inducing factor (AIF), Bcl-2-associated X protein (Bax), caspase-3, acetyl-coenzyme A acetyltransferase 1 (ACAT1), E3- binding protein (E3BP), and citrate synthase (CS) were evaluated by western blotting to characterize the effect of resveratrol treatment on Gaucher disease cells. Thin-layer chromatography (TLC) was carried out to measure changes in glucosylceramide levels in resveratrol-treated patient cells. Resveratrol increased the viability of patient cells compared to that of untreated control cells. Resveratrol treatment dose-dependently decreased AIF, Bax, and cleaved caspase-3 levels, whereas ACAT1, E3BP, and CS expression dose-dependently increased. TLC analysis showed reduced levels of glucosylceramides in resveratrol-treated patient cells. These findings demonstrate that resveratrol can relieve cellular stress due to glucosylceramide accumulation, and suggest that it should be studied further as a new therapeutic approach for the treatment of Gaucher disease.
Gaucher Disease

PURPOSE: The purpose of this study was to examine effects of a positive psychology program for improving positive thinking, ego resilience and stress coping of in nursing students. METHODS: A non-equivalent control group pretest-posttest design was used. The subjects for the study were 78 students in G city(experimental group=41, control group=37). The positive psychology program was provided for 4 weeks (8 sessions, 16 hours). Positive thinking, ego resilience, and stress coping were measured with using self-report structured questionnaires. This study collected data between November 23, 2014 and January 9, 2015, and which were analyzed using SPSSWIN 20.0. RESULTS: The positive psychology program was effective in increasing positive thinking, ego resilience and stress coping. CONCLUSION: The results of this study should contribute as baseline data for positive intervention strategies and planning ability of potentials and strengths in nursing students.
Ego* ; Humans ; Nursing* ; Psychology* ; Students, Nursing ; Thinking*

OBJECTIVES: The aim of this study was to examine the effects of maternal sociodemographic characteristics, especially education and employment, and parenting stress on the child's self-concept. Attention was also paid to the mediating impact of parenting style on the relationship between the maternal variables and a child's self-concept. METHODS: A questionnaire and three scales were completed by fifth graders and their mothers, and 270 sets of paired data were analyzed. RESULTS: The results showed that mothers with higher education experienced less child-related parenting stress, were perceived to be more achievement-oriented and rational by their children, and also had children with more positive selfconcept. The relationship between maternal education and child's self-concept was mediated by the rationality dimension of parenting style. Maternal employment was not related to parenting stress, parenting style and most aspects of the child's self-concept. Lastly, child-related parenting stress had a negative effect on the child's self-concept, and this effect was mediated by the warmth and rationality dimensions of parenting style. CONCLUSION: Parenting style had a mediating effect on the relationships between the child's self-concept and maternal education and child-related parenting stress.
Child ; Employment ; Humans ; Mothers ; Negotiating ; Parenting ; Parents ; Weights and Measures ; Surveys and Questionnaires

Purpose: The purpose of this study was to assess postoperative complications and factors influencing complications in lung cancer patients undergoing therapeutic lung resection. Methods: This was a retrospective comparative study investigating participants’ individual characteristics, nutritional status, operative characteristics, and disease characteristics as found in the electronic medical records of patients undergoing therapeutic lung resection for lung cancer. Data were collected from 191 participants who received the therapeutic lung resection in 1 general hospital. Analysis was done using x2 test or independent t-test, Pearson correlation and multiple regression analysis. Results: The incidence of complications according to the characteristics of the patients was significantly higher for men over 65 years old, smokers (former smokers included), FEV1/FVC ratio less than 70%. Other factors influencing outcomes were lengthy operation time, FEV1/FVC ratio less than 70% and post OP stageII. Conclusion Results show that a FEV1/FVC ratio less than 70%, and post OP stageII are factors influencing complications after therapeutic lung resection. Determination of chronic obstructive pulmonary disease through preoperative pulmonary function tests and plans to provide nursing interventions that improve lung function contribute to prevention of postoperative complications.

Purpose: To report a case of orbital apex syndrome resulting from invasive fungal sinusitis attributed to the unusual Candida glabrata species.Case summary: A 76-year-old patient presented with persistent left-sided orbital pain, headaches, and blurred vision for 3 weeks. The patient had a history of uncontrolled diabetes, chronic kidney failure, and angina, and was treated for a COVID-19 infection 1 month prior to admission. Contrast-enhanced computed tomography scans revealed extensive bilateral sinusitis affecting the left optic nerve. The patient underwent endoscopic sinus surgery, which included nasal cavity biopsy, conducted by an otorhinolaryngologist. Histopathological analysis using Gömöri methenamine silver stains identified Candida. Cultures from sinus specimens later grew Candida glabrata. Treatment involved daily IV amphotericin B followed by oral itraconazole. After 6 months, the patient fully recovered from fungal sinusitis but continued to experience negative light perception in the left eye and progressed to complete ophthalmoplegia, consistent with orbital apex syndrome. Conclusions Reports of invasive fungal sinusitis caused by Candida infections are rare globally. This report marks the first occurrence in this country. Effective management requires careful assessment and appropriate treatment tailored to the specific species, especially considering the risk of orbital extension of the inflammatory lesion.

Purpose: To report a case of orbital apex syndrome resulting from invasive fungal sinusitis attributed to the unusual Candida glabrata species.Case summary: A 76-year-old patient presented with persistent left-sided orbital pain, headaches, and blurred vision for 3 weeks. The patient had a history of uncontrolled diabetes, chronic kidney failure, and angina, and was treated for a COVID-19 infection 1 month prior to admission. Contrast-enhanced computed tomography scans revealed extensive bilateral sinusitis affecting the left optic nerve. The patient underwent endoscopic sinus surgery, which included nasal cavity biopsy, conducted by an otorhinolaryngologist. Histopathological analysis using Gömöri methenamine silver stains identified Candida. Cultures from sinus specimens later grew Candida glabrata. Treatment involved daily IV amphotericin B followed by oral itraconazole. After 6 months, the patient fully recovered from fungal sinusitis but continued to experience negative light perception in the left eye and progressed to complete ophthalmoplegia, consistent with orbital apex syndrome. Conclusions Reports of invasive fungal sinusitis caused by Candida infections are rare globally. This report marks the first occurrence in this country. Effective management requires careful assessment and appropriate treatment tailored to the specific species, especially considering the risk of orbital extension of the inflammatory lesion.

Purpose: To report a case of orbital apex syndrome resulting from invasive fungal sinusitis attributed to the unusual Candida glabrata species.Case summary: A 76-year-old patient presented with persistent left-sided orbital pain, headaches, and blurred vision for 3 weeks. The patient had a history of uncontrolled diabetes, chronic kidney failure, and angina, and was treated for a COVID-19 infection 1 month prior to admission. Contrast-enhanced computed tomography scans revealed extensive bilateral sinusitis affecting the left optic nerve. The patient underwent endoscopic sinus surgery, which included nasal cavity biopsy, conducted by an otorhinolaryngologist. Histopathological analysis using Gömöri methenamine silver stains identified Candida. Cultures from sinus specimens later grew Candida glabrata. Treatment involved daily IV amphotericin B followed by oral itraconazole. After 6 months, the patient fully recovered from fungal sinusitis but continued to experience negative light perception in the left eye and progressed to complete ophthalmoplegia, consistent with orbital apex syndrome. Conclusions Reports of invasive fungal sinusitis caused by Candida infections are rare globally. This report marks the first occurrence in this country. Effective management requires careful assessment and appropriate treatment tailored to the specific species, especially considering the risk of orbital extension of the inflammatory lesion.

Purpose: To report a case of orbital apex syndrome resulting from invasive fungal sinusitis attributed to the unusual Candida glabrata species.Case summary: A 76-year-old patient presented with persistent left-sided orbital pain, headaches, and blurred vision for 3 weeks. The patient had a history of uncontrolled diabetes, chronic kidney failure, and angina, and was treated for a COVID-19 infection 1 month prior to admission. Contrast-enhanced computed tomography scans revealed extensive bilateral sinusitis affecting the left optic nerve. The patient underwent endoscopic sinus surgery, which included nasal cavity biopsy, conducted by an otorhinolaryngologist. Histopathological analysis using Gömöri methenamine silver stains identified Candida. Cultures from sinus specimens later grew Candida glabrata. Treatment involved daily IV amphotericin B followed by oral itraconazole. After 6 months, the patient fully recovered from fungal sinusitis but continued to experience negative light perception in the left eye and progressed to complete ophthalmoplegia, consistent with orbital apex syndrome. Conclusions Reports of invasive fungal sinusitis caused by Candida infections are rare globally. This report marks the first occurrence in this country. Effective management requires careful assessment and appropriate treatment tailored to the specific species, especially considering the risk of orbital extension of the inflammatory lesion.

Purpose: This study aimed to assess the difference in the vascular parameters of perfusion in the optic nerve head in normal tension glaucoma (NTG) across disease stages using optical coherence tomography angiography and its correlation with peripapillary retinal nerve fiber layer (RNFL) thickness. Methods: In this retrospective study, 83 eyes with varying stages of NTG (25 mild, 31 moderate, and 27 severe) and 90 healthy eyes were enrolled. The perfusion density (PD) and flux index (FI) of the optic nerve head divided into four sectors were determined. We compared the vascular, structural, and functional parameters between normal and glaucomatous eyes and performed a subgroup analysis among the NTG stages. Pearson correlation coefficient was used to assess the topographic correlation between vascular parameters and RNFL thickness. Results: PD and FI were significantly decreased in the NTG group. Subgroup analysis revealed a significant decrease in vascular parameters in most regions in the NTG group, except for the nasal PD and temporal FI. Post hoc analysis showed a significant decrease in PD in the inferior region across all severity levels (mild vs. moderate, p = 0.012; moderate vs. severe, p = 0.012; mild vs. severe, p < 0.001). PD and FI were strongly correlated with RNFL thickness in all quadrants (all p < 0.001), with the strongest correlation observed in the inferior region. Conclusions Vascular parameters were significantly decreased in glaucomatous eyes, and the degree of decrease in vascular parameters was proportional to glaucoma severity. Peripapillary perfusion analysis using optical coherence tomography angiography may complement other measurements used for glaucoma diagnosis.

The purpose of this study was to investigate the Korea-resident foreigners's adaptability and preference to Korean foods. The survey was carried out among 144 foreigners living in Seoul, Korea (male 57, female 87; from the East 109, from the West 35). Based on the first impression of Korean food, 'spicy', 'strong taste of seasoning', 'salty' were most common. About 90 percent of the foreigners adapted to Korean food in six months. It took more time to adapt to Korean food for Western people, compared to people from the East. Factors that influenced their adaption to Korean food were shown to be 'efforts by myself' and 'from friends'. Foreigners posited positive attitude toward Korean food according to their answers like 'nutritionally great food' and 'food with interesting ways of eating'. Westerners appeared to be more satisfied with Korean food. 'Too strong seasoning taste' and 'too sweet' were pointed out for further improvements. Beef Bulgogi, (Korean) fruit, Beef Ribs, Pork Ribs, and Grilled Pork Belly in order were foreigners' favorite foods, but Soju, Korean Sausage, Sliced Rice Cake Soup, Radish Kimchi and Vegetable Side Dishes were not. Taken together, the adaptability and preference to Korean foods to foreigners were different according to the gender and cultural background. Target marketing strategy of Korean Foods should be considered for foreign customers.
Emigrants and Immigrants ; Female ; Food Preferences ; Fruit ; Humans ; Korea ; Marketing ; Raphanus ; Ribs ; Seasons ; Vegetables