No abstract available.

122 cases of the genitourinary tract tumors admitted to the Department of Urology, National Medical Center, during the period, Aug. 1968 to July 1975 and the followings are the results. 1. 122-cases(12.8%) were tumor patient among 954 (male 702, female 252) Total admitted patients during 7 years. 2. Age distribution was from 5 months to 83 years showing the highest incidence in the 7th decade (30.3%) and cases over 41 years of age were 99(81.1%) 3. Sex ratio of male and female was 5.4:1(103:19) 4. In 122 cases, 42 cases{34.4%) were benign, 77 cases(63. 1%) were malignant and remainders were uncertain pathologically. 5. Among 122 cases, 57 cases(46.7%) were vesical, 35 cases(28.7%) prostatic, 19 cases(15.6%) renal, 5 cases(4.1%) penile. 3 cases(2.5%) testicular and 3 cases(2.5%) were urethral tumors. 6. Operations were performed in 114 patients (93.5%).
Age Distribution ; Female ; Humans ; Incidence ; Male ; Sex Ratio ; Urology

A 56 year-old female presented with dysphagia 8 weeks ago and newly developed dysphonia 2 weeks ago. The radiology study and swallowing difficulty evaluation study revealed the esophagus and the posterior wall of the laryngopharynx to be severely compressed by the mass of the anterior 4th and 5th vertebral body of cervical spine. En bloc excisional biopsy of the bony mass was performed, which completely resolved the clinical symptoms. We report a rare case of osteochondroma occurring at the anterior portion of cervical spine leading to dysphasia and dysphonia with a review of relevant literature.
Aphasia ; Biopsy ; Deglutition ; Deglutition Disorders ; Dysphonia ; Esophagus ; Female ; Humans ; Hypopharynx ; Osteochondroma ; Spine

BACKGROUND: Desmosomes are adhesive intercellular junctions that form an important component of the junction complexes of epithelial cells. They provide intercellular links between the intermediate filament cytoskeletons of adjacent cells and are thus involved in maintaining the structural integrity of tissues. OBJECTIVE: Calcium and retinoids are major regulators of epidermal differentiation and their role on keratin proteins are well known. However, their effects on desmosome moleucles are unknown. To address this question we initiated a study of the effects of these epidermal differentiation regulators on desmosomal components, i.e., desmoplakin, desmoglein, and pemphigus antigens. METHODS: We used monoclonal antibodies against desmoplakin(DP) and desmoglein(DG), and sera from patients with pemphigus vulgaris(PV), pemphigus foliaceus(PF) and paraneoplastic pemphigus (PNP) to study the effects of calcium and retinoic acids, which are major regulators of epidermal differentation, on desmosomal protein formation in human cultured deratinocytes. We performed immunofluorescence, immunoblotting and immunoprecipitation study using human keratinocytes cultured in high calcium media with or without retinoic acid and in low calcium media with or without retinoic acid. RESULTS: 1. In low calcium (0.15mM) media, PV antigen and DG were produced in a small amount and it appeared that these desmosomal proteins were located in cytosol. Whereas in high calcium (1.8mM) media, production of these desmosomal proteins was increased not they were assembled at the desmosomal structures located in cell-cell contact margins. 2. PF antigen, which was identical to the DG, were not produced or expressed in cultured keratinocytes even when cultured in high calcium media. 3. PNP antigen and DP were produced in cultured keratinocytes grown in both high low calcium media but their production was increased in high calcium media and only in high calcium media they were assembled at the desmosomal structures. 4. Retinoic acids induced loosening of cell-cell contacts of cultured keratinocytes and decreased the production of desmosomal proteins. CONCLUSION: Our results suggests calcium is a major regulator of the production and assembly of desmosomal proteins including pemphigus antigens, but PF sera and monoclonal antibodies against DG show different antigen binding characteristics. It appears that retinoic acids inhibit production of desmosomal proteins.
Adhesives ; Antibodies, Monoclonal ; Calcium* ; Cytoskeleton ; Cytosol ; Desmogleins ; Desmoplakins ; Desmosomes* ; Epithelial Cells ; Fluorescent Antibody Technique ; Humans ; Immunoblotting ; Immunoprecipitation ; Intercellular Junctions ; Intermediate Filaments ; Keratinocytes ; Pemphigus ; Retinoids ; Tretinoin*

This study was performed to find out the relationship between DNA pattern by flow cytometry and the prognosis of cervical squamous cell carcinoma, The subjects were 71 patients who were admitted to Catholic University Medical College Kangnam St. Marys Hospital from September 1983 to May 1989 under the diagnosis of cervical squamous cell carainoma. Samples were obtained from the subjects before chemotherapy or radiation therapy, and a through follow up stduy was carried out an the subjects. The authors obserued the relations between flow cytometric DNA pattern and clinical stage, age of patients, histopathological findings and tumor markers, with the following results. 1. The S-phase of the cell cycle increased significantly in Stages I, ll and III-IV compared to that of Stage O.However, there was no difference between Stages in G0/G1 phase and G2/M phase. 2. The incidence of aneuploid tumor increased significantly according to stage with the rates of increase reaching 22, 22%, 31.57%, 44.44% and 68.75% respectively in Stages 0, I, II, and Ill-lV. 3. The incidence of aneuploid tumor increased significantly depending on the age of patients with the rates standing at 21.42%, 31.58%, 40.90% and 68.75% respectively in the groups of below 40, 41-50, 51-60, and 61 years and over. 4. As for the relation between histopathological findings and the incidenee of aneuploid tumor, no difference was found according to the degree of differentiation, but there were significant differences between the keratinization group(23.07%) and the non keratinization group(51.11%).
Aneuploidy ; Carcinoma, Squamous Cell* ; Cell Cycle ; Cervix Uteri* ; Diagnosis ; DNA* ; Drug Therapy ; Female ; Flow Cytometry ; Follow-Up Studies ; Humans ; Incidence ; Prognosis* ; Biomarkers, Tumor

No abstract available.
Calcium* ; Humans ; Infant, Newborn* ; Metabolism*

No abstract available.
Oncogenes*

No abstract available.
Corrosion* ; Metals*

We report a case of a photosensitivity reaction in a 76-year-old inale induced by chlorpropamide ingestion. The patient had erythematous scaly patches on the sur. -exposed areas, A phototest revealed the decreased minimal erythemal dose(MED) to UVA(5J/cm). A photopatch test and photo-scartch test with 1% chlorpropamide ointment and 0.1% chlorpropamic!e .olution were all negative. An oral provocation test was performed, which showed a positive result with marked decrease of MED to UVA (5J/cm). After the cessation of chlorpropamide, his skin lesions were improved markedly with complete loss of photosensitivity. Macular hypopigmentations (leukcme.anoderma) appeared on the previous erythematous patchy ereas, but disappeared during the follow-up period.
Aged ; Chlorpropamide ; Eating ; Follow-Up Studies ; Humans ; Skin

The physical conditions of the Korean and the Japanese young adults (aged 18-29) were analyzed for the 10 important body dimensions such as stature, body weight, sitting height, chest circumference, and etc.. The Korean data published in 1979 and 1992 were compared with the Japanese data published in 1984 and 1994, respectively. Also, the physical developments and the sex differences of the Korean in past 13 years were compared with those of Japanese. The results are as follows. 1) The stature, sitting height and perineum height of the Korean young male and female are significantly smaller than those of the Japanese. 2) In the past, the chest circumference, waist circumference, hip circumference, body weight of the Korean are larger values than those of the Japanese. But, there are no significant differences in recent surveys. 3) Most body dimensions of male show significantly larger than those of female in the two countries. 4) There is no significant difference in thigh circumference between the Korean male and female in 1992. 5) There are no significant differences in thigh circumference between the '84 Japanese male and female and in hip circumference between the '94 Japanese male and female. 6) Compared with the results of the past surveys, the relative body weight, perineum height, and chest circumference of female to male are decreased in the two countries. But, the relative hip circumference of female to male are increased in both countries.
Asian Continental Ancestry Group* ; Body Weight ; Female ; Hip ; Humans ; Male ; Perineum ; Sex Characteristics ; Thigh ; Thorax ; Waist Circumference ; Young Adult