The increased susceptibility in patients of chronic renal failure to infection has been reported to be attributed to defects in granulocyte and lymphocyte function and proliferative activity of hematopoietic cells. The definite cause of the frequent infection in uremic patients, however, is still controversial. The effect of uremic plasma on the aspect of the hematopoietic cells has been scarcely been studied. In the present study, mouse bone marrow was cultured with uremic plasma, to evaluate the effect of uremic plasma on the proliferative activity and morphological features of CFU-GM. The results obtained were as follows. 1) The number of colonies in group co-cultured with uremic plasma was more reduced than that of normal plasma group. 2) There was no difference between the group cultured with predialytic uremic plasma and that of postdialytic plasma in number of colonies, macroclusters and microclusters. 3) The forms of colony were granulocytic and monocytic forms at 5 day of culture. Electron microscopically, granulocytes disclosed electron dense azurophilic granules and electrolucent specific granules in the cytoplasm, and monocyte showed numerous vesicles and vacuoles in the cytoplasm which had finger-like projections. 4) The molecular weight of inhibitory factor in the uremic plasma was supposed to be less than 50,000 daltons.
Mice ; Animals

No abstract available.
Rheumatic Diseases*

No abstract available.
Rheumatic Diseases*

BACKGROUND: The main therapeutic method currently used for the treatment of vitiligo vulgaris is either photochemotherapy or corticosteroids. But both of the procedures however require lengthy treatment to obtain a satisfactory result. OBJECTIVE: To determine the increased efficacy of the combination therapy of photochemotherapy with corticosteroid and chlorpromazine compared with the usual monotherapy. METHODS: The combination therapy was done in 29 cases and the results were compared with the results of either monotherapy appearing in the literatures. RESULTS: f the 29 patients, 14(48.3%) patients achieved 100% repigmentation, 7(24.1%) patients 75~50%, 5(17.2%) patients 25~50%, and 3(10.4%) patients less than 25%. For the cured patients, 190.3 days and 32.7 times of photochemotherapy were used. CONCLUSION: The combination therapy is more effective, and the duration of treatment can be greatly reduced compared with either monotherapy.
Adrenal Cortex Hormones ; Chlorpromazine ; Humans ; Methods ; Photochemotherapy ; Vitiligo*

No Abstract Available.
Knee* ; Synovitis, Pigmented Villonodular*

The experiment was designed to investigate type-selectivity of the involved muscle fibers and changes in the component ratios of the fiber types following the progression of disuse atrophy in the skeletal muscle. After inducing disuse atrophy of the skeletal muscle by applying cast on the hind limb, we used histological and histochemical stains in the sections of the rat Tibialia anterior muscles. The results were as follows. 1. Even 8 weeks after immobilization of the hind limb, differentiation of muscle fiber types by histolo gical and histochemical staining methods in the Tibialis anterior muscle could be possible. 2. Atrophy of muscle fibers was more pronounced in type IIB and type I fibers than in type IIA fibers. 3. Central migration of sarcolemmal nuclei and ring fiber appeared after 6th and 8th weeks of immobilization respectively, in the H&E and trichrome preparations. Ac-pase or Alk-pase positive fibem were not noted throughout the experimental periods.
Animals ; Atrophy ; Coloring Agents ; Extremities ; Immobilization ; Muscle, Skeletal ; Muscles ; Muscular Disorders, Atrophic ; Rats

No abstract available.
Hydralazine*

Isolated situs in versus of the stomach with otherwise normal position of the thoracic and abdominal vescera isan extremely rare anomaly occurring in two distinct forms. Majority of cases are associated with eventration of the diaphragm and are reported as being confused with spontaneous pneumothorax of pyopneumothorax at base of the right lung. The right sided stomach may produce interesting and confusing changes in liver scan. We have experienced 2 cases of the isolated dextrogastria.
Diaphragm ; Liver ; Lung ; Pneumothorax ; Stomach

Panniculitis, Lupus Erythematosus*

No abstract available.