We report a case of plexiform neurofibroma developed under the overlying speckled lentiginous nevus, which occurred in a 20 year-old man. In this patient and his family no other signs of von Recklinghausens disease were found. Discussion is focussed on the fact that both plexiform neurofibroma and speckled lentigmous nevus, which represent a defect in the neural crest, occurred in the same area of the skin.
Humans ; Neural Crest ; Neurofibroma, Plexiform* ; Neurofibromatosis 1 ; Nevus* ; Skin

No abstract available.
Oncogene Proteins* ; Oncogenes* ; Teratocarcinoma*

BACKGROUND: Bupivacaine is a potent, and commonly used, long acting local anesthetic. If accidentally injected into the systemic circulation, bupivacaine can cause lethal dysrhythmias and circulatory collapse. Attempts to treat bupivacaine induced cardiac toxicity have been varied and controversial, and they have not been very successful. The aim of this study was to investigate the electrophysiologic effects of bupivacaine in Purkinje fibers. METHODS: Effects of bupivacaine on the membrane potential were studied in 12 isolated canine Purkinje fibers. Purkinje fibers from ventricle were dissected and mounted in a tissue chamber perfused with Tyrode's solution. Transmembrane potentials recorded through glass microelectrodes filled with 3M KCI in the beating or quiescent Purkinje fibers during infusions of bupivacaine at concentratons of 3*10/-7M,10/-6M, 3*10/-6M,10/-5M, and 3*10/-5M. RESULTS: Bupivacaine reduced action potential druation in a dose-dependent manner. Bupivacaine produced a decrease in intracelullar sodium ion activity in driven(1Hz) and quiescent canine Purkinje fibers. Bupivacaine-induced hyperpolarizaton of diastolic membrane potential in quiescent Purkinje fibers was dose dependent, and the hyperpolarization by bupivacaine was attenuated by depolarization induced by high potassium extracellular concentration in part. CONCLUSIONS: These results suggest that bupivacaine decreases the fast inward sodium current, and inhibits pacemaker current in canine Purkinje fibers.
Action Potentials ; Bupivacaine* ; Glass ; Membrane Potentials* ; Membranes* ; Microelectrodes ; Potassium ; Purkinje Fibers ; Shock ; Sodium ; Sodium Channels

The diagnosis of a Battered Child Syndrome is made by the pediatrician, surgeon and the radiologist because almost parents deny the diagnosis or refuse to answer the doctor's questions. The imaging modalities play a key role in the investigation and documentation of the battered child syndrome, because of the high frequency of the typical skeletal lesion. Although physical abuse is denied by parents, the recognition of this entity is possible by the primary diagnostic imaging study in the suspected child abuse. The imaging studies are either a bone scan and x-ray series or a complete radiolographic skeletal survey by X-ray series. In an expected intracranial injury, a CT scan of the head is mandatory We experienced a case of Battered Child Syndrome in a 6 month-old male infant who had subdural hemorrhage and fractures of skull and ribs in different stages of healing and repair. The brief review of the literature was made.
Battered Child Syndrome* ; Child ; Child Abuse ; Diagnosis ; Diagnostic Imaging ; Head ; Hematoma, Subdural* ; Humans ; Infant ; Male ; Parents ; Ribs ; Skull ; Tomography, X-Ray Computed

We examined visual acuity and refractive state of 1,522 children (904 boys and 618 girls) in the 6th grade of the primary school in the center of Kwangju city, and of 1,318 children(711 boys and 607 girls) in the outskirts. To evaluate environmental factors, the statistical comparative study in two groups about visual acuity and refractive state including the data from the questionnaires answered by parentr was done. The results were as follows: 1. The incidence of subnormal visual acuity was 20.5%. It was higher in girls (25.9%) than in boys (16.3%), and higher in the school in the center (22.7%) of the city than in the outskirts (17.9%). Especially, in girls, it was significantly low in the outskirts (21.4%) comparing to the center (30.3%). 2. In the relationship between the incidence of subnormal visual acuity and posture, the incidence was higher in the children who have a poor carriage during studying(24.6%) than in the children who have a fine carriage (19.9%) and it was markedly higher in girls (30.7%) than in boys (19.7%). 3. The incidence of subnormal visual acuity was higher in the children who maintained inadequate distance from the TV set (24.1% ) than in the children who maintained adequate distance (19.6%), and it was higher in girls (31.3%) than in boys (17.8%). 4. The incidence of subnormal visual acuity was similar in the children who had balanced diet (21.6%)and the children who had one-sided diet (22.8%). 5. Refractive state of the eyes with subnormal visual acuity was myopic in 17.0%, hyperopic in 3.0% and mixed astigmatic in 0.3%. The incidence of myopic eyes was higher in girls (21.3%) than in boys (13.8%). 6. Occurrence of the eyes which returned from abnormal refractive state to emme tropia by instillation of 5% homatropine solution was similar in boys (5.2%) and girls (6.9%) and the eyes were considered to be pseudomyopic.
Child* ; Diet ; Female ; Gwangju ; Humans ; Incidence ; Posture ; Surveys and Questionnaires ; Visual Acuity*

A new atypical antipsychotics, risperidone has been shown to be an effective drug in the treatment of schizophrenia and other psychotic disorders. We present a case report of successful treatment in a psychotic patient with complex partial seizure. A case history, of 26-year-old women in whom psychotic symptoms due to temporal lobe epilepsy was successfully treated with risperidone and anticonvulsants, is presented. A prospective clinical trial of risperidone with a randomized controlled design in patients with epileptic psychosis is warranted.
Adult ; Anticonvulsants ; Antipsychotic Agents ; Epilepsy, Temporal Lobe ; Female ; Humans ; Psychotic Disorders* ; Risperidone* ; Schizophrenia ; Seizures*

No abstract available.
Fistula ; Neck* ; Salivary Glands*

A case of Aicardi syndrome with cleft lip and palate was experienced at the Department of Pediatrics, College of Medicine, Hallym University, and the patient's infantile spasm was treated with ACTH. In previous studies, four cases of Aicardi syndrome accompanied by cleft lip and palate were reported. We present the fifth case of Aicardi syndrome with cleft lip and palate in the world. Thus, facial clefts may be found as an occasional manifestation of Aicardi syndrome.
Adrenocorticotropic Hormone ; Aicardi Syndrome* ; Cleft Lip* ; Infant ; Infant, Newborn ; Palate* ; Pediatrics ; Spasms, Infantile

Appendiceal diverticula are uncommon lesions. A retrospective study of appendiceal diverticula was done for 1379 appendectomies is performed from June 1991 to May 1996. Thirty-six cases (2.6%) of appendiceal diverticula were found. Only one case was detected operatively; the rest of them were diagnosed pathologically. These thirty-six cases have been classified into three groups: 23 cases of primary appendiceal diverticulitis, 8 of secondary appendiceal diverticulitis, and 5 of simple diverticulosis. The clinical manifestations of primary appendiceal diverticulitis were different from those of typical acute appendicitis. Primary appendiceal diverticulitis was seen mainly after the fourth decade of life. The pain came on rather insidiously and seemed to extend over a longer period. A history of previous attack was frequent. The rate of perforation in primary appendiceal diverticulitis was 78.2%.The false form of appendiceal diverticula was more common in most series. Also, no case was detected in appendectomies performed on many patients under 10 years of age with a diagnosis of appendicitis. They seemed to develop after birth and were seen frequently along the mesenteric border. The rate of mucosal hyperplasia in appendiceal diverticula was 61.1%, higher than that for appendicitis. Vascular hiatus between muscular bundles along the mesenteric side, and the mesenteric covering over the diverticula, as well as the inability of false diverticula to endure high intraluminal pressures, seem to be pathophysiologically associated with the cause and the high perforation rate in appendiceal diverticula. The clinical picture and the pathologic findings of primary appendiceal diverticulitis are definitely different from those of acute appendicitis. We suggest primary appendiceal diverticulitis be regarded as a clinical entity, not a variant of acute appendicitis. The patient with atypical right lower quadrant pain should be examined with this diagnosis in mind.
Appendectomy ; Appendicitis ; Diagnosis ; Diverticulitis* ; Diverticulum ; Humans ; Hyperplasia ; Parturition ; Retrospective Studies

No abstract available.
Neurocutaneous Syndromes*