PURPOSE: To evaluate the CT findings of focal organizing pneumonia and to correlate them with pathologic findings to help differentiating from lung cancer. MATERIALS AND METHODS: We evaluated radiologic and pathologic findings of five patients with solitary pulmonary nodule which were confirmed as focal organizing pneumonia pathologically. RESULTS: On CT scan, focal organizing pneumonia had irregular margin contacting the pleura in all five cases. The shape of the nodules were spherical to wedge or elliptical and the size from 3.5cm to 5.5cm (average 4.2cm) in largest diameter. On postcontrast CT scan, all nodules showed enhancement and four cases showed central low density components. Two nodules contained air within the nodule. In four cases, pleural changes such as effusion and/or focal thickening were noted. No lymphadenopathy was found in all cases. Pathologically, the enhancing portion on CT showed findings of organizing pneumonia such as granulation tissue with fibroblast proliferation in alveolar space and interstitial thickening. The central low density areas on CT were due to ischemic necrosis, abscess and exudate, transudate and infiltration of foamy histiocyte. CONCLUSION: The possibility of focal organizing pneumonia should be considered when peripherally located solitary pulmonary nodule had enhancing component with no combined lymphadenopathy on CT scan.
Abscess ; Exudates and Transudates ; Fibroblasts ; Granulation Tissue ; Histiocytes ; Humans ; Lung Neoplasms ; Lymphatic Diseases ; Necrosis ; Pleura ; Pneumonia* ; Solitary Pulmonary Nodule ; Tomography, X-Ray Computed

No abstract available.
Female ; Pregnancy ; Pregnancy, Ectopic*

No abstract available.
Aneurysm ; Aneurysm, Ruptured* ; Cerebral Veins* ; Veins*

We observed clinically 27 cases of MCLS at this pediatric department from Jan. 1980 to Jun. 1984 and following result were obtained. 1) The peak incidence of these cases was from 1 year to 4 year of age(74%) and male children were affected more frequently than female children at a ratio of 2.4:1. 2) Clinical manifestation of MCLS were high fever, conjunctioval injection, changes of oral cavity and lips, erythematous rash, cervical lymphadenopathy, changes of the extremities. 3) The abnormal laboratory findings include leukocytosis, slight anemia, raised ESR, positive CRP, mild proteinuria or pyeuria, and slight increase of serum transaminase and LDH. 4) The abnormal cardiovascular findings were as follow : heart murmur in 15% cardiomegaly in 19% by chest roentgenogram, electrocardiographic abnormalities in 59%, suspicious aneurysmal dilatation and coronary aneurysm by 2-D echocardiogram in 11%. 5) Aspirin was given in acute febrile stage as antiinflammatory dose(100mg/kg/day), in non-febrile convalescent stage to maintain low dose of aspirin(20-30mg/kg/day) as antiplatelet effect, and completely recovered in all cases without andy complication.
Anemia ; Aneurysm ; Aspirin ; Cardiomegaly ; Child ; Coronary Aneurysm ; Dilatation ; Electrocardiography ; Exanthema ; Extremities ; Female ; Fever ; Heart Murmurs ; Humans ; Incidence ; Leukocytosis ; Lip ; Lymphatic Diseases ; Male ; Mouth ; Mucocutaneous Lymph Node Syndrome* ; Proteinuria ; Thorax

The leiomyoma of the vagina is relatively rare benign solid tumor, and majority of them were not recognized until after operation. Variable opinion exists as to the exact origin of this lesion. The most frequent location is the anterior vaginal wall. Recently we experienced a case of vaginal leiomyoma arising in the anterior vaginal wall and now we present it with a brief review of the literatures.
Leiomyoma* ; Vagina*

BACKGROUND: Recently, the molecular pathologic investigation for clonality in lymphomas has been introduced and has gained a role in the diagnosis of lymphomas. In fact, the clonality test using TCRGR phenomenon has been done by Southern blot analysis (SBA) and polymerase chain reaction (PCR) for molecular pathologic diagnosis of T cell lymphomas. However, it is difficult to perform SBA with paraffin embedded specimens or with samples of small skin biopsies. OBJECTIVE: We investigated the efficacy of PCR amplification of TCR gene in paraffin em-bedded cutaneous T cell lymphomas. METHODS: Iii this study, the clonality was assessed by polymerase chain reaction (PCR) analysis of T cell receptor gamma (TCR) gene from the DNA extracts obtained from paraffin em-bedded tissues (PET) of malignant T cells, B cell lymphomas, and benign cutaneous T cell proliferative disorders. Heteroduple-x-analyses were also performed to rule out the false positives. RESULTS: Among the total of 62 cases analyzed, monoclonality was observed in 4 out of 10 mycosis fungoides, 7 out of 9 cutaneous T cell lymphomas excluding mycosis fungoides, 1 out of 3 angiocentric lymphomas, 2 out of 2 lymphomatosis papulosis, 1 out of 7 large plaque parapsoriasis, and 1 out of 2 T cell lymphomas in other organs. No monoclonality was observed in 9 inflammatory cutaneous diseases, 5 small plaque parapsoriasis, 4 cutaneous B cell lymphomas, and 11 B cell lymphomas in lymph nodes. CONCLUSION: The results suggest that the PCR method and heteroduplex analysis used in this study were not only practical but also efficacious for the diagnosis of cutaneous T cell lymphomas using tissues embedded in paraffins.
Biopsy ; Blotting, Southern ; Diagnosis ; DNA ; Gene Rearrangement* ; Genes, T-Cell Receptor ; Heteroduplex Analysis* ; Lymph Nodes ; Lymphoma ; Lymphoma, B-Cell ; Lymphoma, T-Cell ; Lymphoma, T-Cell, Cutaneous ; Mycosis Fungoides ; Paraffin ; Parapsoriasis ; Polymerase Chain Reaction* ; Receptors, Antigen, T-Cell* ; Skin ; T-Lymphocytes

No abstract available.

The unilateral megalencephaly is a rare brain malformation characterized by cerebral asymmetry and cortical dysplasia caused by faulty migration of the subependymal neuroblasts. We experienced a case of unilateral megalencephaly in a two day-old male with the chief complaint of asymmetric head appearance. Large left hemisphere with agyria, pachygyria, dilatation of lateral ventricle, and the thick cortex of the ipsilateral hemisphere were showed in brain MRL, Clinical findings in this case were intractable seizure, hemiparesis, and psychomotor retardation. A review of literatures was also presented briefly.
Brain ; Dilatation ; Head ; Humans ; Lateral Ventricles ; Lissencephaly ; Male ; Malformations of Cortical Development ; Paresis ; Seizures

No abstract available.
Hernia*

Focal cerebral ischemia was made in 20 adult cats by transorbital middle cerebral artery occlusion (MCAO) under pentobarbital anesthesia. Arterial blood gas, systemic arterial blood pressure (SABP), intracranial pressure (ICP), and regional cerebral blood flow (rCBF) on ectosylvian, suprasylvian, and marginal gyrus of the left hemisphere by hydrogen clearance were measured for 30 minutes before and 120 minutes after middle cerebral artery occlusion. Ten animals were treated with 20 mg/kg of pentoxifylline (PTF) and ten animals with 1ml/kg of normal saline as the control group for 30 minutes before and 30 minutes after middle cerebral artery occlusion. There was no beneficial effect of pentoxifylline (Trental(R)) on basal blood flow over left hemisphere before middle cerebral artery occlusion. Regional cerebral blood flow was highly significantly improved on the marginal gyrus (MG) for 90 minutes after middle cerebral artery occlusion, more remarkable for initial 60 minutes (P<0.01), and also significantly restored on suprasylvian gyrus (SSG) for initial 60 minutes by pentoxifylline (P<0.05). However, pentoxifylline failed to improve regional cerebral flow on extosylvian gyrus (ESG) which was considered dense core of infarct area due to middle cerebral artery occlusion in cat. In addition, pentoxifylline had significant hypotensive effect during intravenous administration for 60 minutes (P<0.05). These findings suggest the possibility of pentoxifylline to ameliorate hemorheological property rather than vasodilating effect in the collaterally perfused area around dense infarct.
Administration, Intravenous ; Adult ; Anesthesia ; Animals ; Arterial Pressure ; Brain Ischemia ; Cats ; Cerebral Infarction* ; Hemorheology ; Humans ; Hydrogen ; Infarction, Middle Cerebral Artery ; Intracranial Pressure ; Pentobarbital ; Pentoxifylline*