2.DNA Patterns by Flow Cytometric Analysis of Squamous Carcinoma Cells of the Cervix Uteri : Relations with Prognosis and Biochemical Characteristics.
Korean Journal of Gynecologic Oncology and Colposcopy 1990;1(1):80-89
This study was performed to find out the relationship between DNA pattern by flow cytometry and the prognosis of cervical squamous cell carcinoma, The subjects were 71 patients who were admitted to Catholic University Medical College Kangnam St. Marys Hospital from September 1983 to May 1989 under the diagnosis of cervical squamous cell carainoma. Samples were obtained from the subjects before chemotherapy or radiation therapy, and a through follow up stduy was carried out an the subjects. The authors obserued the relations between flow cytometric DNA pattern and clinical stage, age of patients, histopathological findings and tumor markers, with the following results. 1. The S-phase of the cell cycle increased significantly in Stages I, ll and III-IV compared to that of Stage O.However, there was no difference between Stages in G0/G1 phase and G2/M phase. 2. The incidence of aneuploid tumor increased significantly according to stage with the rates of increase reaching 22, 22%, 31.57%, 44.44% and 68.75% respectively in Stages 0, I, II, and Ill-lV. 3. The incidence of aneuploid tumor increased significantly depending on the age of patients with the rates standing at 21.42%, 31.58%, 40.90% and 68.75% respectively in the groups of below 40, 41-50, 51-60, and 61 years and over. 4. As for the relation between histopathological findings and the incidenee of aneuploid tumor, no difference was found according to the degree of differentiation, but there were significant differences between the keratinization group(23.07%) and the non keratinization group(51.11%).
Aneuploidy
;
Carcinoma, Squamous Cell*
;
Cell Cycle
;
Cervix Uteri*
;
Diagnosis
;
DNA*
;
Drug Therapy
;
Female
;
Flow Cytometry
;
Follow-Up Studies
;
Humans
;
Incidence
;
Prognosis*
;
Biomarkers, Tumor
3.Reflux nephropathy in children.
Bon Sang KOO ; Joon Soo LEE ; Pyung Kil KIM
Korean Journal of Nephrology 1993;12(3):433-439
4.Clinical Significance of Transperineal Duplex Doppler Ultrasonography in the Diagnosis of Arteriogenic Impotence.
Gun Pyung KIM ; Kwang Sung PARK ; Soo Bang RYU
Korean Journal of Urology 2000;41(11):1384-1388
No abstract available.
Diagnosis*
;
Female
;
Impotence, Vasculogenic*
;
Male
;
Ultrasonography, Doppler, Duplex*
5.The effects of adriamycin on twitch force and membrane potential in an isolated Guinea-pig papillary muscle.
Chan Uhng JOO ; Pyung Han HWANG ; Jung Soo KIM ; Hee Cheol YU ; Soo Wan CHAE
Journal of the Korean Pediatric Society 1991;34(5):677-681
No abstract available.
Doxorubicin*
;
Membrane Potentials*
;
Membranes*
;
Papillary Muscles*
6.Cyclosporin A in the child minimal change nephrotic syndrome.
Pyung Kil KIM ; Soo Kyung YUN ; Ki Soo PAI ; Ja HOon KOO ; Cheul Woo KOH
Korean Journal of Nephrology 1993;12(4):549-556
No abstract available.
Child*
;
Cyclosporine*
;
Humans
;
Nephrosis, Lipoid*
7.A Case of Primary Malignant Mixed Mullerian Tumor of the Pelvic Peritoneum.
Soo Pyung KIM ; Jeong Ja KIM ; Eun CHOI ; Seung Hae RO ; Jang Heub KIM ; An Hee LEE
Korean Journal of Obstetrics and Gynecology 1999;42(1):145-148
Malignant mixed miillerian tumor (MMMT) was one of the rare uterine sarcoma. This tumor is composed of sarcoma and carcinoma. Primary MMMT in the peritoneum is among the rarest sites for MMMT. MMMT is highly malignant and the prognosis is grave due to frequent recurrence and metastasis. In the world literature, only 22 cases with primary MMMT of the peritoneum have been reported and most of these were single report. We report one case of primary MMMT in the peritoneum with a brief review.
Neoplasm Metastasis
;
Peritoneum*
;
Prognosis
;
Recurrence
;
Sarcoma
8.A case of dermatomyositis remitted with cyclosporin A.
Jo Won JUNG ; Ki Soo PAI ; Pyung Kil KIM ; Woo Hee JUNG
Journal of the Korean Pediatric Society 1992;35(3):399-405
No abstract available.
Cyclosporine*
;
Dermatomyositis*
9.Analysis of Platelet Membrane Glycoprotein Iib-IIIa Complex in Whole Blood of Glanzmann's Thrombasthenia by Flow Cytometry.
Byoung Geun LEE ; Man Choon KANG ; Jong Man PARK ; Pyung Han HWANG ; Jung Soo KIM
Journal of the Korean Pediatric Society 1994;37(11):1540-1547
Glanzmann's thrombasthenia is a rare autosomal recessive hemorrhagic disorder characterized by prolonged bleeding time, ad deficient or absent clot retraction in the presence of normal platelet count. The major underlying abnormality in this disease is grossly defective first-phase aggregation of platelet, which are unresponsive to ADP or other platelet agonists such as epinephrine, collagen, thrombin in any concentration. This disability is caused by a decrease or absence of the platelet membrans glycoprotein IIb-IIIa complex, a member of the integrin family of adhesive receptors involved in cell-cell and cell-matrix fibronectin, and vitronectin On the development of surface labeling technique, a variety of biochemical techniques such as radioimmunoassay, crossed immunoelectrophoresis and SDS-PAGE have been used to study the structure and the function of platelet membrane glycoproteins, and to detect the platelet functional defect. But all of these techniques demand a relatively large amount of homogeneous paletelet population that requires manipulation through isolation and washing procedures before analysis. In order to eliminaste such an intricate procedure, we have applied method for analyzing platelet surface components in whole blood using monoclonal antibody and flow cytometry to recognize the absence of severe reduction of platelet membrane glycoprotien llb-llla complex. Platelet analysis by flow cytometry is a successful alternative rapid diagnostic technique for Glanzmann's thrombasthenia patients as well as well as for carriers of this disease. Fow cytometry technique provides a sensitive tool for investigating platelet functional defects caused by altered expression or deficiency of platelet surface proteins.
Adenosine Diphosphate
;
Adhesives
;
Bleeding Time
;
Blood Platelets*
;
Clot Retraction
;
Collagen
;
Electrophoresis, Polyacrylamide Gel
;
Epinephrine
;
Fibronectins
;
Flow Cytometry*
;
Glycoproteins
;
Hemorrhagic Disorders
;
Humans
;
Immunoelectrophoresis, Two-Dimensional
;
Membrane Glycoproteins*
;
Membrane Proteins
;
Membranes*
;
Platelet Count
;
Platelet Membrane Glycoproteins
;
Radioimmunoassay
;
Thrombasthenia*
;
Thrombin
;
Vitronectin
10.Natural killer cell activity and antibody dependent cell-mediated cytotoxicity in children with minimal change nephrotic syndrome.
Pyung Kil KIM ; Ki Soo PAI ; Jung Koo YOUN ; In Hong CHOI
Korean Journal of Nephrology 1992;11(4):370-376
No abstract available.
Child*
;
Humans
;
Killer Cells, Natural*
;
Nephrosis, Lipoid*