1.A computer program for survival analysis.
Journal of the Korean Cancer Association 1991;23(2):429-435
No abstract available.
Survival Analysis*
2.Flow Cytometric Analysis of DNA Content in Cervical Neoplasia Patients Infected with Human Papillomavirus Types 16 and 18.
Tchan Kyu PARK ; Soo Nyung KIM
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(4):47-55
To investigate the role of human pepillomavirus(HPV) infection on DNA content of cervical cancers, thirty-seven cases af ceryical squamous carcinoma were studied with the method of flow cytometry for deoxyribonucleic acid(DMA) content and Southern blot hybridizalion for typing of HPV type 1.6 or type 18 DWA in cornbination with other elinical pnrameters. There were 18 dipleid cases(48.6%) and 19 aneuploid(51.4%). The mean age of the patients with diplaid and aneuploid tumars was 51.6 years and 53.6 years, respectively, No significant age difference was found between diploid and aneuploid groups. Six of 13(46.2%) carcinnma in eiiu and 13 of 24(54.2%) invasive cervical carcinoma were aneuploid, and t,he proportinn of aneuploid tumors was not significantly different between the two groups. Six of 10 tumors(60.0%) in stage I, 5 of 11 tumors(45.5%) in stage II, 2 of 3 tumors(66.7%) in stage III were aneuploid. The frequency was not significantly different according to the clinical stage, Aneuploidy was present in 50.0% of HPV 16 positive lesion, 66.7% of HPV 18 positive lesion, and 41.7% of HPV 16 and 18 negative lesion. There was no statistically difference in the incidenee of aneuploidy when all HPV lesions were compared. Of 25 patients with HFV 16 or l8 positive lesion, aneuploidy was demonstrated in the specimen of four of eight patients with careinoma in situ and nine of 17 with invasive cervical carcinoma. In suromary, we found thst the ineidere of DNA aneuploidy was somewhat higher when HPV 18 positive lesion was compared to HPV 16 and 18 negative lesion but the difference was not statistically significant.
Aneuploidy
;
Blotting, Southern
;
Carcinoma, Squamous Cell
;
Diploidy
;
DNA*
;
Flow Cytometry
;
Human papillomavirus 16
;
Human papillomavirus 18
;
Humans
;
Humans*
3.Prognostic Significance of Human Papillomavirus Types 16 and 18 in Invasive Cervical Cancer.
Soo Nyung KIM ; Tchan Kyu PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1994;5(1):1-8
Thirty-nine cases of invasive cervical cancer with human papillomavirus(HPV) DNA sequences were analyzed to detennine if HPV type 16 or 18 clinical or prognostic significance. HPV type was determined by Southern blotl hybridization. HPV 16 was detected in 12 cases, and HPV 18 in 5 cases. Sixty percent of HPV 18 tumors were grade III (3 of 5), whereas 8.3% (1 of 12) of HPV 16 tumors and 5.6% (1 of 18) of HPV 16/18 negative tumors were grade III. Age, clinieal stage, histologic cell type, lesion size, and liyrriph node metestasis in relation to HPV type were not statistically significant. The mean age of HPV 1~6 group was 50 years, compared to 47 years for the HPV 18 group. Of 30 squamous carcinomas, HPV 16 was detected in 12 cases(40.0%), and HPV 18 in 4 cases (13.3%). Of 4 adenosquamous and adenocarcinomas, HPV 16 was detected in 0 case(0.0%), and HPV 18 in 1 case(25.0%). Among stge IB-IIA caners, lymph node metastasis was associated with 20% of HP-V 16 cases(2 of 10) as cotinparxl with 25% of HPV 18 cases(1 of 4) and 7.7% Of HPV 16/18 negative cases (1 of 13). It is suggested that HPV type 18 might be associated with worse prognostic factos of invasive cervical cancer than HPV type 16.
Adenocarcinoma
;
Base Sequence
;
Carcinoma, Squamous Cell
;
Human papillomavirus 16
;
Human papillomavirus 18
;
Humans*
;
Lymph Nodes
;
Neoplasm Metastasis
;
Uterine Cervical Neoplasms*
4.Tumor-associated trypsin inhibitor(TATI) in gynecologic tumors.
Soo Nyung KIM ; In Jae CHO ; Doo Ho KIM
Journal of the Korean Cancer Association 1991;23(3):554-562
No abstract available.
Trypsin*
5.A case of clear cell carcinoma of the ovary associated with endometriosis and uterine myoma.
Soo Nyung KIM ; Bum Chae CHOI ; Doo Ho KIM
Korean Journal of Obstetrics and Gynecology 1991;34(3):450-454
No abstract available.
Endometriosis*
;
Female
;
Leiomyoma*
;
Ovary*
7.Obstetrical ultrasound data-base management system by using personal computer.
Hae Jeong JEON ; Jeong Hee PARK ; Soo Nyung KIM
Journal of the Korean Radiological Society 1993;29(2):326-331
A computer progrem which performs obstetric calculation on Clipper Language using the datas from ultrasonography was developed from personal computer. It was designed for fast assessment of fetal development, prediction of gestagional age, and weight from ultrasonographic measurements which included biparietal diameter, femur length, gestational sac, occipito-frontal diameter, abdominal diameter, and etc. The Obstetricel-Ultrasound data-Base Managemant System was tested for its performance. The Obstetrical-Ultrasound Data-Base Management System was very useful in patient management with its convenient data filing, easy retrieval of previous report, prompt but accurate estimation of fetal growth and skeletal anomaly and production of equation and growth curve for pregnant women.
Female
;
Femur
;
Fetal Development
;
Gestational Sac
;
Humans
;
Microcomputers*
;
Pregnant Women
;
Ultrasonography*
8.Interferon-alpha2a, 13-cis-retinoic Acid and Radiotherapy for Locally Advanced Squamous Carcinoma of the uterine Cervix: Preliminary Study.
Jung Pil LEE ; Tchan Kyu PARK ; Soo Nyung KIM
Korean Journal of Gynecologic Oncology and Colposcopy 1995;6(3):174-182
Locally advanced cancer of the uterine cervix is a major cause of death worldwide. Standard treatment with rdiolherepy for locally advanced cancer of the uterine cnvix has a response rate of less than 50%. Resently concurrent chcmoradirothcrpay has been introduced but with some contvovesy. Interferon and retinoic acid are inducible proteins which posses many hiologic activities such as, antiproliferative, immunomodulatory and antineoplastic properties. Combination of interferon and retinoic acid has produced high response rates especially for patients with squamous cell carcinoma . And they may potentiate the radiation cytotoxicity as adiosensitizer. This study was underaken to assess the clinical efficacy of combination regimen with interferon-alpha2a, 13-cis-retinoic acid and radiotherapy from Dec. 1988 to Dex. 1994 at Severance hospital Yonsei uniersity. Twenty seven patients of locally advanced squamous cell carcionma of the uterine cervix enrolled in this study are evaluated for response and toxicity. The results were as follow: 1. Preliminary results of interferon-alpha2a 13-cis-retinoic acid and radiotherapy are 46.7% of response rate(33.3% complete response)and those of concurrent chemoradiotherapy are 41.7% of response rate(46.7% complete response). 2. Major toxicity of interferon-alpha2a, 13-cis-retinoic acid and radiotherapy is fever(60.0%), and only case of grade 2 anemia and one case of grade 1 AST/ALT elevation was noted. There was no grade 3 or 4 toxicity. Systemic interferon-alpha2a, 13-cis-retinoc acid and radiotherapy is highly active, well tolerated therapy for locally advanced cervical cancer.
Anemia
;
Carcinoma, Squamous Cell*
;
Cause of Death
;
Cervix Uteri*
;
Chemoradiotherapy
;
Female
;
Humans
;
Interferons
;
Isotretinoin*
;
Radiotherapy*
;
Tretinoin
;
Uterine Cervical Neoplasms
9.Interferon-alpha2a, 13-cis-retinoic Acid and Radiotherapy for Locally Advanced Squamous Carcinoma of the uterine Cervix: Preliminary Study.
Jung Pil LEE ; Tchan Kyu PARK ; Soo Nyung KIM
Korean Journal of Gynecologic Oncology and Colposcopy 1995;6(3):174-182
Locally advanced cancer of the uterine cervix is a major cause of death worldwide. Standard treatment with rdiolherepy for locally advanced cancer of the uterine cnvix has a response rate of less than 50%. Resently concurrent chcmoradirothcrpay has been introduced but with some contvovesy. Interferon and retinoic acid are inducible proteins which posses many hiologic activities such as, antiproliferative, immunomodulatory and antineoplastic properties. Combination of interferon and retinoic acid has produced high response rates especially for patients with squamous cell carcinoma . And they may potentiate the radiation cytotoxicity as adiosensitizer. This study was underaken to assess the clinical efficacy of combination regimen with interferon-alpha2a, 13-cis-retinoic acid and radiotherapy from Dec. 1988 to Dex. 1994 at Severance hospital Yonsei uniersity. Twenty seven patients of locally advanced squamous cell carcionma of the uterine cervix enrolled in this study are evaluated for response and toxicity. The results were as follow: 1. Preliminary results of interferon-alpha2a 13-cis-retinoic acid and radiotherapy are 46.7% of response rate(33.3% complete response)and those of concurrent chemoradiotherapy are 41.7% of response rate(46.7% complete response). 2. Major toxicity of interferon-alpha2a, 13-cis-retinoic acid and radiotherapy is fever(60.0%), and only case of grade 2 anemia and one case of grade 1 AST/ALT elevation was noted. There was no grade 3 or 4 toxicity. Systemic interferon-alpha2a, 13-cis-retinoc acid and radiotherapy is highly active, well tolerated therapy for locally advanced cervical cancer.
Anemia
;
Carcinoma, Squamous Cell*
;
Cause of Death
;
Cervix Uteri*
;
Chemoradiotherapy
;
Female
;
Humans
;
Interferons
;
Isotretinoin*
;
Radiotherapy*
;
Tretinoin
;
Uterine Cervical Neoplasms
10.A case of systemic lupus erythematosus associated with pregnancy.
Keun Jai YOO ; Soo Nyung KIM ; In Jae CHO ; Doo Ho KIM ; Kyung Soo KIM
Korean Journal of Obstetrics and Gynecology 1993;36(9):3508-3516
No abstract available.
Lupus Erythematosus, Systemic*
;
Pregnancy*