No abstract available.

No abstract available.

So far today the blood Picture of specific dermatoses such as leprosy, syphilis, skin tubercuIosis, pemphigus and eczema was studied a good many ways. Author has studied the blood picture especially red blood cells, hemoglobin, hematocrit, white blood cells and its differential counts in 217 cases of various skin diseases such as contact. dermatitis, urticaria, chronic eczema, atoPic dermatitis, seborrheic dermatitis, erythema multiforme, erythemanodosum, drug eruption, prurigo, lichen urticatus, exfoliative dermatitis and purpura. At the same time liver function tests were performed in 46 cases including 25 cases of contact dermatitis, 6 cases of chronic eczema, 5 cases of atopic dermatitis, 5 cases of urticaria and 5 cases of exfolistive dermatitis. Afterwards the correlations of those two groups were investigated. Among all mentioned above dermatose except purpura no changes of red blood cells, hemogiobin and hematocrit were observed according to the authors own control of normal values which were obtained in 62 normal healthy adults. Other findings are as follows; 1. In contact dermatitis leucocytes and eosinophils are increased while neutrophils slightIy decreased. 2. Moderate increase of lymphocytes in urticaria. 3. In chronic eczema leucocytes and lymphocytes slightly increased but neutrophils somewhat decreased. 4. In atopic dermatitis leucocytes and eosinophils increased and there was also moderate increase of lyrnphocytes. 5. In seborreheic dermatitis monocytes and basophils were increased but eosinophils were slightly increased. 6. In erythema multiforme monocytes were decreased and leacocytes increased slightly. 7. In erythema nodosum neitrophils increased and lymphocytes and monocytes were decreased. 8. In drug eruption monocytes were decreased. 9. ln Prurigo eosinophils were increased. 10.:ln lichen uiticatus neutrophils were decreased. 11. In exfoliative dermatitis there are marked increase of leucocytes and eosinophils and decrease of neutrophiIs, lymphocytes and basophils. 12. In purpura red b!ood cells, hemoglobin, hematocrit were decreased. The increase of white blood cells in contact dermatitis and exfoliative dermatitis almost paralleled with the extension of their lesions. Marked liver function disturbarces were found in a good many cases cf exfoliativedermatitis while slight degree of liver function disturbances were found in some cases of contact dermatitis and it was found that some cases of chronic eczema, urticaria and atopic dermatitis gave some influence to liver function. The fact of leucocytes increase in exfoliative dermatitis and contact dermatitis seems more or less go parallels with liver function disturbances.
Adult ; Basophils ; Dermatitis ; Dermatitis, Atopic ; Dermatitis, Contact ; Dermatitis, Exfoliative ; Dermatitis, Seborrheic ; Drug Eruptions ; Eczema ; Eosinophils ; Erythema Multiforme ; Erythema Nodosum ; Erythrocytes ; Hematocrit ; Humans ; Leprosy ; Leukocytes ; Lichens ; Liver ; Liver Function Tests ; Lymphocytes ; Monocytes ; Neutrophils ; Pemphigus ; Prurigo ; Purpura ; Reference Values ; Skin Diseases* ; Syphilis, Cutaneous ; Urticaria

Statistical observation was made on 117 cases of malignant tumors in the urinary tract who had been admitted to Department of the Urology, St. Mary's Hospital from January 1, 1966 to May 31. 1972. Statistical observation included age, sex, clinical manifestation, annual distribution, organ distribution and methods of operation. The results were as follows; 1. Male patients were more common than female patients, and most of them were over the age of 40 years. Hematuria was the most common symptom, and other symptoms were pain, mass and dysuria. Operations were performed in 79 patients, and remaining patients were treated with radiation, chemotherapy and hormone therapy. 2. The urinary bladder was the most commonly involved organ, and other organs were in order of kidney, prostate and penis. Histologically, transitional cell carcinoma in the bladder was the most common and next in order was of renal cell carcinoma, Wilms' tumor and squamous cell carcinoma of penis.
Carcinoma, Renal Cell ; Carcinoma, Squamous Cell ; Carcinoma, Transitional Cell ; Drug Therapy ; Dysuria ; Female ; Hematuria ; Humans ; Kidney ; Male ; Penis ; Prostate ; Urinary Bladder ; Urinary Tract* ; Urology ; Wilms Tumor

Leiomyosarcoma of the breast is extremely rare. The natural history of leiomyosarcoma of the breast remains largely unknown because of the low incidence and lack of long-term follow up. But leiomyosarcoma of the breast appears to be less aggressive biologically than other sarcomas of the breast such as rhabdomyosarcoma. In an attempt to define diagnostic criteria of smooth muscle tumors of the breast, the reported cases of leiomyoma of the breast and nipple were also reviewed and compared with leiomyosarcomas by Chen et al(1981). Based on the result of this review, tumors with three or more mitoses per 10 HPF are leiomyosarcoma and those with no mitosis, necrosis, and significant atypia are leiomyomas. We have experienced a case of leiomyosarcoma of the breast. The patient was a 39 year-old female and was admitted due to a rapid growing right breast mass. The breast mass was noted 4 years ago and then this year the mass growed rapidly. Simple mastectomy was performed. Grossly the mass measured 11.0x8.0x8.0 cm in dimensions and was well circumscribed, pinkish, multinodular, and it was protruded from the cut surface. Microscopically the mass is composed of interlacing bundles of spindle shaped cells and multifocal large areas of hyalinized collagenous tissue. The individual spindle cells are slightly pleomorphic and occasionally show mitotic figures, 6~7 per 10 HPF in the most cellular area.
Female ; Humans ; Incidence

No abstract available.

No abstract available.

Recently, the importance of interferons as immune modulators has been recognized. Measurement of serum or tissue levels give only a partial picture of interferon activity, since antiviral effects persist after levels become undetectable. Neverthless, serum levels correlate reasonably well with clinical effects. Authors have analyzed the serum interferon levels in 12 patients with varicelIa and 25 with herpes zoster and the results are compared with healthy normal control. The results are as follows. The mean value of serum interferon levels showed no significant difference between patients group with varicella and with herpes zoster (8. 4+8, 5units/ml) and normal healthy control group (6. 2+7. 2 units/ml), 2, The mean value of serum interferon levels showed no significant difference between patients group with varicella (9. 2+7. 8 unit/ml) and normal healthy control group. 3 The mean value of serum interferon levels showed no significant difference between patients group with herpes zoster (8. I+9. 0 units/ml) and normal healthy control group. 4 The mean value of serum interferon levels showed no significant difference between patients group of varicella and those of herpes zoster.
Chickenpox ; Herpes Zoster ; Herpesvirus 3, Human* ; Humans ; Interferons*

It is generally accepted that erythropoiesis is controlled by the erythropoietic stimulating factor (erythropoietin) which is believed being produced in the kidney. Among the various causes. hypoxia is one of the most potent one for the stimulation of erythropoietin production in the kidney. This experiment was planned to determine the efficiency of the erythropoietin in the hydronephrotic kidney and the intact or disturbed liver function. Materials and Methods: The mongrel dogs weighing between 10 and 13 kg were used. Group A: A1: hydronephrosis due to bilateral ureteral ligation. A2: hydronephrosis due to bilateral ureteral ligation and testosterone injection. A3: hydronephrosis due to bilateral ureteral ligation and CCI4 intoxication. Group B: B1' bilateral nephrectomy. B2: bilateral nephrectomy and CCI4 intoxication. To observe the chemical constituents and erythropoietic activity blood sample were collected on 2, 4, 6. 8. 10th day after operation in the A group and 1, 2, 3. 4th day after operation in the B group. Chemical constituents were BUN, creatinine and electrolytes. Erythropoietic activity was determined by the incorporation of 59Fe into the red cells of mouse (DeGowin method). The results of the experiments were summarized as follows: 1. The hydronephrosis due to bilateral ureteral ligation induced increase of erythropoietic activities. 2. When testosterone was given in the group of the hydronephrosis due to bilateral ureteral ligation, erythropoietic activity was increased more than in the group of the hydronephrosis only. 3. The most prominent elevation of erythropoietic activities among any other group was confirmed when liver function was disturbed by CCl4 intoxication in the hydronephrotic animals. This marked elevation seemed to be due to the disturbance of the liver function which inactivated or destroyed erythropoietin. 4. Erythropoietin activity was decreased in the group of bilateral nephrectomy. 5. Erythropoietin activity was much less in the bilateral nephrectcmized group when liver was damaged by CCI. injection. The erythropoietic stimulation was ineffective in the nephrectomized animals. 6. Testosterone injection decreased the BUN and creatinine level in the uremic animals due to nephrectomy. 7. Pathological findings revealed mild hydronephrotic changes in the group of ureteral ligation by. testosterone injection, and mild degree of necrosis and severe fibrosis in the interstitial tissue of the kidney, and fatty changes and focal central necrosis of the liver due to CCl4 injection.
Animals ; Anoxia ; Creatinine ; Dogs ; Electrolytes ; Erythropoiesis ; Erythropoietin* ; Fibrosis ; Hydronephrosis ; Kidney ; Ligation* ; Liver ; Mice ; Necrosis ; Nephrectomy* ; Testosterone ; Ureter*

Xeroderma pigmentosum is a genodermatosis characterized by extreme sun sensitivity, photophobia, freckly hyperpigmentation, atrophy, telangiectases, keratoses and finally malignant degeneration of the skin. It is rare and prebobly inherrited as a recessive trait, Photosensitive cutaneous symptoms developed in complication with squamous cell ca is presented. A 20-year-old male were studied. Routine laboratory examinations were within normal limits including hemogram, urinalysis, blood urea nitrogen, serum creatinina, liver function tests(including bromsulphalaein excretion) and serum electrolytes, chest X-Ray. The histopathological picture showed characteristic xeroderma pigmentosum and squamous cell ca. Clinical, histopathological and biochemical features of this disease are also discuseed.
Atrophy ; Blood Urea Nitrogen ; Electrolytes ; Humans ; Hyperpigmentation ; Ichthyosis* ; Keratosis ; Liver ; Male ; Photophobia ; Skin ; Solar System ; Telangiectasis ; Thorax ; Urinalysis ; Xeroderma Pigmentosum* ; Young Adult