1.Early Radiology Findings of Lung Cancer.
Kyung Soo LEE ; Jung Hwa HWANG
Journal of the Korean Medical Association 1999;42(2):211-214
No abstract available.
Lung Neoplasms*
;
Lung*
2.A Study of the cPR Training Course for Nurse Teachers and Ambulance Drivers.
Kyung Hee KANG ; young Soo HAN ; Jung Yun HWANG
Journal of the Korean Society of Emergency Medicine 1997;8(3):353-361
No abstract available.
Ambulances*
;
Cardiopulmonary Resuscitation*
3.A radiologic findings of periappendiceal abscess : comparison of simple abdomen, B.E., and ultrasonography
Kyung Hee JUNG ; Jae Chun CHANG ; Mi Soo HWANG
Journal of the Korean Radiological Society 1985;21(6):975-984
With simple abdomen, double contrast colon study, and ultrasongraphy, authors retrospectively analyzedradilogic findings of 46 cases which were proved periappendiceal abscess, due to perforation of appendix, byhistology or follow-up ultrasnongraphy from May in 1983 to July in 1985 at Yeung-Nam University Hospital. Theresuls obtained were as follows: 1. Of 46 cases, 24 cases were males and 22 cases females, with the results ofabove statistics, periappendiceal abscess was not influenced by sex. 2. Periappendiceal abscess was mostfrequently demonstrated in forties. 3. Comparison of ultrasonography and B.E. Pseudorenal pattern(Ultrasonography)- well defined defect (B.E.) Cystic pattern(Ultrasonography)- serrated defect (B.E.) 4. Missed 2 cases inultrasonography were detected in B.E., i.e. sensitivity of B.E. is higher than that of ultrasonography. 5.Differences of ultrasonography and B.E.
Abdomen
;
Abscess
;
Appendix
;
Colon
;
Female
;
Follow-Up Studies
;
Humans
;
Male
;
Retrospective Studies
;
Sensitivity and Specificity
;
Ultrasonography
4.Changes of beta-lactoglobulin Specific Immunoglobulins According to the Age and the Onset of Cow's Milk Feeding.
Jong San LEE ; Soo Young CHO ; Pyoung Han HWANG ; Soo Cheol CHO ; Jung Soo KIM
Journal of the Korean Pediatric Society 1990;33(12):1639-1646
No abstract available.
Immunoglobulins*
;
Lactoglobulins*
;
Milk*
5.A Case of Wiskott-Aldrich Syndrome.
Byoung Geun LEE ; Soo Hee CHANG ; Soo Young CHO ; Pyoung Han HWANG ; Jung Soo KIM
Journal of the Korean Pediatric Society 1994;37(11):1615-1619
Wiskott-Aldrich Syndrome is an X-linked disorder characterized by recurrent infection, thrombocypenia and eczema. Various defects in cell-mediated immunity and deficient antibody reponse to carbohydrate antigens have been described. We experienced a case of Wiskott-Aldrich Syndrome of 28 months old male patient. He has been suffered from multiple petechiae with bleeding, recurrent pyogenic infections and generalized eczema since 3 months of age. Immunological abnormalities are as follows: 1) Serum IgM was gradually decreased, while IgA and IgE were increased. 2) Antibody response against polysaccharide antigen (PRP) was not observed after 3 times of PRPT immunization. 3) CD4/CD8 ratio was reversed (0.6). 4) Proliferative response of mononuclear cells was significantly reduced, and CMI skin test also showed negative results. A brief review of literature was made.
Antibody Formation
;
Child, Preschool
;
Eczema
;
Hemorrhage
;
Humans
;
Immunity, Cellular
;
Immunization
;
Immunoglobulin A
;
Immunoglobulin E
;
Immunoglobulin M
;
Male
;
Purpura
;
Skin Tests
;
Wiskott-Aldrich Syndrome*
6.Placental Transfer of Anti-H. influenzae Type b Specific IgG and Subclasses.
Soo Hee CHANG ; Moon Hwan LEE ; Pyoung Han HWANG ; Soo Chul CHO ; Jung Soo KIM
Journal of the Korean Pediatric Society 1995;38(12):1638-1644
No abstract available.
Immunoglobulin G*
;
Influenza, Human*
7.The Effect of Milk on the Bioavailability of 6-mercaptopurine.
Sun Kyu PARK ; Ran Ju KIM ; Pyoung Han HWANG ; Soo Chul CHO ; Jung Soo KIM
Journal of the Korean Pediatric Society 1994;37(12):1732-1737
The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoblastic leukemia. The bioavailibility, clinical efficacy and toxicity of 6-MP administered orally for maintenance therapy of children with acute lymphoblastic leukemia are highly variable in many studies, as well as at differnt times in same patient. there are many factors affecting the bioavailibility of 6-MP. The most notably factor being that concomitantly administered drugs and foods might contribute to a decrease in the bioavailibity of this drug. In our sociocultural environment milk is a major constituent of child's foods. Cow's milk contains a high concentration of xanthine oxidase, which could potentially transform 6-TM into 6-thioxanthine (6-TX) and 6-thiouric acid (6-TUA) which have no more therapeutic effects. In this study, we evaluated the effect of various milk products on the bioavailability of 6-MP. Incubation at 37degrees C for 30 min raw or pasteurized milk resulted in transformation of a large quantity of clinically relevant concentration of 6-MP into 6-TUA. The concomitant adminstration of folic acid and allopurinol has markedly inhibitory effect on the 6-MP destroying activity of milk at clinically relevant concentrations. These observations may help to optimize modalities of administration of 6-MP for the treartment of patients with childhood leukemia.
6-Mercaptopurine*
;
Allopurinol
;
Biological Availability*
;
Child
;
Complement Factor B
;
Folic Acid
;
Humans
;
Leukemia
;
Milk*
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
;
Xanthine Oxidase
8.Two Cases of Anomalous Origin of the Right Pulmonary artery from the Ascending Aorta.
Kyu Gap HWANG ; Gu Soo KIM ; Jung Yun CHOI ; Yong Soo YUN ; Chang Yee HONG
Journal of the Korean Pediatric Society 1984;27(5):501-505
No abstract available.
Aorta*
;
Pulmonary Artery*
9.A Cases of Heredotary Anhidrotic Ectodermal Dyslasia.
Jong Soo KIM ; Pyoung Han HWANG ; Hyeon Sook LEE ; Jung Soo KIM
Journal of the Korean Pediatric Society 1983;26(10):1018-1023
No abstract available.
Ectoderm*
10.Survival, Differentiation and ATM Phenotype of PC-12 Cells by Down - regulation of AT Gene.
Ho Keun YI ; Soo Hee CHANG ; Dae Yeol LEE ; Jung Soo KIM ; Pyoung Han HWANG
Journal of the Korean Cancer Association 1999;31(5):1065-1073
PURPOSE: Ataxia Telangiectasia (AT) is a hereditary multi-systemic disease resulting from mutations of AT gene and is characterized by progressive neurodegeneration, cancer, immune system defects, and hypersensitivity to ionizing radiation. AT gene has a homologue sequence of PI3-kinase. The activity and cellular function of PI3-kinase in AT gene remains unclear. This study was undertaken to evaluate the function of AT gene through the effect on cell survival and differentiation by the inhibition of AT gene expression. MATERIALS AND METHODS: NH2-terminal portion of AT gene was isolated from MCF-7 cells by RT-PCR. The isolated DNA fragment was ligated in reverse orientation in pcDNA3. This antisense ATM expression vector was transfected to PC-12 cells by calcium phosphate method, and the transformed cells were selected using G418 and immunohisto- chemistry. To analyze the cell survival and differentiation, cells were cultured in serum free medium supplemented with/without NGF. We performed the immunoprecipitation for the p53 induction of cells after ionizing radiation, and the FACS for the apoptosis of cells after the exposure of wortmanin. RESULTS: PC-12 cells which down-regulated AT gene (like ATM, AT mutated) showed decreased survival and ceased differentiation with NGF. Also, PC-12 (ATM) cells showed increased apoptosis with wortmanin and reduced or delayed p53 induction after ionizingradiation. CONCLUSION: Results obtained from these studies suggest that AT gene regulates survival and differentiation of PC-12 cells through PI3-kinase activity. It seems that apoptosis is induced by the inhibition of AT gene expression.
Apoptosis
;
Ataxia Telangiectasia
;
Calcium
;
Cell Survival
;
Chemistry
;
DNA
;
Gene Expression
;
Hypersensitivity
;
Immune System
;
Immunoprecipitation
;
MCF-7 Cells
;
Nerve Growth Factor
;
Phenotype*
;
Phosphatidylinositol 3-Kinases
;
Radiation, Ionizing