Generalized pustular psoriasis is a severe form of paoriasis and is frequently associated with arthritis and nail deformity. We present a case of generalized pustular psoriasis in a 40 year-old man, with nail change, arthritis of both knee and ankle joints, spondylitis, and glomerulonephritis. We found a positive results of HLA A-9, B-27 in this patient. Skin lesions, arthralgia and hematuria improved marked1y by plasmapheresis and application of topical corticostertoid.
Adult ; Ankle Joint ; Arthralgia ; Arthritis* ; Congenital Abnormalities ; Glomerulonephritis* ; Hematuria ; Humans ; Knee ; Plasmapheresis ; Psoriasis* ; Skin ; Spondylitis*

We report herein a case of eosinophilic pustular follicultis in a 20-year-old man. The patient showed typical clinical picture with specific laboratory and histopathological findings of eosinophilic pustular folliculitis. The patient responded well to systemic administration of corticosteroid and dapsone.
Dapsone ; Eosinophils* ; Folliculitis* ; Humans ; Young Adult

It is well known that Bowen's.disease, a precancerous dermatosis can be associated with internal malignancy. We report 2 cases of Bowen's disease of probable arsenic origin associated with. internal malignancies. Case one, a 55 year-old man, who had the past history of arsenic intake and herb medication for the treatment of suspicious leprosy, had Bowen's disease and arsenical keratosis on his palms and soles with bronchogenic and stomach carcinoma. The other case, a 65 year-old man, who had history of intake of arsenic and herb medicine for epilepsy, had Bowen's disease and squamous cell carcinoma of the skin with stomach cancer. We suggest that in these 2 cases, the ingestion of organic arsenics might be the causative factor for the internal malignancy.
Aged ; Arsenic ; Bowen's Disease* ; Carcinoma, Squamous Cell ; Eating ; Epilepsy ; Humans ; Keratosis ; Leprosy ; Middle Aged ; Skin ; Skin Diseases ; Stomach ; Stomach Neoplasms

Solar urticaria is a fairly uncommon but Well recognized clinical entity characterized by erythema and wheal with itching immediately following exposure to sunlight or artifical radiation. A 33-year-old female had a six-year duration of urticaria, tightness of chest and dizziness that appeared within 15 minutes of exposure to sunlight. The action spectrum of this patient was between 320 and 400nm and the passive and reverse passive transfer test were negative. Solar urticaria of our patient appeared to belong to type g in the classification of Harber et al(1963). The patient was treated with antihistamines and repeated exposure to sunlight for inducing tolerance. After 3 months of the treatment, the symptoms did not appear even after 3 hours of exposure to sunlight.
Adult ; Classification ; Dizziness ; Erythema ; Female ; Histamine Antagonists ; Humans ; Intradermal Tests ; Pruritus ; Sunlight ; Thorax ; Urticaria*

No abstract available.
Hyperpigmentation*

The cystic hypersecretory duct carcinoma of the breast was first described in 1984 by Rosen and Scott and warrants separate discussion because of its unusual pathological features. It is morphologically distinguishable from juvenile (secretory) carcinoma and from mucinous (colloid) carcinoma or mucocele-like tumor. We present a case report of intraductal cystic hypersecretory carcinoma of the breast with hormone receptor and oncogene study. The histologic differential diagnosis, with an emphasis on benign lesions that may have a predominant cystic component, is also discussed.
Breast Neoplasms ; Breast* ; Diagnosis, Differential ; Mucins ; Oncogenes

No abstract available.
Acromioclavicular Joint* ; Classification* ; Dislocations*

BACKGROUND: To investigate the effect of manganese on lipid peroxidation and compositional changes of fatty acids in hippocampus of rat brain. METHODS: Seven rats in experimental group were given with MnCl2 intraperitoneally for 4 weeks (4 mg/kg once daily, 5 days per week). Twenty four hours after the last injection, rats were decapitated and, hippocampus were separated from the rat brain. RESULT: In Mn-treated group, manganese concentrations increased significantly in the hippocampus by 222% compared with control group (P<0.01). MDA concentrations increased significantly by 149% compared with control group (P<0.05). Among fatty acids, total n-6 polyunsaturated fatty acids (PUFAs) increased significantly by 237% compared with control group (P<0.05). Linoleic acid (LA) and arachidonic acids (AA) increased by 213%, 238% (P<0.05, P<0.01, respectively). Among n-3 PUFAs except linolenic acids, eicosapentanoic acid(EPA) and docosahexanoic acids (DHA) decreased significantly by 70%, 50% respectively compared with control group (both P<0.01). CONCLUSION: Our results suggest that manganese may cause compositional changes of fatty acids in hippocampus of rat brain. Characteristics of fatty acids compositional changes by manganese were the decrease of EPAs and DHAs (n-3 PUFAs), and increase of AA and LA (n-6 PUFAs). These changes with the increase of MDA, suggest that manganese neurotoxicity is caused by lipid peroxidation.
alpha-Linolenic Acid ; Animals ; Arachidonic Acid ; Arachidonic Acids ; Brain* ; Fatty Acids* ; Fatty Acids, Omega-3 ; Fatty Acids, Unsaturated ; Hippocampus* ; Linoleic Acid ; Linolenic Acids ; Lipid Peroxidation* ; Malondialdehyde ; Manganese* ; Rats*

No abstract available.

Botulinum toxin A injection to reduce glabellar lines has become one of the most popular procedures in facial rejuvenation. 5-site injection is generally accepted: into the procerus muscle at the midline and each corrugator muscle at its inferomedial and superolateral aspects. The superolateral injection site is above the pupil and approximately 1cm above the bony orbital rim. According to our observation, corrugator muscles are not either symmetric or tightly related to the surface anatomical landmarks such as pupils and bony orbital rims. Therefore when glabellar lines were treated by surface anatomical landmarks, in the case of asymmetrical corrugator, it was not precisely targeted to obtain sufficient paralytic effects. Herein, we suggest functional anatomy-based Botulinum toxic A injection to correct glabellar frown lines and its theoretical backgrounds. Between 1999 and 2007, 329 patients were enrolled in the study. 86 patients between 1999 and February of 2001 were injected by the traditional injection method. Later 243 patients were treated by the functional anatomy-based injection. By the new method, injection points were determined by observing glabellar furrows and skin fine wrinkles after repetition of muscle contraction. By this method, we could enhance the cosmetic effects and heighten patients' satisfaction.
Aging ; Botulinum Toxins ; Cosmetics ; Humans ; Muscle Contraction ; Muscles ; Orbit ; Pupil ; Rejuvenation ; Skin