No abstract available.
Genetic Therapy*

We report the FDG PET findings in a patient with Marchiafava-Bignami disease (MBD) in whom there was diffusely reduced metabolism in the whole brain cortex and strongly decreased metabolism in the thalami. The use of FDG PET helps provide an understanding of the neurologic manifestations and prognosis of MBD.
Alcoholism ; Brain ; Humans ; Marchiafava-Bignami Disease* ; Metabolism ; Neurologic Manifestations ; Prognosis

No abstract available.
Immunoglobulins* ; Streptococcal Infections*

In the 21st century, the number of elderly population will reach 10% of Korean's total population, As the elderly population are increasing, the anticipation of the elderly with chronic health problem are also increased. They feel social isolation, alienation because of pain, and psychological flinching such as depression, but they can not control appropriately their chronic pain. Therefore, this study is an attempt to expose a group reminiscence therapy effect to decrease pain and depression, increasing self-esteem of the elderly as effective therapeutic nursing intervention This study is conductcd for 5 weeks from July 28 to August 31, 1997. The Subjects of this study consisted of 33 the elderly women having ronic pain. 17 of 33 residents S nursing home were ontrol group in C city. 16 of 33 resident E nursin home were experimental group in M city. The study design was a nnneqi.uivalent nontrol group with a pretest-posttest design. As for the tool for this study, Visual An logue Scale and Discriptive rating Scale were u ed to measure the pain, Zung's Depression Status nventory(DSI) which was translated by Yang S k Ha was used to measure the depression, and self-esteem scale which was translated by Byung Jae Jeon was used Lo measure self-esteem. As for the process of the study, demo raphic variables, pain, depression, self-esteem were tested with both the experimental and control grou prior to the group reminiscence. The ezperimental group was divided into 3 subgroup and a total of 4 ession of the group reminiscence therapy was performed to the experimental group for an hour at a time once a week from the first to the fourth week. Analysis of this study was computerized by using SPSS/PC. and the homogeneity which may be affected by various bariables was verifie with Chi-square and t-test, the reliablity of th tools with Cronbach's alpha, the comparison of pre and post-test with t-test in the Pain, Depression, and Self-Esteem among the experimental group and control group. The Pearson Corelation Coefficient was for analysis the relation of the Pain, Depression and Self-esteem. The results of the study can be summarized as follows ; 1. The first hypothesis, the degree of pain will be decreased on the experimental group which performed group reminiscence therapy than that of control group, was supported. VAS(t = -2.35, p=.025), DRS(t= -2.11, p=O.43). 2. The second hypothesis, the degree of depression status of the experimental group which has perfomed group reminiscence therapy will be reduced than control group was supported(t= -2.53, p= .017). 3. The third hypothesis, self-esteem of the experiinental group which has performed group reminiscence therapy will be increased than that of control group was not supported(t=1.34, p= .191). 4. The fourth hypothesis, the correlation with pain, depression, self-esteem was to appeared highly. The significance of this study through the above results shows that the Group Reminiscence Therapy is an effective nursing intervention for the elderly with chronic pain and depression.
Aged* ; Chronic Pain* ; Depression* ; Emigrants and Immigrants ; Female ; Humans ; Nursing ; Nursing Homes ; Social Isolation

No abstract available.
Humans ; Infant, Newborn* ; Spectrum Analysis*

No abstract available.
Animals* ; Clone Cells*

No abstract available.
Genetic Predisposition to Disease*

No abstract available.
Urinary Bladder*

No abstract available.
Thinking*

BACKGROUND: The renin-angiotensin system (RAS) plays a crucial role in pathophysiology of congestive heart failure and ventricular remodeling after myocardial infarction (MI). There are two components, systemic and local, in RAS. There has not been a study to analyze differentially the sequential changes of systemic and local RAS after MI. The aim of this study was to analyze the sequential change of the expression of angiotensinogen mRNA, the first component of the renin-angiotensin system, in liver and non-infarcted myocardium in rats after myocardial infarction. METHOD: Female Sprague-Dawley rats (body weight 200-250 g) were subjected either to left coronary artery occlusion or to sham operation. And the rats were sacrificed at 1, 4, 18, 24 hours, 3 days, 2, 3 weeks. Hemodynamic measurement was performed and RNA was extracted from various tissues including liver and ventricle for the analysis of the expression of the angiotensinogen mRNA by northern blot analysis or RT-PCR. RESULTS: Coronary artery ligation resulted in comparable infarct sizes among rats at 3 weeks after MI and was accompanied by significant increases of LVEDP (preMI 11+/-2 vs postMI 21+/-3 mmHg, n=4). Systolic arterial pressure was reduced in animals with infarction (preMI 130+/-15 vs postMI 90+/-10 mmHgn n=4). The liver angiotensinogen mRNA levels increased at 4, 18, 24 hours after myocardial infarction and decreased at 3rd day to control values (Angiotensinogen/GAPDH;preMI 1.35+/-0.20 vs postMI 5.97+/-0.25, max 4-fold, n=3). After sham operation, the liver angiotensinogen mRNA levels increased also at 4, 18, 24 hours, but in a less degree (Angiotensinogen/GAPDH;preop. 2.15+/-1.17 vs postop. 3.41+/-1.76, max 1.5-fold, n=3). In contrast to the liver, small amounts of angiotensinogen mRNA were detectable in normal left ventricle of rat with RT-PCR. The myocardial angiotensinogen mRNA levels decreased transiently in acute phase after MI, and recovered at 3-day after MI and increased further afterwards upto 3rd month after MI. CONCLUSION: The angiotensinogen in liver was activated early during acute phase after MI and decreased toward normal as the stable state was achieved. In contrast to the circulating RAS that was activated in acute phase after MI, the local RAS in heart was activated in chronic phase after MI.
Angiotensinogen* ; Animals ; Arterial Pressure ; Blotting, Northern ; Coronary Vessels ; Female ; Gene Expression ; Heart ; Heart Failure ; Heart Ventricles ; Hemodynamics ; Humans ; Infarction ; Ligation ; Liver* ; Myocardial Infarction* ; Myocardium* ; Rats* ; Rats, Sprague-Dawley ; Renin-Angiotensin System ; RNA ; RNA, Messenger* ; Ventricular Remodeling