No abstract available.
Survival Analysis*

No abstract available.
Animals* ; Clone Cells*

No abstract available.

No abstract available.
Thinking*

Conflicting results have been reported, as to whether or not wound repair is influenced following treatment with low doses of prednisolone, insulin, or thyrotrophic hormone. The present studies were undertaken to evaluate and compare the influence of above hormones on the wound repair process and their target organs in rats at different times after operation. The influence of the above hormones were observed as measurement of the tensile strength of healing skin incisions and the histologic finding of the wound sites and the target organs staining with H-E, PAS, and Masson's trichrome method. Saline 0. 1 ml were injected daily intramusculary in control group: prednisolone acetate 0. 2ml (4mg/kg/day) in prednisolone treated group: regular zinc insulin 0.1 ml(1.5IU/kg/day) in insulin treated group; thyrotrophin 0.1 ml (0.4IU/kg/day) in TSH trcated group. The observation period wer at 4th day, 7th day, 14th day and 21st day of post-operation. The results were as follows: 1. Prednisolone treated group: (1) The tensile strength were decreased at 4th and 7th day than control groups, but there were no statistically significant difference at 14th and 21st day from control group. (2) In histologic findings of the wound sites at 4th and 7th day, the repair processes were suppressed, but at 14th and 21st day, there were no difference from control group. (3) In histologic finding of adrenal cortex, the atrophic changes was observed from early stage. 2. Insulin treated group: (1) There were no statistical difference from control group in tensile strength at each observation period. (2) In histologic findings of the wound sites, the pictures of the repair processes were similar with control group at each observation period. (3) Atrophic change of islets of Langerhans in pancreas was observed at each observation period. 3. TSH treated group: (1) The tensile strength were increased at 4th, 7th, and 14th day than control group, but there was no statistical difference at 21st day frorn control group. (2) In histologic findings of the wound sites, the repair processes were aecelerated at 4th and 7th day than control group, but there were no defferences at 14th and 21st day from control group. (3) Hyperplastic change of acini in thyroid gland was observed through entire observation period.
Adrenal Cortex ; Animals ; Insulin ; Islets of Langerhans ; Pancreas ; Prednisolone ; Rats ; Skin ; Tensile Strength ; Thyroid Gland ; Thyrotrophs ; Thyrotropin ; Wounds and Injuries* ; Zinc

Fabricating human organs with tissue engineering and stem cells may be an alternative to current suboptimal therapies for treatment of malfunction or loss of human tissues or organs. From the tissue engineering's perspective, the patients are expected to be treated with new tissues or organs reconstructed with transplanted cells. The cells for tissue engineering could be somatic cells derived from the patients themselves, other individuals, or animals. Another valuable cell source would be stem cells. Embryonic stem cells retain the pluripotency to differentiate into every cell type of human organs, but ethical issues remain to be addressed. Adult stem cells may solve these ethical issues and immune rejection, but have limitation in differentiation into all ranges of tissue-specific cell types. Tissue engineering typically employs scaffolds fabricated from synthetic or natural biomaterials to engineer a new functional tissue from cells. The configuration of the biomaterials guides the structure of a regenerated tissue by defining a three-dimensional space. Appropriate combination of tissue engineering with stem cells shows a promise to fabricate human organs or tissues that can be utilized for patients in the near future.
Adult Stem Cells ; Animals ; Artificial Organs ; Biocompatible Materials ; Embryonic Stem Cells ; Ethics ; Humans ; Stem Cells* ; Tissue Engineering*

No abstract available.
Urinary Bladder*

No abstract available.
Lymphocytes* ; T-Lymphocyte Subsets* ; Thyroid Gland*

No abstract available.
Aged* ; Humans

No abstract available.
Genetic Predisposition to Disease*