A clinical and histopsthological study were done on 1,817 biopsied inflammatory skin diseases among 58,386 out-patients in Dermatologic department of Korea University Hospital during the period of 24 years from January, 1962 to December, 1985. The results were summarized as follows : 1. According to pattern analysis(Ackerman AB), 1,605 cases(88.3%) of inflammatory skin diseases were classified into 9 patterns and by author's modified pattern analysis, additional 437 cases could be classified. 2. Of the 1605 cases which were classified by 9 pattern analysis, 1185 cases(78.8%) of inflammatory skin diseases were diagnosed as individual disease entity. The ratio of accordance between the histopathological diagnosis and clinical diagnosis on the biopsied inflammatory skin diseases was 44.5%, 3. The ratio of accordance between the histopathological diagnosis and clinical diagnosis by the patterns were '. Vasculitis(75.5%), Subepidermal vesicular dermatitis (73.3%), Nodular and diffuse dermatitis(68.2%), etc. 4. The diseases showing above the 70% accordance were scleroderma, erythema induratum, vitiligo, arthropod reaction, etc; and the diseases showing under the 30% accnrdance were erythema multiforme, erythema annulare centrifugum, neurodermatitis, etc.
Arthropods ; Biopsy* ; Dermatitis ; Diagnosis ; Erythema ; Erythema Induratum ; Erythema Multiforme ; Humans ; Korea ; Neurodermatitis ; Outpatients ; Skin Diseases* ; Skin* ; Vitiligo

Clinical analysis was done on 60 meniscus injuries operated on at Orthopaedic Department of Capital Armed Forces General Hospital from Mar. 1977 to Sept. 1978 with the following results. 1. All cases were military personel aged from 21 to 40, most of them 23 and 24 years old. 2. The fall down accident was the most common cause of injury mechanism. 3. The lateral meniscus was more frequently injured than the medial with 43:17, and the right side knee than left with a ratio of 35:25. 4. The posterior horn tear was the most common type of the injuries involved 23 cases (48.3%). 5. The complete healing after menisectomy ranged from 1 month to about 3 months. 6. It seems resonably certain that habit of exaggerated flexion of the knee in Korean is an important factor in the production of the lesion, combined possibly with medial ratation of the tibia, for subsequent episodes of the exaggerated flexion enlarge the rent untill the popliteus attachment and all peripheral attachments behind the hiatus are torn away, and the posterior half of the lateral meniscus is released from normal control.
Animals ; Arm ; Horns ; Hospitals, General ; Humans ; Knee ; Menisci, Tibial ; Military Personnel ; Tears ; Tibia

A 72-year-old woman with a pea sized, bluish, firm nodule was diagnosed as having a cellular type of dermatofibroma histopathologically. A biopsy specimen revealed a relatively well circumscribed, non-encapsulated, nodular infiltration of irregularly distributed histiocytes in the deep dermis. Foam cells were also noted. Gomoris iron stain revealed large amounts of hemosiderin deposits and some collagen were present as individual fibers in the lesion with Masson's trichrome stain.
Aged ; Biopsy ; Collagen ; Dermis ; Female ; Foam Cells ; Hemosiderin ; Histiocytes ; Histiocytoma, Benign Fibrous* ; Humans ; Iron ; Peas

No abstract available.
Child* ; Cyclophosphamide* ; Humans ; Nephrotic Syndrome* ; Retrospective Studies*

The results regarding an association between the polymorphism sites in the dopamine D1 receptor gene and schizophrenia compelled us to study the distribution of the polymorphism in Korean schizophrenia and controls. Eighty-eight schizophrenic patients and normal controls were examined by case-control study for distribution of the polymorphism of the dopamine D1 receptor gene in Korean popualtion to minimize the effect of racial differencies in gene frequencies. The frequencies of the B1 and B2 in schizophrenic patients were 0.11 and 9.89, respectively. And 0.10 and 0.90 in normal control. There was no significant differences in the frequencies in the allele B1 and 2 between schizophrenic patients and normal controls. The author present here the evidence of a lack of alleic association between the polymorphism of the dopamine D1 receptor gene and Korean schizophrenic. The assumption that the dopamine D1 receptor gene has genetic role in the development of schizophrenia was not supported by this case-control study.
Alleles* ; Case-Control Studies ; Dopamine* ; Gene Frequency ; Humans ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; Schizophrenia*

Epidermolysis bullosa simplex (EBS) is a group of autosomal dominantly inherited genetic disorders characterized by blistering due to mechanical- stress-induced degeneration of basal epiderrnal cells. Recently, it was discovered that EBS is induced by keratin 5 and 14 gene mutations. Weber Cockayne (W-C) EBS is the mildest type, with blistering concentrates primarily on palar and plantar regions, and basal cell cytolysis by keratin filament perturbations is present. Herein we report a case of W-C EBS with its ultrastructural findings. Electron microscopy showed cytolysis and separation of the basal epidermal cells, mainly at the subnuclear cytoplasm. The cyto- plasm of basal cells showed edema, loosening and intact rnitochondria. Besides the cytoplasmic changes, the nucleus also showed lytic degeneration. Characteristically, dense condensation of tonofilarnent was observed, which suggests that W-C EBS is. also a disorder of keratin.
Blister ; Cytoplasm ; Edema ; Epidermolysis Bullosa Simplex* ; Epidermolysis Bullosa* ; Keratin-5 ; Microscopy, Electron

The cutaneous mucinose are a group of connective disorders characterized by the deposition of mucin in the dermis. Thc disease may be a primary (metabolic) or secondary (catabolic). Secondary mucinosis is common in lupus erythematosus and dermatomyositis but rare in morphea. We report a case of guttate morphea with secondary cutaneous mucinosis.
Dermatomyositis ; Dermis ; Dronabinol ; Mucinoses* ; Mucins ; Scleroderma, Localized*

The case of a 56-year-old woman with a keratoacarithoma(KA) of the labial mucosa is herein reported, The tumor was excised and the pathological features were characteristic of a KA, This case is reported because the oral mucosa is such an unexpected location for solitary KA and the labial mucosa of this patient received chronic actinic damage, which suggested an etiological relationship. Follow-up examination of the patient after four months showed no recurrence.
Actins ; Female ; Follow-Up Studies ; Humans ; Keratoacanthoma* ; Middle Aged ; Mouth Mucosa ; Mucous Membrane* ; Recurrence ; Solar System*

Multiple satellite pyogenic granuloma developed on the left upper back of a 14-year-old boy after excision of a hemangioma-like lesion. He has had nevus flammeus on the left upper arm since birth with fine linear telangietasiae around the main lesions. Histopathology showed the capillary proliferation in the dermis, and transmission electron microscopy revealed multiple Weibel-Palade bodies, considered an early endothelial cell marker, in the cytoplasm of the endothelial cells. We believe this patient may have the propensity to develop different angiomatous lesions.
Adolescent ; Arm ; Capillaries ; Cytoplasm ; Dermis ; Endothelial Cells ; Granuloma, Pyogenic* ; Humans ; Male ; Microscopy, Electron, Transmission ; Parturition ; Port-Wine Stain ; Weibel-Palade Bodies

We report herein a case of multiple glomus tumors on the scrotum in a 14-year-old boy. The lesions were present at birth and had gradually increased in size and number. Pea to thumb tip sized, dark colored nodules without pain sensation were confined to the scrotum. Histopathologically, there were many dilated and irregular vascular spaces lined by a single layer of flattened endothelial cells in the dermis. In the periphery of the endothelial cells, there are a few layers of glomus cells. No capsule was seen. Total excision of the tumors was performed. No recurrence was observed for an year after surgical excision.
Adolescent ; Dermis ; Endothelial Cells ; Glomus Tumor ; Humans ; Ichthyosis* ; Male ; Parturition ; Peas ; Recurrence ; Scrotum ; Sensation ; Thumb