No abstract available.
Biopsy* ; Prostate*

We made a clinical obserration of 84 cases of congenital syphilis at the pediatric department of Hanyang University Hospital in Seoul, Korea during the preiod from July, 1972 to June, 1978. The results were as following: 1. The incidence of congenital syphilis in the newborn infants delivered at the nursery was 0.47% among fullterm babies (28cases/6,056 born alive) and 2,31% among premature babies(8 cases/346 born alive) during the above mentioned period. 2. The incidence of congenital syphilis was 0.42% among all patients of pediatric ward(37cases/8,711) and 0.02% among all out patients of pediatric department (11cases/52,832)during the same above mentioned period. 3. Male to female sex ratio was about 2.2:1. 4. In the newborn nursery, 33.3%(20 of total 36 Pts) were under 2,500gm of birth weight and 20.5%(16 of total 36Pts) were under 37 wks of gestational periods. 5. 73%(35 of total 48Pts)of congenital syphilis in th OPD and ward of pediatric department had the onset of the first clinical feature within one month after birth. 6. The principal clinical features of congenital syphilis observed from the O.P.D. and ward of pediatric dept. were hepatosplenomegaly 62%(52 cases), skin manifestations 60.7%(51 cases), jaundice 31%(26 cases) and nasal stuffness and /or rhinitis 28.6%(24 cases) inorder. 7. In the examination of peripheral blood, anemia was shown in 70%, leukocytosis in 45% and leukemoid reactions in 10% of them. 8. Syphilitic bone changes in the bone X-ray films were detected in 35.7% of all 28 observed cases. 9. The complications or combined diseases were pneumonia (10 cases), sepsis (9 cases), tetanus (2 cases), meningitis (1 case), respiratory distress syndrome( 1 case) and congenital heart anomaly(1 case). 10. The mortality rate was 12% (10 cases/84)
Anemia ; Birth Weight ; Female ; Heart ; Humans ; Incidence ; Infant, Newborn ; Jaundice ; Korea ; Leukemoid Reaction ; Leukocytosis ; Male ; Meningitis ; Mortality ; Nurseries ; Outpatients ; Parturition ; Pneumonia ; Rhinitis ; Seoul ; Sepsis ; Sex Ratio ; Skin Manifestations ; Syphilis, Congenital* ; Tetanus ; X-Ray Film

No abstract available.
Cartilage* ; Congenital Abnormalities*

No abstract available.
Urinary Tract*

No abstract available.
Blepharophimosis* ; Humans

No abstract available.
6-Cyano-7-nitroquinoxaline-2,3-dione* ; Cycloheximide* ; Dizocilpine Maleate*

INTRODUCTION: Premature ejaculation is the most prevalent form of male sexual dysfunction, but its cause has not been well established. Recently some studies indicated that penile sensitivity is decreased in men with premature ejaculation. MATERIALS AND METHODS: To clarify the association between penile sensitivity and premature ejaculation, we evaluated penile sensitivity in 18 patients with premature ejaculation without erectile dysfunction and neurologic deficit, and 15 normal potent male volunteers by SMV-5 digital vibrometer (Teknologue, Tokyo, Japan), which has higher precision and reproducibility than analogue type biothesiometers. Vibration thresholds were recorded at the glans penis, penile shaft, and frenulum of the penis in flaccid and erectile state induced by PGE1 10 ug. We also recorded those at ulnar process and medial maleolus of the tibia. RESULTS: There was no difference in vibration threshold at the ulnar process and the medial maleolus of the tibia between the two groups (p>0.05). And we found no difference in penile sensitivity at the glans penis, penile shaft, frenulum of the penis between the two groups, in both erectile and flaccid states (p>0.05). Penile sensitivity was decreased in erectile state compared to flaccid state, but it is not statistically significant (p>0.05). CONCLUSION: Based on our results, penile hypersensitivity measured by SMV-5 vibrometer does not appear to be a major factor contributing to premature ejaculation. And further study aimed at other somatic or cognitive factors awaits implementation.
Alprostadil ; Erectile Dysfunction ; Humans ; Hypersensitivity ; Male ; Neurologic Manifestations ; Penis ; Premature Ejaculation* ; Tibia ; Vibration ; Volunteers

Pulmonary artery sling is a rare congenital condition in which the left pulmonary artery arises anomalously fmm the right pulmonary artery extrapericardially and encirdes the right main stem bronchus and passes between the trachea and esophaghus to reach the hilum of the left lung. Respiratory obstruction vesults from compression of the lower area of trachea and right main stem bronchus. It is rare cause of respiratory distress in the new bom and may be associated with significant morbidity and mortality. We experienced the case of pulmonary artery sling with diffuse trachea stenosis and congenital heart disease (pulmonary atresia and PDA) and confirmed the anomaly by bronchogram and MRI. The presumed cause of death was respiratory obsruction due to pulmonary artery sling.
Bronchi ; Cause of Death ; Constriction, Pathologic ; Heart Defects, Congenital ; Lung ; Magnetic Resonance Imaging ; Mortality ; Pulmonary Artery* ; Trachea ; Tracheal Stenosis*

No abstract available.
Epidermal Growth Factor* ; Humans*

PURPOSE: Immunotherapy with tumor cell vaccines has shown limited success in established tumors, for reasons including suppressed expression of MHC molecules or absent tumor associated antigens, and active production of immunosuppressive molecules of tumor cells. The development of a vaccine targeting tumor angiogenesis might overcome the limitation of tumor cell vaccines. MATERIALS AND METHODS: Human umbilical vein endothelial cells(HUVEC) were infected with 20MOI of Ad-CMV-mGMCSF, and GM-CSF expression was measured by ELISA assay. One million mouse bladder cancer cells (MBT-2) were subcutaneously inoculated in C3H mice. The growth of tumors was measured after weekly intraperitoneal injection of saline(group I), HUVEC cells(group II), and HUVEC cells infected with Ad-CMV- mGMCSF(group III). At 4 weeks, the tumors were immunostained with anti-CD31 and the microvessel density(MVD) was measured. To evaluate the mechanism of this vaccine, flow cytometry analysis for activated CD4 and CD8 was performed. RESULTS: The mean expression of GM-CSF was 215ng/106 HUVEC cells at 24 hours after infection. There was no significant difference in tumor growth between groups I and II. However, the tumor growth in group III was significantly suppressed compared to that in groups I and II(p<0.05), as was MVD(p<0.05). In flow cytometry analysis, activated CD4 and CD8 cells were increased in group III compared to those of groups I and II. CONCLUSIONS: GM-CSF producing endothelial cell vaccine suppressed the growth of established bladder tumors, which may be explained by specific T cell mediated immune reaction to the tumor angiogenesis.
Animals ; Endothelial Cells* ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Granulocyte-Macrophage Colony-Stimulating Factor ; Human Umbilical Vein Endothelial Cells ; Humans ; Immunotherapy ; Injections, Intraperitoneal ; Mice ; Mice, Inbred C3H ; Microvessels ; Umbilical Veins ; Urinary Bladder Neoplasms ; Vaccines