1.The effect of the timing of human chorionic gonadotropin on in vitro fertilization.
Hyang Mee KIM ; Young Soo KANG ; Mi Ja LEE ; Young Soo SON ; Bock Hi WOO
Korean Journal of Obstetrics and Gynecology 1993;36(7):1725-1733
No abstract available.
Chorionic Gonadotropin*
;
Fertilization in Vitro*
;
Humans*
2.Immunohistochemical Evaluation of HMB-45 and S-100 Protein in Melanocytic Tumors.
Chang Soo PARK ; Hwan KIM ; Hyang Mi KO ; Kyung Soo KIM ; Ji Shin LEE
Korean Journal of Pathology 1995;29(2):189-196
Immunohistochemical staining on paraffin sections for S-100 protein improved diagnostic accuracy for melanocytic tumor. But specificity of S-100 protein in the diagnosis of melanocytic tumor is very low, because S-100 protein was also expressed in neurogenic tumor and salivary gland tumor. To investigate a specific tumor marker for the malignant melanoma, immunohistochemical staining for HMB-45 and S-100 protein was performed on the paraffin sections of 25 cases of malignant melanoma and 46 cases of nevi. Positive reaction for HMB-45 and S-100 protein was diffusely identified in the cytoplasm of tumor cells. Positive ratio for HMB-45 was 100% in malignant melanoma, 92% in junctional component of compound nevus and 0% in intradermal nevus. Positive ratio for S-100 protein was 92% in malignant melanoma, 100% in compound nevus and 100% in intradermal nevus. The sensitivity and specificity for HMB-45 in malignant melanoma were 100%, but those for S-100 protein were 92% in sensitivity and 86.7% in specificity. These results indicate that HMB-45 has a high sensitivity and specificity for malignant melanoma cells and it can be quite useful for the histopathological diagnosis of malignant melanoma.
Sensitivity and Specificity
;
Tumor Markers, Biological
3.Cytomegalovirus Infection In a Patient with Hypersensitivity Angiitis due to H-S Purpura: A case report.
Ji Shin LEE ; Hyang Mi KO ; Kyung Soo KIM ; Chang Soo PARK ; J Sang Woo UHNG
Korean Journal of Pathology 1995;29(1):119-121
Gastrointestinal cytomegalovirus(CMV) infection in adults is observed as a part of a generalized or localized infection in patients who are immunocompromized. We report a case of CMV infection of the small intestine. The patient is a 34 year-old woman who has complained of palpable purpura in the lower extremities and buttocks, and arthralgia of large joints. The skin biopsy showed fibrinoid necrosis and neutrophils with leukocytoclasis, which findings are compatible with hypersensitivity angiitis. The patient received steroid and cyclophosphamide. During the follow-up period, generalized edema and bloody stool were detected. Resected specimen of small bowel has multiple aphthous ulcer. Microscopically, cytomegalic cells are observed along the endothelial cells and mesenchymal cells. In situ hybridization using DNA probes against CMV revealed positive staining in the cytomegalic inclusions in vascular endothelial and mesenchymal cells.
Adult
;
Male
;
Female
;
Humans
;
Biopsy
4.A Case of Acute Renal Failure due to Bilateral Acute Pyelonephritis.
Kyoung Soo KIM ; Kyu Beck LEE ; Hee Moo LEE ; Kwon CHOI ; Bum Soo KIM ; Hyang KIM ; Sang Jong LEE ; Chan Pil PARK ; Moon Hyang PARK
Korean Journal of Nephrology 1998;17(6):988-993
Although urinary tract infections are common in adults, pyelonephritis is rarely considered in the differential diagnosis of acute renal failure. Acute pyelonephritis without urinary tract obstruction, previous renal diseases or septic shock is a rare cause of acute renal failure. Despite appropriate antibiotic therapy, recovery of renal function could be slow and incomplete. We experienced a 45 year-old woman with diabetes who developed bilateral acute pyelonephritis followed by acute renal failure. The renal biopsy revealed diffuse edematous and focal fibrotic inters- titium with infiltration of lymphocytes compatible with interstitial nephritis. Although her renal function improved gradually with antimicrobial treatment, the process was incomplete and renal dysfunction persisted at about 10-month follow-up, suggesting permanent renal damage. Therefore, we report this case with brief review of related literature.
Acute Kidney Injury*
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Adult
;
Biopsy
;
Diagnosis, Differential
;
Female
;
Follow-Up Studies
;
Humans
;
Lymphocytes
;
Middle Aged
;
Nephritis, Interstitial
;
Pyelonephritis*
;
Shock, Septic
;
Urinary Tract
;
Urinary Tract Infections
5.The Study of Proliferating Cell Nuclear Antigen (PCNA) Reactivity in Fibrohistiocytic Tumors.
Jae Hyuk LEE ; Yong Han PARK ; Hyang Mi KO ; Ji Shin LEE ; Chang Soo PARK
Korean Journal of Pathology 1994;28(4):350-357
Fibrohistiocytic tumors are a diverse group of benign and malignant soft tissue lesions, including dermatofibroma, dermatofibrosarcomaprotuberans, and malignant fibrous histiocytoma. On the clinical point of view, the distinction between benign and malignant lesions and malignancy grading is far more important. Therefore, we investigated 23 fibrohistiocytic tumors, using PCNA (PC10) which was a useful marker of proliferating activity, to differentiate the benign lesions from the malignant and correlate with other prognostic factors including tumor necrosis. cellularity, histologic grade, and mitotic counts. The results obtained were as follows 1) Positive tumor cells were clearly identified by the characteristic diffuse or granular nuclear staining. 2) The number of PCNA-positive tumor cells were 2.16+/-2.39% in dermatofibroma, 16.12+/-7.38% in dermatofibrosacoma protuberans, and 28.02+/-17.47% in the malignant fibrous histiocytoma. The numbers of PCNA-positive tumor cells in the malignant lesions higher than in the benign (p<0.001). 3) Deep seated, large size (>5 cm) and recurred or metastatic cases of MFH were more the high PCNA index (more than 20%) than the low index (less than 20%) groups. 4) PCNA index in MFHs had positive correlation with the number of mitotic counts (r=0.7582, p<0.001), cellularity (r=0.5908, p<0.05) and histologic grade (r=0.4164, p<0.05). These results suggested that reactivity on PCNA might assist in the distinction between benign and malignant lesions in fibrohistiocytic tumors, and could be a useful prognostic factor in the patients with malignant fibrous histiocytoma.
Neoplasm Metastasis
6.A case of ruptured interstitial pregnancy with 19 weeks gestation.
Do Yung CHOI ; Mi Kyung KIM ; Hyang Mi LEE ; Hye Mi LEE ; Sam Soo HO
Korean Journal of Obstetrics and Gynecology 1993;36(1):106-115
No abstract available.
Pregnancy*
7.CT Findings of Bowel and Mesenteric Injury.
Hyung Sik YOO ; Hee Soo KIM ; Myeong Jin KIM ; Jong Tae LEE ; Hyang Mee LEE
Journal of the Korean Radiological Society 1995;33(4):569-574
PURPOSE: To evaluate the role of CT in the diagnosis of bowel and mesenteric injury we studied the CT findings and its usefulness in patients of abdominal trauma. MATERIALS AND METHODS: CT scans of 27 patients who were confirmed to have bowel and/or mesenteric injury due to abdominal trauma were analyzed retrospectively. Of these 27 patients 15 had bowel injury only and 12 had both bowel and mesenteric injury. CT findings analysed were bowel wall thickening, presence or absence of highly attenuated bowel wall, sentinel clot, mesenteric infiltration, peritoneal fluid collection and free intraabdominal air in cases with bowel injury only and with both bowel and mesenteric injury respectively. Ten patients had other accompanying abdominal injuries, such as liver, spleen, pancreas, kidney, bladder injuries, intraperitoneal abscess or retroperitoneal hemorrhage. RESULTS: Findings observed were bowel wall thickening in 23 cases(85%), peritoneal fluid collection in 21 (78%), highly attenuated bowel wall in 19(70%), mesenteric infiltration in 17(63%), free intraperitoneal air in 10 (37%) and sentinel clot in 7(26%). Pneumoperioneum were observed in 10 of 24 patients(41.7%) having bowel perforation. Two cases did not show any CT findings suggesting bowel and/or mesenteric injury. There was no significant difference in the prevalence of the CT findings between the patient group with bowel injury only and the patient group with both bowel and meseneric injury. CONCLUSION: CT scan is a useful tool in evaluating the degree and extent of bowel and/or mesenteric injury as well as in planning the patient's management.
Abdominal Injuries
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Abscess
;
Ascitic Fluid
;
Diagnosis
;
Hemorrhage
;
Humans
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Kidney
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Liver
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Pancreas
;
Prevalence
;
Retrospective Studies
;
Spleen
;
Tomography, X-Ray Computed
;
Urinary Bladder
8.Immunohistochemical and Ultrastructural Studies of Gastric Smooth Muscle Tumor.
Hyang Mi KO ; Kyung Soo KIM ; Jae Hyuk LEE ; Woo Sik JUHNG ; Sang Woo JUHNG
Korean Journal of Pathology 1996;30(3):245-254
To evaluate the differentiation status of smooth muscle in gastric stromal tumors which were negative for S-100 protein, immunohistochemistry using desmin, actin, myosin and vimentin was performed in 14 cases of gastric smooth muscle tumors. Ultrastructural Examination was also performed. For comparison a case of leiomyoma of the esophagus, a case of the sigmoid colon, 10 cases of the uterus were also examined. The results obtained were as follows. All gastric smooth muscle tumors showed vimentin-positivity. Six of 14 gastric smooth muscle tumors, (5 of 8 leiomyoma and 1 of 4 leiomyosarcoma) showed positivity for desmin, actin, and myosin(42.9%). All esophageal, colonic, and uterine leiomyomas showed diffuse positive reaction for desmin, actin, and myosin. Vimentin positivity was also noted in leiomyoma of the colon and uterus. Ultrastructurally, a few cells in the gastric stromal tumors had scattered microfilaments with dense bodies, subplasmalemmal dense plaques, and micropinocytic vesicles. However, most of the tumor cells did not have any of the ultrastructural features of smooth muscle differentiation. Leiomyomas of the esophagus and uterus showed many cytoplasmic microfilaments with dense bodies. These results suggest that most of the benign and malignant tumor cells of gastric stromal tumors have features of the undifferentiated cells, immunohistochemically as well as ultrastructurally, although a few cells have. It is speculated that most gastric stromal tumors may have lost their smooth muscle differentiation.
9.Two cases of conjoined twins.
Mi Kyung KIM ; Hyang Mi LEE ; Do Young CHOI ; Jee Hong PARK ; Sam Soo HO
Korean Journal of Obstetrics and Gynecology 1992;35(11):1673-1678
No abstract available.
Twins, Conjoined*
10.The value of computerized axial tomography of the brain in children with central nervous system disorders.
Young Gyun LEE ; Dae Sung HWANG ; Kwang Soo OH ; Hyang Seuk YOON ; Jong Duck KIM
Journal of the Korean Pediatric Society 1991;34(10):1409-1416
No abstract available.
Brain*
;
Central Nervous System Diseases*
;
Central Nervous System*
;
Child*
;
Humans