1.The Significance of Bone Scan in Trauma in Orthopaedic Field
Han Koo LEE ; Soo Yong LEE ; Soo Ho LEE
The Journal of the Korean Orthopaedic Association 1985;20(1):32-40
Clinical experience with 99mTc-methylenediphosphonate was presented in 115 patients with trauma, who were treated at Seoul University Hospital from Jan. 1980 to Dec. 1983. The results were summarized as followings: 1. Bone scan exhibited increased uptake in all cases examined within 1 year of trauma and the frequency of scan positivity was diminished as the interval between trauma and the scan increased. 2. The possible factors associated with positive scans in cases more than 2 years after trauma were malunion and post-traumatic arthritis, but the age, general condition of the patient were not appeared to be significantly related to persistent positive scan. 3. Bone scan was thought to be sensitive enough to detect early stress fracture ot accompanied by radiographic abnormali ty. 4. It seemed to be reasonable to judge that the fracture was old when the bone scan of vertebral compression fracture in the young age group was negative except very early stage of trauina. 5. Bone scan was very sensitive to find early post-traumatic avascuhr necrosis in femoral neck fracture when the roentgenographic finding was equivocal.
Arthritis
;
Femoral Neck Fractures
;
Fractures, Compression
;
Fractures, Stress
;
Humans
;
Necrosis
;
Seoul
2.Effects of Ischemia on the Specific Activity of Ca++ - Mg++ -Activated ATPase in the Subcellular Fraction of Renal Tissues in Rabbits.
Korean Journal of Urology 1989;30(4):470-480
Calcium has been implicated as a primary pathogenetic mediator of cellular injury under conditions of oxygen and substrate deprivation in the kidney aswell as other tissues. It has been proposed that calcium entry from the external medium increases intracellular free calcium to toxic levels there-by converting cellular injury from a potentially reversible to an irreversible state. Cellular calcium homeostasis is a fundamental prerequisite for many coordinate cellular functions. The regulation of cellular Ca++ -metabolism is maintained mainly by Ca++ -ATPase. The purpose of the present study was to determine the effects of ischemia on the subcellular specific activity of Ca++ -ATPase of renal tissues in the rabbits. 1. In both normal cortical and medullary tissues, the specific activities Ca++ -ATPase were higher in mitochondria than in cytosol. 2. In cortical tissue, the specific activities of mitochondrial Ca++ -ATPase were increased with duration of ischemic time under normothermia. But the specific activities were decreased comparing to those of control under hypothermia, and the activities were not different with those of control in Verapamil treated group. 3. The specific activities of Ca++ -ATPase of cortical cytosol were increased as in mitochondria under normothermia. And the activities were similar with those of control in hypothermic and Verapamil treated groups. 4. In medullary tissues, the specific activities of mitochondrial Ca++ -ATPase were increased with duration of ischemic time under normothermia. In Verapamil treated group, the activities were decreased comparing to those of control. And there was no difference of activities between hypothermia and control groups. 5. As in cortical tissues, the specific activities of Ca++ -ATPase of medullary, cytosol were increased in normothermic group. And the activities were similar with those of control in hypothermic and Verapamil treated groups. Above results suggested that calcium contents of mitochondria and cytosol were increased with duration of ischemic time under normothermia. Hypothermia and Verapamil treatment seemed to be beneficial effects in prevention of calcium accumulation in the renal tissues.
Adenosine Triphosphatases*
;
Calcium
;
Cytosol
;
Homeostasis
;
Hypothermia
;
Ischemia*
;
Kidney
;
Mitochondria
;
Oxygen
;
Rabbits*
;
Subcellular Fractions*
;
Verapamil
3.Clinical Study for drug Eruptions.
Korean Journal of Dermatology 1978;16(5):377-381
The series comprised 424 cutaneous reactions to drugs treated at the department of Dermatology, Medical college of Korea University, during the years 1969-1975. The whole series comprised 211 male(49. 8%) and 213 female(50. 2%) patients. Exanthernatous eruptions are the most frequent of all cutaneous manifestation of drug reactions. Antipyretic analgesics, antibiotics and antibacterial drugs were the three group inducing most drug reactions in the present study, following by herb drugs. Of the antipyretic anaIgesics, acetylsalicylic acid was the ones most of the involved, and sulfonamides were the most frequent cause of skin reactions induced by antibacterial drugs and penicillin and tetracycline were the frequent cause of skin reactions induced by antibiotics.
Analgesics
;
Anti-Bacterial Agents
;
Aspirin
;
Dermatology
;
Drug Eruptions*
;
Humans
;
Korea
;
Penicillins
;
Skin
;
Sulfonamides
;
Tetracycline
4.The Evaluation of Proprientary Topical Corticosteroid Preparations : Vasoconsticitive Assays on Nineteen Creams and Ointments.
Korean Journal of Dermatology 1979;17(3):207-213
No abstract available.
Ointments*
5.Sciatic Nerve Palsy Due to Hematoma Following Anticoagulation Therapy for Prevention of Venous Thromboembolism after Total Hip Arthroplasty - A Case Report -.
Hip & Pelvis 2013;25(1):77-81
Nerve palsy as a complication of hematoma following total hip arthroplasty (THA) is a rare development. Although rare, this complication can cause permanent nerve palsy. The authors experienced a case of recovery from sciatic nerve palsy after emergency evacuation of a hematoma. The expanding thigh hematoma was due to anticoagulation treatment for prevention of venous thromboembolism after total hip arthroplasty. After 10 months from the operation, the patient regained complete motor power and leads an ordinary life. The authors would like to emphasize the danger of hematoma following anticoagulation therapy for prevention of venous thromboembolism after total hip arthroplasty.
Arthroplasty
;
Emergencies
;
Hematoma
;
Hip
;
Humans
;
Paralysis
;
Sciatic Nerve
;
Sciatic Neuropathy
;
Thigh
;
Venous Thromboembolism
6.Allelic Association of the Dopamine D4 Receptor Gene in Korean Alcoholism.
Journal of the Korean Society of Biological Psychiatry 2001;8(2):246-250
The dopamine D4 receptor gene has a hypervariable segment in the coding region charcterized by a varying number of 48bp repeats in exon III of the gene. Varying the numbers of repeated segments may change the length, structure, and function of the receptor, which makes this gene a possible candidate for variations in dopamine-related behaviors. such as alcoholism and drug abuse. We evaluated the dopamine D4 receptor genotype in male alcoholics and normal controls. All alcoholics and controls were unrelated and from the Korean population. Genotype and allele frequencies in 67 alcoholics were compared to 67 controls who were free of alcohol abuse. substance abuse. and major mental illness. No association was found between the dopamin D4 recepto allele and alcoholism. This result indicate that there is no association of the dopamine D4 receptor with alcoholism in Korean. Further systemized investigation to determine the role of dopamine D4 receptor gene in alcoholism with a larger sample size will be required.
Alcoholics
;
Alcoholism*
;
Alleles
;
Clinical Coding
;
Dopamine*
;
Exons
;
Gene Frequency
;
Genotype
;
Humans
;
Male
;
Receptors, Dopamine D4*
;
Sample Size
;
Substance-Related Disorders
7.Mechanisms of HPV-16-induced Transformation in Human Epithelial Cells in Culture.
Heon Soo LEE ; Jae Ho YANG ; Il Soo PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1996;7(4):298-307
Human epithelial cell line immortalized by Ad12-SV40 hybrid virus was transfected with plasmid containing HPV-16 via calcium-phosphate method. Subsequently, 8 clonal cell lines were obtained after G418 selection. Among these clonal cells, clonal cell-4(C-4) and clonal cell-6(G-6) showed increases of tumorigenic cellular properties such as saturation density, soft agar colony formation and cell aggregation. Morphological alteration such as appearane of foci was observed on these two clones after passage 6 and 7(50 to 55 days after transfection). When clonal cells and control cells were treated with MNNG(0.01ug/ml), both C-4 and C-6 showed increases of tumorigenic cellular properties and the level of increase was much more elevated as compared to clonal cells prior to MNNG treatment. Appearance of foci formation was observed in C-4 and C-6 after passage-6. After passage-8, control cells and all clonal cells showed morphological alterations. It seems that treatment of cells containing HPV-16 DNA with MNNG increases tumorigenic properties of the cells and expedite morphological transformations. (continue)
Agar
;
Cell Aggregation
;
Cell Line
;
Clone Cells
;
DNA
;
Epithelial Cells*
;
Human papillomavirus 16
;
Humans*
;
Methylnitronitrosoguanidine
;
Plasmids
8.Expression of CD31, CD34, and Factor VIII-related Antigen in Vascular and Spindle Cell Tumors of the Skin.
Eil Soo LEE ; Ho Su CHUN ; Joung Ho HAN
Annals of Dermatology 1997;9(2):95-101
BACKGROUND: The immunohistochemical detection of endothelial differentiation in skin tumors has been hindered by the relative paucity of reliable markers that are applicable to rou- tinely-processed specimens, which are both specific and sensitive as well. OBJECTIVE: This study was designed to evaluate the utility of CD31 and CD34, newly introduced vascular markers, in the immunohistochemical differentiation of vascular neoplasms from other mesenchymal tumors and to compare their sensitivity and specificity with factor VII-related antigen (FVIIIRA). METHODS: Paraffin-embedded specimens of 26 cases of benign and malignant vascular tumors and 25 cases of non-vascular mesenchymal neoplasms of the skin and subcutis were investigated for CD31, CD34, and FVIIIRA expression using immunohistochemical methods. RESULTS: CD31-immunoreactivity was observed in all of the 26 vascular lesions. CD34 and FVlllRA were labelled in 23 cases and 16 cases of vascular tumors, respectively. All of the 25 non-vascular mesenchymal tumors were negative for CD31 and FVIIIRA. In contrast, positive reactivity for CD34 was seen in 14 cases, among which dermatofibrosarcoma protuberans(2/2), neurofibroma(8/8), neuriilemmoma(2/2), and leiomyoma(2/3) were included. CONCLUSION: Our results indicate that CD31 is a more sensitive and specific vascular marker than CD34 and FVIIIRA. A small panel composed of these three antibodies will constitute a comprehensive and reliable method for identifying tumors of vascular origin.
Antibodies
;
Dermatofibrosarcoma
;
Methods
;
Sensitivity and Specificity
;
Skin*
;
Vascular Neoplasms
;
von Willebrand Factor*
9.A Case of Toxic Epidermal Necrolysis Due to Sulfa Drug.
Byoung Ho LEE ; Joong Ho KIM ; Soo Nam KIM
Korean Journal of Dermatology 1978;16(1):73-77
T.E,N. is characterized by large flaccid bullous eruption that has the appearance of the scalded lesion and has large sheets of the pilling off skin. This 49-year-old female patient was suffered from the erythematous skin lesions on the face and. upper chest since 8 hours after oral administration of sulfa drug for endametritis. These lesions spread to the about 80% of whole body surface, and changes to the characterastic flaccid bullous scalded lesion, within next 24 hours. This patient was treated with a massive systemic corticosteroid and antibiotics and etc,so complete recovery of the lesions were found in three case of T.E.N. due to sulfa drug is presented with brief review of literature.
Administration, Oral
;
Anti-Bacterial Agents
;
Female
;
Humans
;
Middle Aged
;
Skin
;
Stevens-Johnson Syndrome*
;
Thorax
10.A New Classification of Polydactyly and It s Application to the Treatment
Moon Sang CHUNG ; In Ho CHOI ; Soo Ho LEE
The Journal of the Korean Orthopaedic Association 1984;19(1):23-32
No abstract available in English.
Classification
;
Polydactyly