No abstract available.
Endometriosis* ; Female ; Leiomyoma* ; Ovary*

Percutaneous coronary angioplasty is well established therapeutic modality in the management of coronary artery disease. However, the high restenosis rate of 30 to 50% limits its usefulness. The principal mechanism of restenosis, ntimalhyperplasia, is the proliferative response of vessel wall to injury, which consists largely of smooth muscle cells. A large body of animal investigations and a limited number of clinical studies have established the ability of ionizing radiation to reduce neointimal proliferation and restenosis rate significantly. Human studies have been reported that intravascular radiation after first restenosis inhibits a second restenosis. Encouraged by these reports, we are also conducting a double blind, placebo-controlled, randomized trial to evaluate this new therapeutic modality in patients with coronary artery stenosis. The objective of our trial is to determine the safety and efficacy of catheter-based solutional beta emitting radioisotope system in preventing restenosis after angioplasty. This review describes the vascular brachytherapy systems and isotopes that have been utilized in the initial clinical trials performed in this area of post PTCA coronary restenosis. The results of many worldwide ongoing clinical trials will determine whether this new technology will change the future practice of vascular intervention.
Angioplasty* ; Animals ; Brachytherapy ; Coronary Artery Disease ; Coronary Restenosis ; Coronary Stenosis ; Humans ; Isotopes ; Myocytes, Smooth Muscle ; Radiation, Ionizing

No abstract available.
Child* ; Humans

The changes of electroencephalogram(EEG) in patients with dementia are most commonly studied by analyzing power or magnitude in certain traditionally defined frequency bands. However because of the absence of on identified metric which quantifies the complex amount of information, there are many limitations in using such a linear method. According to chaos theory, irregular signals of EEG cal also result from low dimensional deterministic chaos. Chaotic nonlinear dynamics in the EEG can be studied by calculating the correlation dimension. The authors have analyzed EEG epochs from three patients with dementia of Alzheimer type and three matched control subject. The result showed that patients with dementia of Alzheimer type had significantly lower correlation dimension than non-demented controls on 12 channels. Topographic analysis showed that the correlation dimensions were significantly lower in patients with Alzheimer's disease on frontal, temporal, central, and occipital head regions. These results show that brains of patients with dementia with dementia of Alzheimer type have a decreased complexity of electrophysiological behavior. We conclude that the nonlinear analysis such as calculating correlation dimension can be a promising tool for detecting changes in the complexity of brain dynamics.
Alzheimer Disease ; Brain ; Dementia* ; Electroencephalography* ; Head ; Humans ; Nonlinear Dynamics*

From 1989 to 1996, push back palatoplasty, 2-flap palatoplasty and Furlow's palatoplasty were the main procedures of cleft palate repair in our institute. To compare the maxillary growth state of patients in each palatoplasty group, evaluation of dental occlusion and cephalometric analysis were performed in total 50 patients. The results were as follows: 1. Normal control group was composed of 17 children who didn't have cleft lip or cleft palate. Mean values of cephalometric data in the normal control group were 6.19 cm in SN length, 1.17cm in ONA length, 7.29cm in effective maxillary length 53.88degree in SNO angle, and 82.41 degree in SNA angle. 2. Fourteen patients who underwent push-back palatoplasty showed anterior crossbite in all cases. SNO angle and SNA angle were significantly decreased compared to the normal control group, which indicated significant impairment of maxillary growth. 3. In seventeen patients who underwent 2-flap palatoplasty, 7 patients showed anterior crossbite. Cephalometric parameters showed no significant difference compared to the normal control group. 4. Nineteen patients underwent Furlow's palatoplasty. In this group, 3 patients had anterior crossbite. Cephalometric parameters showed no significant difference compared to the normal control group. Although this report was based on data acquired from patients before the age of complete maxillary growth, our results suggested that each palatoplasty would have a different influence on maxillary growth.
Child ; Cleft Lip ; Cleft Palate ; Dental Occlusion ; Facial Bones* ; Humans ; Malocclusion

BACKGROUND: Bupivacaine is a potent, and commonly used, long acting local anesthetic. If accidentally injected into the systemic circulation, bupivacaine can cause lethal dysrhythmias and circulatory collapse. Attempts to treat bupivacaine induced cardiac toxicity have been varied and controversial, and they have not been very successful. The aim of this study was to investigate the electrophysiologic effects of bupivacaine in Purkinje fibers. METHODS: Effects of bupivacaine on the membrane potential were studied in 12 isolated canine Purkinje fibers. Purkinje fibers from ventricle were dissected and mounted in a tissue chamber perfused with Tyrode's solution. Transmembrane potentials recorded through glass microelectrodes filled with 3M KCI in the beating or quiescent Purkinje fibers during infusions of bupivacaine at concentratons of 3*10/-7M,10/-6M, 3*10/-6M,10/-5M, and 3*10/-5M. RESULTS: Bupivacaine reduced action potential druation in a dose-dependent manner. Bupivacaine produced a decrease in intracelullar sodium ion activity in driven(1Hz) and quiescent canine Purkinje fibers. Bupivacaine-induced hyperpolarizaton of diastolic membrane potential in quiescent Purkinje fibers was dose dependent, and the hyperpolarization by bupivacaine was attenuated by depolarization induced by high potassium extracellular concentration in part. CONCLUSIONS: These results suggest that bupivacaine decreases the fast inward sodium current, and inhibits pacemaker current in canine Purkinje fibers.
Action Potentials ; Bupivacaine* ; Glass ; Membrane Potentials* ; Membranes* ; Microelectrodes ; Potassium ; Purkinje Fibers ; Shock ; Sodium ; Sodium Channels

Ameloblastic fibrosarcoma is an extremely rare variety of odontogenic tumor. It has not previously been reported in Korea. The tumor is composed of benign odontogenic epithelium with a mesenchymal part which exhibits the histologic features of fibrosarcoma. We have reported a case of amloblastic fibrosarcoma of the mandible in a 26-year-old man with swelling of right mandible for 2 weeks. The tumor showed yellowish ill-demarcated ulcerating mass involving right premolar and molar area. Light microscopy revealed irregularly arranged strands and islands of odontogenic epithelium surrounded by abundant mesenchymal tissue with the feature of fibrosarcoma. The fibrosarcoma cells were strong positive on immunostain for vimentin and ameloblastic cells were weakly positive for cytokeratin. S-100 and CEA were negative in both epithelial and sarcoma cells. The sarcoma cells were corresponding to fibroblasts on the electron microscopy with abundancy of RER and mitochondria and covering of basal lamina. Two types of virus like particles were distributed in the cytoplasm and nuclei of sarcoma cells. We treated the patient with surgery and chemotherapy. The recovery was uneventful and the prognosis is under observation.
Male ; Humans

BACKGROUND: Pretreatment or addition of lidocaine or ketamine have been reported to reduce pain on injection. However, the stability of propofol following the addition of lidocaine or ketamine is not yet known. Therefore, we checked compatibility and stability of propofol-lidocaine or propofol-ketamine mixtures. METHODS: After mixing 9 ml of 1% propofol and 0, 5, 10, 15, or 20 mg of 2% lidocaine or 10, 20 mg of ketamine, the samples (0.9 ml) were divided into 10 glass vials and stored at room temperature. Macroscopic and microscopic changes, and propofol concentrations were measured at 0, 1/4, 1/2, 1, 2, 3, 4, 5, 6, and 24 hours after mixing. Premedicated 100 ASA classification I or II patients scheduled for elective surgery were randomly allocated into one of three groups(Group 1: propofol only, Group 2: propofol + lidociane 20 mg, Group 3: propofol + ketamine 10 mg). Intensity and frequency of injection pain was checked during induction (150 ml/hr). Intensity of injection pain was evaluated with a pain score (1: no pain, 2: mild, 3: moderate 4: severe). RESULTS: Macroscopic and microscopic changes were only seen in propofol-lidocaine mixtures (more than 15 mg after 1 hour) in a time-dependent manner. In the mixtures with lidocaine 15 or 20 mg, the propofol concentration decreased linearly and significantly compared to the control (time 0) in a time-dependent manner from 1 hour to 24 hours. However, the propofol concentration was not changed in the propofol-ketamine mixtures. The pain score at 20 mg of lidocaine or 10 mg of ketamine were significantly lower than propofol only group and there was no difference in pain score between group 2 and group 3. CONCLUSIONS: Lidocaine (more than 15 mg), but not ketamine, added to 90 mg of propofol reduced the propofol concentration linearly in a time-dependent manner and showed microscopic changes from l hour after mixing. Therefore, this mixture seems to be inappropriate for long-standing storage and thus propofol-ketamine mixtures are more appropriate for this purpose.
Classification ; Glass ; Humans ; Ketamine ; Lidocaine ; Propofol*

The authors observed clinically typical case of unilateral coloboma of the optic disc. This patient, 5 years old Korean boy, visited to our clinic with the chief complaints of visual disturbance and intermittant exotropia of left defecting eye. The optic disc was enlarged about 2.5 times of normal optic disc diameter excavated about 7.0 Diopters in depth. The vision of colombomatous left eye was 20/50(n.c.) but the cause of defective vision was not evaluated certainely whether it might be due to coloboma itself or slight posterior subcapsular opacity of the lens.
Child, Preschool ; Coloboma* ; Exotropia ; Humans ; Male ; Optic Nerve*

PURPOSE: Non-enhanced spiral computed tomography (NESCT) has become the preferred method for imaging urinary calculi. We evaluated the Hounsfield units (HU) of urinary calculi on NESCT as a predictor of the therapeutic effect of extracorporeal shockwave lithotripsy (ESWL). MATERIALS AND METHODS: We evaluated 72 patients with urinary calculi who underwent ESWL. The HUs of calculi were measured on the pretreatment NESCT and at post-treatment via radiographic assessment. The patients were divided into 2 groups, the response group (n=39): the patients with remnant calculi less than 3mm or they were without remnant calculi, and the non-response group (n=33): the patients with remnant calculi greater than 3mm. The HUs of the response and non-response groups were then compared. RESULTS: The HUs of the response and non-response groups were 529.7+/-168.2 and 814+/-116.6, respectively, and the HUs of the non-response group was significantly higher than that of the non-response group. CONCLUSIONS: The HU of urinary calculi, as seen on NESCT, can help to predict the therapeutic effect of ESWL and also select the most effective treatment modalities for the patients suffering with urinary calculi.
Calculi ; Humans ; Lithotripsy* ; Tomography, Spiral Computed ; Urinary Calculi*