1.Clinical Study of Fracture of the Distal Femur in Adult
Dong Soo KIM ; Chang Hee CHUNG
The Journal of the Korean Orthopaedic Association 1973;8(4):428-432
1. 39 cases of fractures of the distal femur treated at the Gwang Ju Triservice Armed Hospital during period from January, 1968 to May, 1973 were subjected to analysis. 2. Most common cause of fracture was traffic accident and supracondylar fractures were most common. 3. Of 39 cases, 22 cases were treated by closed method with or without skeletal traction and 17 cases were treated by open reduction and internal fixation. 4. Closed methods resulted in better funtional recovery after union of fracture. 5. The healing period was 14 weeks in average.
Accidents, Traffic
;
Adult
;
Arm
;
Clinical Study
;
Femur
;
Gwangju
;
Humans
;
Methods
;
Traction
2.A case of cutaneous T cell lymphoma (sezary syndrome).
Chang Hwan LEE ; Seong Hee LIM ; Wang Hee YOO ; Soo Mi CHOI ; Chang Yeol YIM
Korean Journal of Hematology 1993;28(1):171-177
No abstract available.
Lymphoma, T-Cell, Cutaneous*
3.A Case of the Renal Artery Aneurysm Associated with the Dysplastic Kidney.
Tae Hee PARK ; Soo Hee CHANG ; Young Min HAN ; Soo Chul CHO ; Dae Yeol LEE
Journal of the Korean Pediatric Society 1995;38(11):1571-1576
No abstract available.
Aneurysm*
;
Kidney*
;
Renal Artery*
4.A Case of Rapidly Progressive Glomerulonephritis in Henoch-Schonlein Purpura.
Soo Hee CHANG ; Dae Sun JO ; Dae Yeol LEE
Journal of the Korean Society of Pediatric Nephrology 1997;1(1):82-85
A case of primary non-clear-cell adenocarcinoma of the vagina is reported occurring in a 65-year-old woman without exposure to diethylstilbestrol (DES) in utero. The adenocarcinoma did not appear to be associated with vaginal adenosis. It lacked clear cell component and interestingly composed of columnar epithelial cells of endocervical-type. Cytologically round to oval nuclei revealed one or more small nucleoli and fine granular chromatin pattern. Cytoplasm was plump, faintly basophilic and homogeneously stained. Histologically well differentiated columnar epithelial cells were arranged in trabecular pattern mainly, and also occasional glandular lumina and small solid sheets were found. Mitoses were hardly found.
Adenocarcinoma
;
Aged
;
Basophils
;
Cellular Structures
;
Chromatin
;
Cytoplasm
;
Diethylstilbestrol
;
Epithelial Cells
;
Female
;
Glomerulonephritis*
;
Humans
;
Mitosis
;
Purpura, Schoenlein-Henoch*
;
Vagina
5.Clinical Observation of Congenital Urinary Tract Anomalies.
Sun Jun KIM ; Dae Yeol LEE ; Soo Hee CHANG
Journal of the Korean Society of Pediatric Nephrology 1997;1(1):67-72
We present the cytologic features of a case of solid and papillary neoplasm of the pancreas. Cytologically, the tumor was composed of a monotonous population of polygonal cells containing eccentrically located round nuclei with one or two distinct small nucleoli and a finely stippled chromatin pattern. The tumor cells were similar to those of the islet cell tumor and showed isolated loosely aggregated and solid sheets or large cell clumps. The large cell clumps revealed a branching papillary structure containing fibrovascular central core, which is characteristic histologic feature of solid and papillary neoplasm of the pancreas. This case was confirmed by tissue examination including histochemical, immunohistochemical and electron microscopical studies. Ultrastructurally, the tumor cells contained a few membrane-bound electron dense granules.
Adenoma, Islet Cell
;
Chromatin
;
Pancreas
;
Urinary Tract*
6.A Case of Atypical Fibroxanthoma.
Soo Il CHUN ; Hee Yong PARK ; Chang Jo KOH
Korean Journal of Dermatology 1984;22(4):454-458
We described a 65-year-old woman with a papule on the left temple area of } year duration. The lesion showed typical findings of atypical fibroxanthoma and was located on the lesion of solar keratosis, So sunlight may be the most important one among the various insults to atypical fibroxanthoma of the skin.
Aged
;
Female
;
Humans
;
Keratosis
;
Skin
;
Sunlight
7.Restoration of Hormone Dependency in Estrogen Receptor - Lipofected MDA-MB-231 Human Breast Cancer Cells.
Young Jin SUH ; Jae Hee CHANG ; Chung Soo CHUN
Journal of the Korean Cancer Association 1999;31(3):473-482
PURPOSE: The loss of estrogen and progesterone receptors appeats to be associated with a progression to less differentiated and hormone-independent tumors. The gain of hormone independency over time even in estrogen receptor-positive tumors has become another obstacle to endocrine therapy for breast cancer. We tried to regain the hormone dependency in estrogen receptor-negative breast cancer cells by lipofecting estmgen receptor cDNA. MATERIALS AND METHODS: The mutant human estrogen receptor cDNA (pSGS-HEO) was lipofected into estrogen receptor-negative human breast cancer cell line MDA-MB-231, in an attempt to restore their sensitivity to antiestrogen. Then the effects of 17p-estradiol and tamoxifen were studied by counting viable cell numbers after treating the lipofected cell line with either one or together. RESULTS: Culture medium cantaining phenol red, a weak estrogen, has growth advantages compared with culture medium without it. In both culture conditions, cell growth was most profoundly inhibited in 4 days after lipofection with mutant human estrogen receptor cDNA, which was overcome after that day. Tamoxifen, as an antiestrogen, showed a growth inhibitory effect slightly stronger tban combined conditions of tamoxifen and 17- estradiol compared to estrogen-treated group and to control, and the inhibitory effect was lasted 4 days. CONCLUSION: The temporary induction of estrogen receptor by lipofection with pSGS-HEO on estrogen receptor-negative human breast cancer cell line MDA-MB-231 showed negative growth control on these cells by tamoxifen, indicating that liposome-mediated estrogen receptor transfection may be used as a novel therapeutic strategy for hormane independent human breast cancers in the near future.
Breast Neoplasms*
;
Breast*
;
Cell Count
;
Cell Line
;
DNA, Complementary
;
Estradiol
;
Estrogen Receptor Modulators
;
Estrogens*
;
Genetic Therapy
;
Humans*
;
Phenolsulfonphthalein
;
Receptors, Progesterone
;
Tamoxifen
;
Transfection
8.Expression of Proliferating Cell Nuclear Antigen and p53 Protein in Ovarian Epithelial Tumors.
Jong Jae JUNG ; Jong Hee NAHM ; Chang Soo PARK
Korean Journal of Pathology 1998;32(3):193-200
p53 gene mutation is commonly accepted to be associated with loss of negative cell cycle control and progression of tumors. The proliferative activity of tumor cells is considered to be a valuable indicator of tumor aggressiveness. This study is intended to compare p53 protein expression with cell proliferation rates in the ovarian epithelial tumors according to the various clinicopathological parameters. Immunohistochemistry using monoclonal p53 antibody (DO-1) and PCNA antibody (PC10) was applied to 56 cases of ovarian epithelial tumors including 17 cases of borderline tumor. The results were as follows. Both immunohistochemical staining of PCNA and p53 protein showed positive reactions confined to the nuclei of tumor cells. There were significant differences of p53 protein expression rates between borderline malignancies (11.8%) and cystadenocarcinomas (56.4%) of ovary. The expression rate of p53 protein was not significantly different according to the differentiation and the stage, but the cases of strong positive reaction to p53 protein were more frequently noted in the poorly differentiated and advanced staged tumors. The PCNA indices of p53 strong positive cases were higher than those of p53 weak positive cases. In summary, p53 protein and PCNA expression may be used as an adjuvant in differentiating borderline lesions from carcinomas of ovary and predicting their biological behaviors.
Cell Cycle Checkpoints
;
Cell Proliferation
;
Cystadenocarcinoma
;
Female
;
Genes, p53
;
Immunohistochemistry
;
Ovary
;
Proliferating Cell Nuclear Antigen*
9.Therapeutic Effect of Iron Deficiency Anemia.
Dong Suk LEE ; Chang Hee HAN ; Kun Soo LEE
Journal of the Korean Pediatric Society 1990;33(6):799-806
No abstract available.
Anemia, Iron-Deficiency*
;
Iron*
10.Clinical Status of Apnea in Prematurity.
Soon Hee KIM ; Chang Soo RA ; Keun LEE
Journal of the Korean Pediatric Society 1986;29(7):60-66
No abstract available.
Apnea*