No abstract available.
Ambulatory Care Facilities* ; Humans ; Outpatients*

BACKGROUND: Cyclic flow variations(CFVs) is defined as morphological evidence of wide flow velocity variations in the Doppler signals due rapid spontaneous changes showing cyclic reduction and abrupt reperfusion of blood flow velocity seen in the critically stenotic arteries. Since first development of the CFVs model using dog by Folts and Uchida, it has been widely used as exellent experiemental model for study of the Acute ischemic heart disease syndrome including unstable angina. Nowadays it has been well documented that these CFVs are closely associated with temporal platelet aggregation and followed thrombus formation at the stenotic arterial lesion with endothelial or medial injury and subsequent release of various chemical mediators, eg. thromboxan A2 and serotonin. Also the CFVs can be seen in some patients of coronary artery stenosis during underwent PTCA, femoral artery stenosis and carotid or cerebral artery stenosis as well as in animal models. Moreover, CFVs has been thought to be the natural preconditioning in the unstable angina. METHODS: We tried to make the CFVs model using left anterior descending coronary artery (LAD) in 6 dogs. Pericardial cradle was made through 5th intercostal thoracotomy. The LAD was isolated carefully and critically stenosed by plastic constrictor and Doppler velocimeter probe was placed under the constrictor. After then intimal and medial layer of the LAD was damaged by a forcep. After appearing of CFVs, we observed and recorded for an hour. Myeloperoxide(MPO) activity in the ischemic and non-ischemic area of the myocardium were studied and compared after sacrifice. RESULTS: CFVs was found in all 6 dogs within an hour. The mean frequency of the CFVs was 9.8+/-4.45 times/hour. The mean coronary blood flow was 5.7+/-2.7 ml/min. And MPO activity was 1.47+/-0.5 units/g tissue in the ischemic myocardium and 0.49+/-0.27 units/g tissue in the non-ischemic area with statistical significance(p<0.005). CONCLUSIONS: CFVs model using various animal models and arterial sites can widely provide usefulness to document pathophysiology and pharmacologic mechanism in human acute ischemic heart disease syndromes.
Angina, Unstable ; Animals ; Arteries ; Blood Flow Velocity ; Cerebral Arteries ; Constriction, Pathologic ; Coronary Stenosis ; Coronary Vessels* ; Dogs ; Femoral Artery ; Humans ; Models, Animal ; Models, Theoretical* ; Myocardial Ischemia* ; Myocardium ; Plastics ; Platelet Aggregation ; Reperfusion ; Serotonin ; Surgical Instruments ; Thoracotomy ; Thrombosis

No abstract available.
Animals ; Antibodies* ; Antibodies, Anticardiolipin ; beta 2-Glycoprotein I* ; Mice* ; T-Lymphocytes, Helper-Inducer*

No abstract available.
Brain Death* ; Brain*

The upper 8 centimeters of the great saphenous vein were studied on 102 sides (84male, 18 female) of adult Chinese cadavers. The chief results were as follows: 1. The surface projection of the sapheno-femoral junction is variable. It lies at avariable distance below the point which is situated opposite the junction of the lateraltwo thirds and medial third of the line joining the anterior superior iliac spine to thepubic tubercle. The mean value of the distance between this point and the sapheno-femoral junction is 3.84?0.07 cm (min. 2.1 cm, max. 5.5 cm). 2. Duplication of the great saphenous vein is rare. It is found on 6 sides only(5.88?2.33%) in our material. 3. There is a close relation between the terminal part of the great saphenous veinand the superficial external pudendal artery. In 65.63?4.85% of the cases, this arterypasses behind the terminal part of the vein. 4. The upper part of the great saphenous vein is joined by lateral, medial, or bothaccessory saphenous veins in 86 sides (84.31?3.60%), among which the lateral accessorysaphenous vein occurs most frequently (61.61?5.24%). 5. The junction between the deep external pudendal vein and the great saphenousvein lies within the fossa ovalies in 25 sides (24.51?4.26%). 6. The patterns of the tributaries of the great saphenous vein may be classifiedinto 4 types and 11 subtypes, according to the number of veins and the manner of theircombination. Type II_2, in which two tributaries are combined, occurs more often thanany other types (38.23?4.81%). In the point of view of practical application, the pat-terns of the tributaries may be classified into different types, according to the numberof the direct opening on the upper part of the great saphenous vein, among which the3 tributary and 4 tributary types are the highest in percentage, being 34.31?4.70% and33.33?4.67% respectively. 7. The position of the tributaries which open into the upper part of the greatsaphenous vein is variable. In the majority of sides (91.18?2.80%), the position lieswithin the uppermost 4 centimeters of the great saphenous vein (min. 0.3 cm, max.7.2 cm). The surgical significance is briefly discussed.

No abstract available.

This study was conducted to identify the factors related to the blood pressure in school children. The study subjects were 144 boys and 140 girls aged 10 years old, 4th grade student of one elementary school in Taegu City. Blood pressure and 18 variables for 284 school children were measured in May 1992. A weight-for-height index, Rohrer index(weightlheighe) was calculated for each individual as a measure of obesity. Body fat percent, fat weight, and lean body mass were measured by impedance fat meter(Model SIF-891). Serum total cholesterol, higli-density lipoprotein, triglyceride, uric acid, total protein, and electrolyte were measured by automated clinical chemistry analyzer(Hitachi 4020). Low-density lipoprotein and atherogenic index were calculated by the equation. The variables assessed were sex, systolic blood pressure, diastolic blood pressure, Rohrer index, body fat percent, body fat weight, lean body mass, total cholesterol, high-density lipoprotein, low-density lipoprotein, uric acid, total protein, serum electrolyte and blood glucose. The mean systolic and diastolic blood pressures for boys were 104.1mmHg and 66.6mmHg and those for girls were 102.9mmHg and 67.5mmHg. Systolic blood pressure of boys was positively correlated with height, weight, Rohrer index, fat weight, lean body mass, and triglyceride. Systolic blood pressure of girls was positively correlated with height, weight, lean body mass, and uric acid. Diastolic blood pressure of boys was positively correlated with weight, Rohrer index, and lean body mass. Diastolic blood pressure of girls was positively correlated with height, weight, fat weight, and lean body mass and negatively with total serum protein. In multiple regression analysis for the systolic blood pressure, the significant independent variables were Rohrer index and serum sodium in boys, and serum uric acid, fat percent, and Rohrer index in girls. In multiple regression analysis of the diastolic blood pressure, the significant independent variables were Rohrer index in boys and total serum protein in girls. This study indicated that important factors influencing blood pressure in school children were Rohrer index, fat percent, serum sodium, uric acid, and total protein. Rohrer index was most important among these. It is recommended to enforce the nutritional education for diet control of obesity to prevent hypertention in children and to adopt healthy life-styles that promote good health and prevent development of cardiovascular risk factors.
Adipose Tissue ; Blood Glucose ; Blood Pressure* ; Chemistry, Clinical ; Child* ; Cholesterol ; Daegu ; Diet ; Education ; Electric Impedance ; Female ; Humans ; Lipoproteins ; Obesity ; Risk Factors* ; Sodium ; Triglycerides ; Uric Acid

No abstract available.
Complement System Proteins* ; Humans ; Infant, Newborn*

A study was made on 1,302 cases of skin tumors which were obtained mainly from surgical pathology specimen during the period of 14 years from 1973 to 1986 at Department of Dermatology in Korea University Hospital. The results were summarized as follows : 1. Of the 1,302 cases of skin tumors, 1,143 cases(87.8%) were benigh tumor, 159 cases(12.2%) of malignant tumor and male to female ratio was 1.1: l. 2. Among the 1,143 cases of benign tumors, 301 cases of epidermal cyst, 183 cases of lipoma, 173 cases of pigmented nevi and 88 cases of hemangioma were noted. 3. Among the 159 cases of malignant tumors, 46 cases of squamous cell carcinoma, 27 cases of basal cell carcinoma, 26 cases of malignant melanoma, and 17 cases of metastatic carcinoma were observed. 4. The sites of predilection of the epidermal cysts were trunk (21.9%), face (20.9%), and neck (13.9%) and lipoma was trunk (48.6%). The sites of predilection of the suamous cell carcinomas were penis (11.1%), sclap (12.9%), face (18.5%), and leg (11.1%), basal cell carcinoma was face (55.6%) and malignant melanoma was sole (26.9%). 5. Among the 17 cases of cutaneous metastatic cancer, primary sites were breast (4 cases), pancreas (1 cases), lung (2 cases), stomach (1 cases) and unkown sites (9 cases).
Breast ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Dermatology ; Epidermal Cyst ; Female ; Hemangioma ; Humans ; Korea ; Leg ; Lipoma ; Lung ; Male ; Melanoma ; Neck ; Nevus, Pigmented ; Pancreas ; Pathology, Surgical ; Penis ; Skin* ; Stomach

No abstract available.