Objective To explore the relationship between levels of plasma homocysteine (Hcy) and adrenomedullin (ADM) and sudden sensorineural hearing loss (SSHL) in elderly patients. Methods The 80 patients with SSHL but without any treatment were selected as SSHL group, while 80 age-and sex-matched subjects without SSHL were collected as the control group. The levels of plasma Hcy and ADM were measured by fluorescence method and radioimmunoassay, respectively. And the levels of plasma Hey, ADM, total cholesterol (TC) and triglyceride (TG) were compared between the two groups. Results The levels of plasma Hcy, ADM, TC and TG were significantly higher in SSHL group than in control group [(13. 81±2.88) μmol/L vs. (11. 58±2. 80)/xmol/L, (26. 40±3. 20)ng/L vs. (22. 45±2. 80)ng/L, (5.22±0. 87)mmol/L vs. (4. 52±0. 81)mmol/L, (1.80 ±0. 12)mmol/L vs. (1.52±0. 13)mmol/L;t=5. 03, 8. 22, 7.48, 3. 85, all P<0. 01). When the two groups with hypertension were compared, the levels of plasma Hey, ADM, TC and TG were (15.30±2. 77)μmol/L, (29.40±2. 80) ng/L, (5. 48±0. 98) mmol/L and (1.92±0. 18) mmol/L in SSHL group, which were higher than those in control group[(12. 80±2. 62) μmol/L, (25.20± 2. 60) ng/L, (5.01±1.03) retool/L, (1.62±0. 15) mmol/L3 (t=4.03, 7.01, 3.25, 7. 80, all P< 0. 01). There were no differences in systolic and diastolic blood pressure between the two groups(t= 0. 87, 0. 64;P=0. 38, 0. 55).Conclusions The changes of plasma levels of Hey and ADM in the elderly suggest that they could involve in the pathogenic process of SSHL, which may provide referential value for understanding the state of the disease and judging the prognosis

AIM: To improve the quality, efficiency, standardization and prospective management of ethical review of drug clinical trials in our hospital through the information system construction of ethical review of drug clinical trials. METHODS: The entire information system was designed based on the cloud architecture, enabling all ethics review applicants and ethics committees to use the same system for online registration and online business, which provided an information solution for the business model of regional ethics committees and multi-center ethics mutual recognition. RESULTS: Through the construction of ethical review platform of cloud architecture, the paperless and electronic management of ethical data have been realized, and online meeting review, tracking review and remote video conference have been realized on mobile and computer terminals. CONCLUSION: The information construction of ethical review system improves the efficiency and management level of ethical review in drug clinical trials.