1.Study on CT findings of gastric stromal tumors
Jianbo GAO ; Xuehua YANG ; Yong SUN ; Zhigang ZHOU ; Hua GUO ; Songwei YUE ; Yonggao ZHANG ; Meng GUO
Chinese Journal of Radiology 2008;42(12):1283-1286
Objective To investigate CT findings in gastric stromal tumors(GST).Methods Both plain and enhanced spiral CT findings in 46 cases with gastric stromal tumor were retrospectively analyzed.In all patients,diagnosis was confirmed with immunohistochemical markers.CT features were retrospectively studied and summarized.Statistical analysis of the shape,growth pattern,necrosis and enhancement patterns was performed with X2 test in 43 cases with single gastric stromal tumor.Results Of the 46 GST patients,43 patients had single GST and multiple GST was detected in 3 cases.In the 43 cases with single GST,tumors were found in the gastric body in 24 cases,gastric fundus in 16 cases,and in the gastric antrum in 3 cases.GST mostly grow along the vertical plane of gastric wall,with a large size but local attachment.The tumor size was less than 5era in diameter in 14 cases.Of them,ten cases had a regular shape,10 cases showed homogeneous enhancement,and 4 cases exhibited central necrosis,7 tumors showed intra-luminal growth and 5 tumors showed extra-luminal growth,while the other 2 cases involved both intra and extra lumina.Twenty-nine cases had tumors larger than 5cm in diameter.Of them,24 cases had irregular shape,27 cases showed inhomogeneous enhancement,24 cases had central necrosis,5 tumors showed intra-luminal growth and 9 tumors showed extra-luminal growth,while 15 cases involved both intra and extra lumina.The tumor size of GST closely was related to the shape,growth pattern,necrosis and the inhomogeneous enhancement patterns of the GST(P<0.05).The enhancement of the tumor was more intense in venous phase and delayed phase.Five cases showed septal enhancement,4 tumors exhibited marked enhancement in arterial phase with up to 60 HU.Conclusions CT can precisely display the location,shape and size of gastric stromal tumors.It is very helpful to provide useful information for early diagnosis and evaluation.
2.Diagnosis and differential diagnosis of ovarian thecoma-fibroma in multi-slice CT
Zhixu ZHANG ; Jianbo GAO ; Hua GUO ; Zhigang ZHOU ; Yonggao ZHANG ; Songwei YUE
Journal of Practical Radiology 2015;(9):1483-1486
Objective To analyze the imaging features of ovarian thecoma-fibroma in multi-slice CT (MSCT )and improve the di-agnostic level.Methods CT features of 26 patients with 28 pathologically confirmed lesions were analyzed retrospectively.Correla-tion between tumor length and ascites and menopause was analyzed.Results Of 26 patients (28 lesions),24 patients were unilateral, 2 patients were bilateral.Of 28 lesions,there were 18 ovarian thecoma,6 fibrothecoma and 4 fibroma.The longest diameter of tumor ranged from 34.74 mm to 227.64 mm (mean value 101.06 mm±42.25 mm).The longest diameter of tumor in the group of ascites (n=1 7)was larger than that of without ascites.All the tumors had well-defined border,with 24 of them round or oval in shape,4 lobulated;with 22 of them solid in composition,4 mixed,2 cystic;with 20 of them inhomogeneous in density.The tumors showed no or mild enhancement,0-5 HU added CT value in 1 1,5-10 HU in 1 1,10 -20 HU in 6,with 4 cases showing multiple slim blood vessels during the arterial phase.Conclusion The typical imaging features of ovarian thecoma-fibroma were unilateral,oval,solid mass with well-defined border,no or mild enhancement (less than 20 HU)and accompanied by ascites.These characteristics will be helpful in the diagnosis and differential diagnosis of ovarian thecoma-fibroma.
3.Clinical significance of expression of serum cystatin C in patients with acute leukemia
Jingyong ZHOU ; Juan WANG ; Hua TANG ; Songwei ZHOU ; Zefa LIU
Journal of Leukemia & Lymphoma 2018;27(9):521-524
Objective To study the clinical significance of serum cystatin C (Cys C) in patients with acute leukemia (AL). Methods A total of 59 newly diagnosed AL patients in Xinghua City People's Hospital from January 2014 to August 2017 were enrolled; meanwhile, 59 healthy individuals who underwent physical examination at Medical Center of Xinghua City People's Hospital were selected as the control group. AU5800 automatic biochemical analyzer from American Beckman Coulter Corporation was applied to detect the levels of serum Cys C, lactate dehydrogenase (LDH) and creatinine (Cr). The receiver operating characteristic (ROC) curve was also drawn. Results The levels of serum Cys C and LDH in AL patients were higher than those in the control group [serum Cys C: (1.36±0.72) mg/L vs. (0.76±0.27) mg/L; LDH: (456±362) U/L vs. (185±29) U/L], and there was a statistical significance (t=-5.965, P=0.000; t=-5.718, P=0.000). There was no statistical difference in the serum Cr between AL patients and control group [(86±26) μmol/L vs. (82±16) μmol/L] (P> 0.05). There was a positive correlation between levels of serum Cys C and LDH in AL patients (rs= 0.447, P < 0.05). The ROC area under curve of serum Cys C was 0.823, the standard error was 0.037, and the confidence interval of 95 % was 0.751-0.896. The ROC area under curve of serum LDH was 0.811, the standard error was 0.042, and the confidence interval of 95 % was 0.728-0.894. Conclusion The level of serum Cys C in AL patients is higher than that in the healthy population. The detection of serum Cys C is helpful in the diagnosis of AL and the evaluation of tumor burden, which is consistent with serum LDH.