1.Prevention of acute renal failure in obstructive jaundice patients in perioperative period
Dong DAI ; Xiaoyu TAN ; Xiancheng ZENG ; Songtao DU
Chinese Journal of General Surgery 2001;0(08):-
ObjectiveTo investigate the protection of renal function and the prevention of acute renal failue(ARF) in perioperative period in obstructive jaundice(OJ) patients. Methods In experimantal group, short time parenteral nutrition(PN) was given preoperatirely.Small dosage of dopamine was intravenously dripped.and rapid infusion of 20% mannitol periodically was done.In control group routine treatment was done. Postoperative blood BUN and Cr dynamic changes were examined and occurrence rate of ARF were recorded. Results No ARF occurred in the experimental group;but ARF occurred in 5 cases(29.4%)and 2 cases(17.6%) died (P
2.Combined intravenous and intrathecal vancomycin in treatment of patients with intracranial infections after craniotomy
Yun BAO ; Binghui QIU ; Hao ZENG ; Yiping MO ; Nannan ZHANG ; Songtao QI
Chinese Critical Care Medicine 2016;(2):169-172
Objective To explore the efficacy and safety of combined intravenous and intrathecal vancomycin in treatment of patients with intracranial infection after craniotomy. Methods Clinical data of a total of 60 consecutive patients with intracranial infections after cranial operation admitted to Department of Neurosurgery of Nanfang Hospital of Southern Medical University from June 1st 2013 to June 1st 2015 were retrospectively analyzed. The patients were divided into two groups: intravenous injection only (n = 25) and combined intravenous and intrathecal injection (n = 35). In both groups of patients intravenously given vancomycin hydrochloride 500 kU every 6 hours as well as third or fourth generation of cephalosporins or meropenem. In combined intravenous and intrathecal injection group, in addition to 20 mg vancomycin was slowly injected via lumbar puncture after release of cerebrospinal fluid (CSF) once a day. The clinical efficacy and complications of the two groups were compared. Results The recovery rate in the combined intravenous and intrathecal injection group was significantly higher than that in the intravenous injection only group (94.3% vs. 76.0%, χ2 = 4.220, P = 0.040). Lowering of white blood cell count in combined intravenous and intrathecal injection group was significantly earlier than that of the intravenous injection only group (time to become normal: 8 days vs. 13 days). The time of recovery in combined intravenous and intrathecal injection group was significantly shorter than that of the intravenous injection only group (days: 9.9±0.7 vs. 13.4±1.1, t = -2.716, P = 0.009). There were 3 patients who experienced nerve root irritation symptoms in combined intravenous and intrathecal injection group. Symptomatic treatment was given and injection speed was slowed down for these patients. There were no severe complications, such as coma, epilepsy or death in both groups. Conclusion Combined intravenous and intrathecal injection of vancomycin could be a safe and effective therapy for intracranial infection after craniotomy.
3.Clinicopathological analysis of intestinal polypoid lymphoma in children: report of 15 cases
Hui HUANG ; Wenping YANG ; Songtao ZENG ; Hongyan XU ; Yan WU ; Qingqiang DENG ; Feng XIONG
Journal of Leukemia & Lymphoma 2017;26(8):475-477
Objective To investigate the clinicopathologic features of intestinal polypoid lymphoma (PL) in children. Methods The clinicopathologic data of 15 cases of pediatric intestinal PL in Jiangxi Provincial Children 's Hospital were retrospectively analyzed. Immuohistochemistry was used to detect the expressions of CD10, bcl-6, bcl-2, MUMl and ERCC1, then EB virus (EBV)-encoded RNA (EBER) status was tested by using in situ hybridization. Results Amongst 15 cases studied, 13 cases were Burkitt lymphoma (BL), 1 case was diffuse large B-cell lymphoma (DLBCL) and 1 case was between DLBCL and BL (DLBCL/BL). The positive rate of CD10, bcl-6, bcl-2, MUMl, ERCC1 and EBER were 100.0%(13/13), 92.3%(12/13), 0, 7.7 % (1/13), 15.4 % (2/13), 53.8 % (7/13), respectively in 13 BL cases. The clinical stage of 13 patients with BL: 11 cases (84.6 %) Ⅱ stage, 1 case (7.7 %) Ⅲ stage, 1 case (7.7 %) Ⅳstage. The clinical stage of DLBCL and BL/DLBCL: Ⅱstage. 14 cases of PL had survival time without tumors, 24-120 months follow-up, and 1 BL patient inⅣstage without chemotherapy died after 2 months. Conclusion BL is a major subtype of intestinal PL in children, which shows a low clinical stage and a good prognosis.
4.Solitary infantile choriocarcinoma of liver: report of a case.
Wenping YANG ; Yan WU ; Shouhua ZHANG ; Jinshi HUANG ; Songtao ZENG ; Hua ZENG ; Hui HUANG
Chinese Journal of Pathology 2015;44(9):673-674
5.Pathologic diagnosis of malignant rhabdoid tumor of skin.
Hui HUANG ; Hongyan XU ; Songtao ZENG ; Wenping YANG ; Jinshi HUANG ; Yan WU ; Feng XIONG ; Hua ZENG
Chinese Journal of Pathology 2014;43(5):334-335
Chromosomal Proteins, Non-Histone
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metabolism
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DNA-Binding Proteins
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metabolism
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Diagnosis, Differential
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Follow-Up Studies
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Humans
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Infant
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Infant, Newborn
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Keratins
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metabolism
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Male
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Mucin-1
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metabolism
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Phosphopyruvate Hydratase
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metabolism
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Rhabdoid Tumor
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metabolism
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pathology
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surgery
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Rhabdomyosarcoma
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metabolism
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pathology
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S100 Proteins
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metabolism
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SMARCB1 Protein
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Sarcoma
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metabolism
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pathology
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Sarcoma, Clear Cell
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metabolism
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pathology
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Skin Neoplasms
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metabolism
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pathology
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surgery
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Transcription Factors
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metabolism
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Vimentin
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metabolism
6.Comparison of effects of early and late bone marrow mononuclear cells transplantation on left ventricular remodeling after acute myocardial infarction in swines
Jianping ZENG ; He HUANG ; Zhisan SUN ; Songtao KANG ; Xianghong PENG ; Mingxing WU ; Liyuan WU ; Jianping SUN ; Zhiliu PENG ; Ying LIU ; Wenyan YI
Journal of Chinese Physician 2011;13(11):1493-1496
ObjectiveTo compare the effects on left ventricular remodeling of bone marrow mononuclear cells transplantation one week and three months after acute myocardial infarction.MethodsAcute myocardial infarction models were successfully established in 15 swine,which were randomly divided into three groups:placebo group,early transplantation group and late trasplantation group.One week after model had been established,early transplantation group underwent bone marrow mononuclear cells transplantation,and then so did the late trasplantation group three months after acute myocardial infarction.B-ultrasound and single photon emission computed tomography (SPECT) examinations were performed to assess the left ventricular end diastolic dimension( LVd),left ventricular end diastolic volume(EDV) and left ventricular ejection fraction(EF) before and one week,three months,six months after acute myocardial infarction.ResultsThe LVd of late transplantation group [ (54.20:t:3.70) mm] was lower than placebo group [ (63.20 ±5.63)mm],but higher than early transplantation group [ (47.40 ± 1.14)mm].The EDV of late transplantation group [ ( 163.00 ±6.96)ml] was lower than placebo group [ (209.40 ± 18.69)ml],but higher than early transplantation group [ ( 135.40 ± 4.93 ) ml ].The EF of late transplantation group (0.25 ±0.02) was higher than placebo group (0.19 ±0.02),but lower than early transplantation group (0.37 ±0.02).ConclusionsBone marrow mononuclear cells transplantation can alleviate progressing ventricular remodeling,even it is performed three month after acute myocardial infarction,but its therapeutic effects are inferior to early transplantation's.
7.Establishment of LINC01018 overexpression colon cancer cell line and study on its biological characteristics
Hongwei CHEN ; Jiahong CAI ; Xiaochen ZENG ; Bingjie PAN ; Zhoujing LIU ; Songtao CHEN
Journal of Chinese Physician 2021;23(11):1663-1667
Objective:To establish a colon cancer cell line which overexpressing LINC01018 stably and study its biological characteristics.Methods:The expression of LINC01018 in HCoEpiC and HT-29 cells were detected by real time fluorescence quantitative polymerase chain reaction (qRT-PCR). HT-29 cells were infected with LINC01018 overexpression lentivirus to screen and establish HT-29 cell lines which overexpressing LINC01018 stably. The effect of LINC01018 on the proliferation, invasion and migration of HT-29 cells were detected by cell counting kit-8 (CCK-8) assay and Transwell assay separately. The expression of CDK6 and matrix metalloproteinase-2 (MMP-2) in HT-29 cells was detected by Western blot.Results:The expression of LINC01018 in HT-29 cells was significantly lower than that in the human colonic epithelial cells (HCoEpiC). HT-29-L18 cell lines which overexpressing LINC01018 stably was screened successfully. Overexpression of LINC01018 significantly inhibited the cell proliferation, invasion and migration, and reduced the protein expression of CDK6 and MMP-2 in HT-29 cells.Conclusions:The expression of LINC01018 was decreased abnormally in colon cancer cells. Up-regulation of LINC01018 expression can inhibit the proliferation, invasion and migration of colon cancer cells, which may be related to CDK6 and MMP-2.
8.Research progress of medication-related patient-reported outcome scales
Panpan LU ; Haixin LI ; Zhiling DENG ; Xujian LIANG ; Yiting LU ; Ming YAN ; Songtao CAI ; Wanchao LI ; Ruifeng ZENG ; Yi GUO ; Zhijie XU
Chinese Journal of Pharmacoepidemiology 2024;33(1):95-105
Drug therapy is a common method to cure diseases and relieve symptoms.The value of patient-reported outcome(PRO)in evaluating the effect of drug therapy has been increasingly paid attention.The PRO scale is a standardized questionnaire,which can scientifically evaluate the experiences and subjective effects of drug use from a patient-centered perspective,and help patients and clinicians make more reasonable medication decisions.By reviewing and sorting out relevant global literature,this paper found that the content of the PRO scales relevant to drug therapy focused on five fields:"medication satisfaction""medication adherence""drug treatment burden""medication-related quality of life"and"adverse drug reactions".This paper described the basic information,measurement characteristics and application of common scales in recent years respectively,and summarized and analyzed the problems and enlightenment of scale development,aiming to provide theoretical reference for the selection,application and development of PRO scales.
9.Clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma in children.
Wenping YANG ; E-mail: YWP07912000@163.COM. ; Hongyan XU ; Songtao ZENG ; Ronghua FU ; Hua ZENG ; Meijun TAN ; Yan WU ; Feng XIONG ; Hui HUANG ; Meihui ZHONG ; Shouhua ZHANG ; Junlin ZHOU
Chinese Journal of Pathology 2015;44(7):495-498
OBJECTIVETo investigate the clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma (NICH) in children.
METHODSThe clinical, morphologic and immunophenotypic characteristics of 22 cases of NICH were retrospectively analyzed.
RESULTSThe mean patients' age at diagnosis was 4.2 years, with a male to female ratio of 1.75:1. The tumors were located in the head and face (5 cases), neck (3 cases), body (6 cases), upper limbs (5 cases), and lower limbs (3 cases). Histologically, the tumor was dominated by rather large lobules of small vessels that were mostly rounded, curved, small and thin-walled, and were lined by endothelial cells surrounded by one or more layers of pericytes. The center of the lobules was occupied by one or more thin or thick walled vessels, which were surrounded by fibrous and fatty tissue, which contained abnormal arterial and venous structures. At the edge of the lobules there were lymphatic vessels. Immunohsitochemical study showed that tumor cells in NICH were positive for CD34 (22/22), CD31 (22/22), SMA (22/22), vimentin (22/22) and Glut1 (0/22). D2-40 expression was located at the edge of the capillary lobules.
CONCLUSIONSNICH is a benign lesion. Clinically and pathologically, it needs to be differentiated from rapidly involuting congenital hemangioma, infantile hemangiomas, tufted angioma, vascular malformation, and others.
Biomarkers, Tumor ; Child, Preschool ; Diagnosis, Differential ; Female ; Hemangioma, Capillary ; congenital ; diagnosis ; Humans ; Male ; Retrospective Studies
10.A case report of childhood acute lymphoblastic leukemia with intrachromosomal amplification of AML1 gene in chromosome 21 and TEL deletion.
Wenping YANG ; Feng XIONG ; Hui HUANG ; Yan WU ; Yuanyuan LIN ; Xiaoju FAN ; Zhiqiang LIU ; Xiaozhen ZHANG ; Hongyan XU ; Hua ZENG ; Songtao ZENG
Chinese Journal of Hematology 2015;36(7):569-569