Objective: To investigate the clinical safety and efficacy of ultrapercutaneous nephrolithotomy combined with ureteroscopy in the treatment of severe urete. Methods: Thirty-six patients (20 males, 16 female) with ureteral obstruction underwent super-mini percutaneous nephroscope combined with flexible ureteroscope balloon dilation of 36 patients, 18 ureteral strictures occurred secondary to ureteroscope lithotripsy, 12 secondary to laparooscopic ureterolithotomy, 6 secondary to ureteral end to end anastomosis and one secondary to bladder ureter reimplantation. Results: All of the surgeries were successful. Mean operation time was 60 min, the hospital stay was 2 to 7 days, and mean bleeding volume was 43 ml. No patients suffered fever, abdominal distention and lumbar distention. All cases were followed up for 12 months. Twenty cases were cured, 10 cases performed better, and 6 cases developed re-stenosis. Treatment efficacy was around 83.3%(30/36). Conclusions Super-mini percutaneous nephroscope combined with flexible ureteroscope balloon dilation has the advantages of less bleeding, less trauma, shorter hospital stay, and remarkable curative effect, which is worthy of clinical popularization and application.