1.Influence of brightness value of supranasal point and apex nasi on dominant wavelength and excitation purity in complexion inspection of healthy adults.
Zhirong ZHU ; Changchun ZENG ; Li YANG ; Hanping LIU ; Songhao LIU
Journal of Integrative Medicine 2011;9(12):1333-8
In this study, to analyze the influence of the brightness value of the supranasal point and the apex nasi on their dominant wavelength and excitation purity according to the spectrocolorimetry data of the supranasal point and the apex nasi in healthy adults that were collected based on optical spectrum colorimetry.
2.Effect of the electroacupuncture treatment of vascular dementia and its P300
Feizhi MO ; Jianqiang LI ; Li CHU ; Liping LEI ; Xinsheng LAI ; Songhao LIU
Chinese Journal of Rehabilitation Theory and Practice 2000;6(2):65-69
Objective:To probe the effects of the electroacupuncture on vascular dementia and its P300.Methods:60 patients suffering from vascular dementia were randomly divided into two groups,the electroacupuncture group(30 cases) and the medicine group(dihydroergotoxine,DHET,30 cases).Changes in scoring value of HDS-R(Hasegawa Dementia Scale),FAQ(Functional Activity Questionaire),ADL,injure of nerve function,main symptoms and P300 were observed before and after treatment.The course was 42 days.Results:The results was that effective rate was 60% in electroacupuncture group and 23.33% in medicine group(P<0.01).All the above indices were improved in electroacupuncture group,better than those of medicine group(P<0.05~0.01).Conclusion:It suggests that the electroacupuncture therapy can promote the VD patients in intelligence,functional activity,ability of daily living and quality of life.
3.Colorimetric investigation of normal tongue and lip colors from 516 healthy adults by visible reflection spectrum.
Changchun ZENG ; Li YANG ; Ying XU ; Peipei LIU ; Shijun GUO ; Songhao LIU
Journal of Integrative Medicine 2011;9(9):948-54
Using the data from normal tongue and lip colors of normal people which were collected by the visible reflection spectrum, we analyzed the colorimetric parameters of tongue and lip colors.
4.Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes.
Wenhui TAO ; Dongyang ZHAO ; Guanting LI ; Lingxiao LI ; Songhao LI ; Hao YE ; Chutong TIAN ; Yutong LU ; Shuying LI ; Yinghua SUN ; Zhonggui HE ; Jin SUN
Acta Pharmaceutica Sinica B 2022;12(3):1487-1499
The unique characteristics of the tumor microenvironment (TME) could be exploited to develop antitumor nanomedicine strategies. However, in many cases, the actual therapeutic effect is far from reaching our expectations due to the notable tumor heterogeneity. Given the amplified characteristics of TME regulated by vascular disrupting agents (VDAs), nanomedicines may achieve unexpected improved efficacy. Herein, we fabricate platelet membrane-fusogenic liposomes (PML/DP&PPa), namely "platesomes", which actively load the hypoxia-activated pro-prodrug DMG-PR104A (DP) and physically encapsulate the photosensitizer pyropheophorbide a (PPa). Considering the different stages of tumor vascular collapse and shutdown induced by a VDA combretastatin-A4 phosphate (CA4P), PML/DP&PPa is injected 3 h after intraperitoneal administration of CA4P. First, CA4P-mediated tumor hemorrhage amplifies the enhanced permeation and retention (EPR) effect, and the platesome-biological targeting further promotes the tumor accumulation of PML/DP&PPa. Besides, CA4P-induced vascular occlusion inhibits oxygen supply, followed by photodynamic therapy-caused acute tumor hypoxia. This prolonged extreme hypoxia contributes to the complete activation of DP and then high inhibitory effect on tumor growth and metastasis. Thus, such a combining strategy of artificially-regulated TME and bio-inspired platesomes pronouncedly improves tumor drug delivery and boosts tumor hypoxia-selective activation, and provides a preferable solution to high-efficiency cancer therapy.