Objective To discuss the application and effect of Comprehensive Nursing Intervention on Patients with Hemiparesis of Cerebral Apoplexy. Methods A total of 80 cases of patients with hemiparesis of cerebral apoplexy were selected and divided into observation group and control group at random. The patients in two groups were given medicine treatment such as the control of intracranial pressure, blood pressure and blood sugar, brain cells nutrition, cerebral microcirculation improvement and etc. The patients in control group were given routine nursing intervention for 8 weeks, while the patients in observation group were additionally given comprehensive nursing intervention for 8 weeks. Results After 8 weeks’ nursing intervention, the total effective rate of recovery of neurological functions and the activity of daily living of patients in observation group was improved much better than that in control group(χ2=6.05 and 7.00,P<0.05). Meanwhile, the scores of life quality obviously were rose than before (P<0.05 or P<0.01), and the rising rate of patients in observation group was much higher than that in control group (P<0.05). Conclusion The comprehen-sive nursing intervention can obviously improve the recovery of neurological function, the activity of daily living and the life quality with hemiparesis of cerebral apoplexy, reduce the disability rate, and it is beneficial to the early recovery.

Objective To discuss influence of nursing intervention on negative emotion and cognitive function of pa-tients with agitans paralysis(PD). Methods A total of 78 cases of patients with PD were divided into nursing interven-tion group and routine nursing group. The patients in two groups were given routine medical treatment for PD. The pa-tients in routine nursing group and nursing intervention group were given routine nursing and comprehensive nursing re-spective ly for 8 weeks. The changes of depression, anxiety and other negative emotion and cognitive function of pa-tients in two groups were observed and compared before and after intervention. Results After 8 weeks'intervention,the SDS and SAS scores of patients in two groups were obviously rose than before (P<0.05 or P<0.01),and the rising rate of patients in nursing intervention group was much higher than those in routine nursing group (P<0.05). Meanwhile,MoCA and MMSE scores of patients in two groups were obviously rose than before (P<0.05 or P<0.01),and the rising rate of patients in nursing intervention group was much higher than that in routine nursing group(P<0.05). Conclusion Comprehensive nursing intervention can reduce or release the depression and anxiety symptom of patients with PD,sta-bilize the emotion of patients, which is advantageous for the recovery of cognitive function of patients, postpones the declining of cognitive function and reduces or prevents the occurrence of dementia.

Objective To discuss improvement effect of butylphthalide soft capsules on cognitive function of patients with cerebral arterial thrombosis in recovery period. Methods A total of 86 cases of patients with cerebral arterial thrombosis in recovery period were divided into observation group and control group at random. The patients in two groups were given the basic medical treatment such like depressurization, glucose-lowering, lipid-regulating, anti-platelet aggregation, cerebral circulation improvement and etc. The patients in observation group were additionally given butylphthalide soft capsules, 0.2 g per time, three times a day, while the patients in control group were additionally given piracetam tablets, 1.2 g per time, three times a day for 14 days. The changes of cognitive function indexes of pa-tients in two groups before and 14 days after the medical treatment were observed, and the curative effect and security evaluation were carried on as well. Results After 14 days’ medical treatment, WMS and MOCA scores of patients in two groups were obviously rose (P<0.05 or P<0.01), and the rising rate of patients in observation group was much high-er than that in control group (P<0.05). Meanwhile, total improvement rate of cognitive function of patients in observa-tion group was 95.35%, much higher than that in control group (79.07%) (χ2=5.11, P<0.05). 8 cases of drug adverse re-action (DAR) of patients in two groups were appeared during the medical treatment, 3 cases in observation group and 5 cases in control group, with light symptom. After comparing the untoward effect of patients in two groups, no statistical differences were appeared (χ2=0.14, P>0.05). Conclusion Butylphthalide soft capsules has favorable improvement effect on the declining of cognitive function of patients with cerebral arterial thrombosis in recovery period, which can en-hance the recovery of cognitive function of patients with favorable security.

Objective To systematically evaluate the efficacy and safety of duloxetine and sertraline for Chinese depression patients.Methods The randomized controlled trials(RCTs)comparing the efficacy and safety of duloxetine and sertraline in the treatment of depression were retrieved from databases and the quality of literature was evaluated.Meta-analysis was performed with the software Revman 5.2.Results Eighteen RCTs involving 1 557 Chinese depression patients were included.The results of Meta-analysis showed that there were no significant differences in efficacy and cure rate between duloxetine and sertraline groups(OR=1.28, 95%CI:0.94 -1.73, P =0.11; OR =1.25,95%CI:0.97 -1.62,P =0.09, respectively).The Hamilton Depression Scale(HAMD)scores were significantly lower in duloxetine group than those in sertraline group at 1,2 weeks after treatment;however,there were no significant differences at 8-weeks after treatment between duloxetine and sertraline groups.The score of Medical Outcomes Study Pain Measures(MOSPM)in duloxetine group was significantly lower than that in sertraline group(P<0.01). The rate of insomnia in duloxetine group was significantly lower than that in sertraline group(RR=0.57, 95%CI:0.32 -1.00, P=0.04).There were no significant differences in other common side reactions between the two groups(P>0.05).Conclusions Duloxetine has similar long term treatment effect as sertraline,but it has a rapid-action profile.Duloxetine is more effective than sertraline in depression with painful physical symptoms;besides,duloxetine is less likely to induce insomnia.

Objective To evaluate the effect of quality control circle ( QCC) application on releasing emergency nurse’ s workplace violence of posttraumatic stress disorder.Methods We utilized digital table method to divide forty five emergency nurses in certain hospitals who suffered workplace violence at first time into two groups randomly:experimental group ( twenty four cases) and control group ( twenty one cases) .Emergency nurses in the experimental gruop received psychological crisis interventions by QCC team while nurses in the control group were given general psychological interventions.The questionnaire survey occurred at early period (in the first week) and after three months of violence including demographic information questionnaire, the sense of job accidie questionnaire, PTSD-SS and WCQ, and analyzed the result of survey.Results At the early stage of suffered violence, the score of PTSD-SS, job accidie and the score coping style had no statistical difference (P>0.05).After three months, the nurse in experimental group acquired the score of subjective assessment (2.01 ±0.19), social function (5.03 ±1.09), re-experienced (20.12 ±1.80), withdrawal symptoms (20.11 ±3.98) were lower than control group [(3.09 ±0.23),(6.63 ±1.27),(26.31 ±1.91), (28.92 ±4.7), respectively],the differences were statistically significant (t=2.516,2.121,2.331,2.453, respectively;P<0.05).The score of job accidie sense, positive coping style and negative coping style obtained (3.51 ±1.01),(34.29 ±7.17) and (14.98 ±1.94) in the experimental group, while nurses in the control group achieved (3.51 ±1.01),(34.29 ±7.17) and (14.98 ±1.94) respectively,the differences were statistically significant (t=2.118,2.098,2.382, respectively;P<0.05).The vigilance increasing score had no statistical significance(15.33 ±3.24) in the experimental group and (17.98 ±3.30) in the control group (t=0.762,P>0.05).After three months’ intervention, the score of PTSD-SS, job accidie and negative coping style decreased while positive coping style increased in the experimental group (P<0.05).Meanwhile, the control group just increased vigilance increasing score (P<0.05).Conclusions The QCC is effective to promote psychological wellbeing when emergency nurses suffered workplace environment and benefits to recover.

Objective To investigate the effect of graded motor imagery ( GMI) therapy combined with rou-tine occupational therapy on the recovery of upper extremity function after stroke. Methods Thirty stroke survivors who met inclusion criteria were randomly assigned to a control group ( n=15) or a GMI group ( n=15) . The control group received routine medication, conventional physical therapy and routine occupational therapy ( one hour a day) , while the GMI group received 30 minutes of routine occupational therapy and 30 minutes of graded motor imagery therapy every day in addition to conventional medication and physical therapy. Before and after four weeks of treat-ment, the patients in both groups were evaluated using the Fugl-Meyer Assessment for the Upper Extremities ( FMA-UE) , the Box and Block Test ( BBT) and Brunnstrom arm and hand staging. Surface electromyography of the biceps brachii and triceps brachii was performed as the affected elbow flexed and stretched in maximum isometric contrac-tions, and the co-contraction ratios ( CRs) were calculated. Results After the treatment, the average FMA-UE score, Brunnstrom arm and hand stage, BBT and CR scores in both groups had improved significantly. The average improvement in the GMI group was significantly greater than in the control group. Conclusions Graded motor im-agery therapy can significantly promote motor recovery of the upper extremities of hemiplegic patients after a stroke.

Objective To observe changes of spatial learning-memory in rats with chronic hypoxic hypercapnia and the effect of gingkgo biloba extra. Methods After established the rat model of chronic hypoxic hypercapnia,seventy-two rats were randomly divided into four groups normal control (NC),hypoxic-hypercapnia 4-week (4HH),hypoxic-hy-percapnia 4-week+gingkgo biloba extra (EGb)high dose(100 mg/kg)group[4HH+EGb(H)] and hypoxic-hypercapnia 4-week+EGb low dose (50 mg/kg) group[4HH+EGb(L)]. Praxiology in rats was asessed by the Morris water maze and step down test. Results The spatial learning-memory in rats exposed to chronic hypoxic-hypercapnia 4-week(4HH group)were displayed significant impairment in their performance,the longer mean escape latencies and swim path dis tances,the more error times. 4HH+EGb(H) and 4HH+EGb(L)groups shortened the reaction time of leaning, pro longed the latent time of memory, reduced times of mistakes. Conclusions EGb can enhance the capacity of learning-memory in the rats exposed chronic hypoxic hypercapnia.