Objective To investigate the clinical efficacy of mecobalamin Zusanli acupoint injection combined with α-lipoic acid intravenous infusion in the treatment of patients with diabetic peripheral neuropathy.Methods From February 2016 to August 2017,80 patients with diabetic peripheral neuropathy in Zhoushan Hospital were divided into control group and treatment group according to different treatment methods,with 40 cases in each group.The two groups were given diet,exercise and medication.At the same time,the control group was given mecobalamin Zusanli acupoint injection,the treatment group was given α-lipoic acid intravenous infusion on the basis of the control group.After 2 weeks of treatment,the clinical curative effect was evaluated.The scores of MDNS before and after treatment were evaluated.The motor nerve conduction velocity (MNCV),sensory nerve conduction velocity (SNCV),and the shortest F wave latent period velocity of the tibial nerve were compared before and after treatment in the two groups.The adverse reactions during treatment in the two groups were recorded.Results The total effective rate of the treatment group was 87.5％,which was significantly higher than 52.5％ of the control group(x2 =12.621,P =0.001).The MDNS score of the treatment group after 2 weeks of treatment was (1.82 ±0.74)points,which was significantly lower than (2.45 ± 0.89) points of the control group (t =3.442,P =0.000).After treatment,the MNCV of the common peroneal nerve of the treatment group was (48.12 ±4.98) m/s,which was significantly higher than (42.68 ± 4.59)m/s of the control group (t =5.080,P =0.000).The median nerve MNCV of the treatment group was (53.31 ± 4.41)m/s,which was significantly higher than (49.85 ± 3.87)m/s of the control group (t =3.729,P =0.000).After treatment,the SNCV of the common peroneal nerve in the treatment group was (42.73 ± 4.28) m/s,which was significantly higher than (39.57 ± 3.65) m/s in the control group (t =3.552,P =0.000).The median nerve SNCV of the treatment group was (46.98 ± 3.47) m/s,which had no statistically significant difference compared with that of the control group [(45.79 ± 3.56) m/s] (t =1.513,P =0.134).The shortest F wave latent period velocity of the tibial nerve in the treatment group was (45.82 ±4.12) m/s,which was significantly higher than (42.68 ± 3.25) m/s in the control group(t =3.784,P =0.000).The two groups had no obvious adverse reactions during treatment.Conclusion Mecobalamin Zusanli acupoint injection combined with α-lipoic acid intravenous infusion in the treatment of patients with diabetic peripheral neuropathy is effective and safe,and it is worthy of promoting.