Objective To investigate effect of dicoumarol on the expression of serum tumor necrosis factor-α( TNF-α) in patients with acute cerebral infarction.Methods Eighty cases patients with acute cerebral infarction were admitted and randomly divided into two groups by digital draw:control group and observation group, 40 cases in each group.The control group were given conventional therapy for treatment of acute cerebral infarction, and observation group were given dicoumarol thrombolysis on the basis of control group.The serum TNF-αlevel and neurologic impairment score were compared between two groups pre-and post-treatment.Results After treatment of 6 h, the serum TNF-αlevel in observation group was significantly lower than that in control group (P<0.05).After treatment of 24 h, 48 h and 30 d, there were no significant differences of serum TNF-αlevels between two groups.After treatment of 5 d, 14 d and 28 d, the neurological deficit scores in observation group were significantly higher than those in control group (P<0.05).Conclusion Dicoumarol could effectively reduce TNF-αlevels in serum and extent of cerebral cell damage in patients.

Objective:to study alexithymia of long-term survivors of cancers. Method:to compare 36 long-term survivors of cancers and 45 normal controls with TAS (Toronto alexithymia scale) and SCL-90.Result:there was no significant difference between the two groups in total score of SCL-90. But the survivors had significant higher score in TAS than controls.Conclusion:although long-term survivors are similar in symptom level to normal control, they still have obvious alexithymia.

Objective To investigate the effects of exercise on behavior and serum cortisol levels in depression caused by chronic,unpredictable,mild stress(CUMS).Methods Forty-eight male Sprague-Dawley rats were randomly divided into 3 groups:A,B and C.Each group was then divided into 3 subgroups:a blank control subgroup,a model subgroup,and an intervention subgroup.CUMS such as unpredictable forced swimming in cold water,electric stimulation of the animals'feet and shaking of the cage was used to establish a model of depression.Swimming exercise was administered as a therapeutic intervention.In group A it was administered while the animals were under stress,while in groups B and C,exercise was administered before and after the depression model had been established.Open-field test and fluid consumption data were recorded during the whole procedure.At the end of the experiment,radioimmunity assays were used to measure the levels of serum cortisol.Results Rats exposed to CUMS showed reduced water consumption;a preference for sucrose solutions;and decreased squares crossed,less rearing and increased bowel movement in open-field test.All of these changes were mitigated by the exercise performed while the animals were under stress,but not by exercise before or after the depression model had been established.Rats exposed to CUMS showed significant increases in serum cortisol,which was mitigated by exercise prior to and during stress.Conclusion Different exercise routines have different effects on behavior and serum cortisol levels in depressive rats under chronic unpredictable mild stress.Exercise has cumulative effects in decreasing the serum level of cortisol,but has only immediate effects on the behavior of depressive rats.

Objective To detect the proteus and analyze the drug-resistance in intensive care unit.Methods From Jan 2005 to Dec 2006,proteus was detected by Disc diffusion test(K-B method)to study the antimicrobial resistance in ICU and general ward,and compared the drug-resistance.Results The isolating rate of proteus was 80.9% in sputum,and proteus mirabilis accouted for 80.4%.The resistance rates to ciprofloxacin,amikacin,cefotaxim,ceftazidime,cefmetazole and piperacillin/Tazobactam were between 64%~77%,and 32%~41% in imipenem and cefoperazone/sulbactam.Compared with general ward,the antibiotic resistant rate existed significant difference.And the antibiotic resistant rate of other type proteus had significant difference between ICU and general ward.Conclusion Properly detecting Proteus in time is imporrant to use antibiotic and to avoid nosocomial outbreak infections by Proteus.

Objective To analyze the correlation between the stability of carotid atherosclerostic plaque and serum in-sulin-like growth factor-1 (IGF-1) in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction who were admitted to our hospital from January 2012 to January 2014 were selected as an observa-tion group, and 50 healthy volunteers who received physical examination in our hospital at the same period of time were selected as a control group. ELISA method was applied to measure the level of serum IGF-1 in subjects, and carotid color ultrasonography was applied for examination in subjects. On the basis of the results of examination, the subjects were divided into stable plaque group, instable plaque group and plaque-free group. Results The detection rate of in-stable plaque, stable plaque, plaque-free and total plaque detection rate in the observation group were 42.0%, 25.0%, 33.0% and 67.0% respectively, in the control group were 8.0%, 18.0%, 74.0% and 26.0%. The differences were statis-tically significant (P<0.05). Serum IGF-1 level in the plaque-free group was significantly higher than that in the stable plaque group, and serum IGF-1 level in the plaque-free group and stable plaque group was significantly higher than that in the instable plaque group. The differences were statistically significant (P<0.05). One-way analysis of variance was applied in the comparison between multiple groups, F=4.158, P=0.006. The differences of neurological function and mental states before the treatment in the stable plaque group and instable plaque group were not statistically signifi-cant (P>0.05), and the neurological function and mental states after the treatment in the stable plaque group were signif-icantly better than those in the instable plaque group. The differences were statistically significant (P<0.05). Conclusion Patients with cerebral infarction have relatively higher incidence of carotid atherosclerostic plaque, and patients with stable carotid atherosclerostic plaque have higher serum IGF-1 level. The reduction of serum IGF-1 level is closely correlated with the formation of instable carotid atherosclerostic plaque.