OBJECTIVE: To prepare fumeisong cream and establish its quality control method. METHODS: Ingredients including carbamide, triamcinolone acetonide acetate, camphor, and laurocapram were mixed in an oil-in-water matrix for preparation of fumeisong cream. HPLC was adopted to determine the content of triamcinolone acetonide in the cream. RESULTS: The prepared cream was white in color, with test items all in line with specifications stipulated in 2005 version of China Pharmacopoeia. The linearity concentration range of triamcinolone acetonide was 2.06～20.6 ?g?mL-1(r=0.999 6) and the average recovery rate was 99.6% (RSD=1.0%,n=9). CONCLUSION: The cream is simple and feasible in preparation techniques, and its quality is stable and controllable.

Carotid artery stenosis is one of the main causes of ischemic stroke. Carotid artery stenting has gradually become a mainstream treatment approach of carotid stenosis, and the in-stent restenosis is its most common late complications, which restricts the development of carotid artery stenting. This article reviews the epidemiology, imaging evaluation, pathophysiological mechanism, and prevention and treatment measures of carotid in-stent restenosis.

Objective To investigate effects of driving fatigue on working memory. Methods The control group included 12 taxi drivers after adequate rest while the fatigue group included 27 taxi drivers who had been driving for 10h. Digit memory span, words span, Digit Subtraction Test, Random Number Generation test were used. Results Compared with the control(6.60 ±0.40,90.67 ±6.65,158.27 ±29.12,0.30 ±0.06,24.29 ±10.59,35.90 ± 10.64 ), driving fatigue group were significantly( P ＜ 0.05 )different in the number of backward number memory span( 5.37 ± 0.72 ), percentage of number of right reaction of the number of total reaction of Digit Subtraction Test(79.95 ± 8.04), total number of RNG( 88.33 ± 19.48 ), RNG(0.40 ± 0.05 ), Coupon( 12.35 ±12.88), NSQ(49.72 ± 8.06). Conclusion Driving fatigue can decline the working memory.

Objective To explore the correlation between the parameters of ambulatory blood pressure monitoring (ABPM) and prostatic volume in elderly patients with essential hypertension.Methods The 131 elderly patients with essential hypertension from March 2007 to December 2009 were enrolled in this study, including 102 benign prostatic hyperplasia (BPH) patients and 29 nonBPH (NBPH) patients. All patients underwent ABPM and ultrasound examination of prostate.Prostatic volumes (PV) were calculated and were compared between BPH group and NBPH group.Correlation between parameters of ABPM and PV was analyzed. Results (1)The maximal mean artery pressure (MAPmax) at night was higher in BPH group than in NBPH group [( 104.7 ± 12. 0)mm Hg vs. (99.6± 10. 1) mm Hg, P= 0.039]. (2)There were correlations between PV and MAPmax in all-day (r=0. 184, P=0. 035), MAPmax at daytime (r=0. 183, P=0. 037), MAPmax at night (r=0. 181, P=0. 040), respectively. Conclusions MAPmax of ABPM may be associated with PV in elderly patients with essential hypertension.

ObjectiveTo investigate the diagnostic and prognostic significance of serum human kallikrein11 ( KLK11 ) in patients with ovarian cancer. MethodsThe level of serum KLK11 was determined by enzyme-linked immunoassay(ELISA) for 30 patients with ovarian cancer, 26 patients with benign gynecologic processes and 32 healthy subjects,and the KLK11 value beyond the upper-limit of 95％ credibility interval( 95％ CI) based on the health controls was used as the positive value. The positive rate of KLK11 was compared among the three groups.ResultsThe positive rate of KLK11 in patients with ovarian cancer was significantly higher than those in patients with benign gynecologic processes or in healthy subjects[(73.3％) and(7.7％ ) or(6.3％ ) ,all P ＜0.01 )] ,and there was no significant difference between ovarian benign tumor group and the healthy control group ( P ＞ 0.05 ).ConclusionThe serum KLK11 should be a novel tumor marker in the clinical diagnosis of ovarian cancer.

Takayasu arteritis (TA) is a devastating vasculitis of the aorta and its major branches,coronary and pulmonary arteries.The clinical manifestations in children are less specific than in adnlts:the disease in children presents with fever,arthralgias,vomiting,weight loss and hypertension.Conventional angiography,which is recognized as the golden standard in evaluating vascular lesions in TA,combined with computer tomography angiography (CTA),magnetic resonance angiography (MRA),ultrasonography,could not only provide important information for early diagnosis,but also detect disease activity.New immunosuppressive agents and biological therapies,such as TNF-a blocking agents,have been verified to be effective although corticosteroids and conventional immunosuppressive agents are still basic treatment.

Breast cancer is caused by somatic mutation. As such, somatic mutation in breast cancer should be described to eluci-date the underlying mechanism. Next-generation sequencing has provided new insights into the genomics of breast cancer. New genes were identified and exhibited a relationship with breast cancer. Although these genes mutated at a low frequency, such genes in different cases could be categorized into specific pathways. Mutational signatures could be found in some cases, but such signatures were gener-ally not related to environmental exposure. Studies on intra-tumoral heterogeneity have revealed the ubiquitous presence of sub-clones in breast cancer;however, a major clone is also observed, accounting for>50%of tumor cells. Current advancements show that breast cancer genomics has been integrated into personalized medicine. Furthermore, a genome-informed and personalized molecular sub-typ-ing and treatment of breast cancer can be developed in the future.

Tuberculosis of bone and joint most commonly occurs in spine, and the main treatment method is anterior debridement, bone grafting and internal fixation. Autologous bone is still considered the "gold standard" when the anterior reconstruction of spine after debridement is needed. Allogeneic bone, artificial bone and artificial intervertebral support bodies such as titanium mesh and some biological materials also have a broad clinical application, but still can not completely replace the autologous bone because of their defects. In the aspect of internal fixation, anterior fixation has become a conventional method for the patients who suffer from active spinal tuberculosis and need anterior debridement of the focus, because this method can provide good support. This review summarizes the present situation of choice for supporting and bone grafting material for anterior reconstruction after debridement of spinal tuberculosis.

Objective To understand the pregnancy outcomes and risk factors in pregnant women infected with Toxoplasma gondii. Methods Toxoplasma IgM and IgG antibodies in sera from 2 740 cases of pregnant women were detected by using enzyme-linked immunosorbent assay(ELISA)in Zhuozhou Municipal Maternal and Child Health Care Center from 2010 to 2013,and the pregnancy outcomes were followed up. The risk factors for Toxoplasma infection were investigated with questionnaires. Results Among the 2 740 cases of pregnant women,195 cases were found with antibodies to T. gondii(7.12%),and among them,44 cas-es were IgM positive(22.56%),and 151 cases were IgG positive(77.44%). There were 41 cases with adverse pregnancy out-comes among the 195 cases(21.02%),including 32 cases of IgM positive(78.05%)and 9 cases of IgG positive(21.95%). There were 6 cases of adverse pregnancy outcomes in uninfected pregnant women(2.86%). The difference between the two groups was statistically significant(P<0.05). The close contact with animals,eating raw meat,eating chafing dish or barbeque,and eating raw meat stuffing were important risk factors in pregnant women infected with T. gondii(compared with the uninfected group,P<0.01). Conclusion The Toxoplasma infection may lead to adverse pregnancy outcomes,therefore,to develop good habits of life and health is an effective way to avoid adverse pregnancy outcomes.

Objective To investigate the effect of bilateral uterine artery embolization in the prevention of postpartum hemorrhage.Methods Twenty-seven patients with risk factors of postpartum hemorrhage (prevention group) and 36 patients with postpartum hemorrhage refractory tendency(treatment group) were underwent bilateral uterine artery embolization.The clinical efficacy and side effects were observed.Results The patients in prevention group were given bilateral uterine artery embolization and conventional induction by ethacridine.All of them finished vaginal delivery,postpartum hemorrhage was 200-480 ml,average 385 ml,no case of postpartum hemorrhage.The patients in treatment group occurred intractable postpartum hemorrhage before bilateral uterine artery embolization,the amount of hemorrhage was 1 000-4 200 ml,average 2 050 ml.Among them,9 patients were given carbasus to stuff cavitary uteri,2 patients were given striped-back saturation.Effective in 35 patients,the successful rate was 97.2％ (35/36).One patient was performed with hysterectomy because of inefficient treatment.None occurred maternal deaths,inefficient and necrosis of lower limbs.All of patients had entire involution of uterus.Reviewed at clinic service after delivery,none occurred postpartum hemorrhage,puerperal infection,Sheehan's syndrome.The menstrual recovery time was 3-13 months for 53 patients who were followed up.Conclusions Bilateral uterine artery embolization have advantage such as safe,effective,less side effects,and is an effective method for the treatment of various causes of intractable postpartum hemorrhage.It is worthy of clinical application on the prevention of postpartum hemorrhage.