1.One Case of Systemic Lupus Erythematosus with Chief Complaint of Xerostomia and Abnormal Liver Function.
Je Wook YEON ; Song Yee BAEK ; Ho Woong CHO ; Youn Jeong SHIN ; Dong Sik U ; Eun Jin CHOI ; Mi Kyeong OH
Journal of the Korean Academy of Family Medicine 2004;25(6):475-480
Dry mouth is a common symptom in over middle- aged women. Xerostomia itself can be caused by multifactorial etiolgy. Dry mouth may occur with the use of medications, as a complication of connective tissue and autoimmune disease, such as Sjogren's syndrome or sicca syndrome, with radiation therapy to the head and neck or diabetes mellitus, or with a number of other condition. Even stress and anxiety can lead to a dry mouth. Also, Abnormal liver function is associated with drugs, viral infection, alcohol, obesity, autoimmne disease and a number of other disease. A 41-year-old women complaining of xerostomia and known abnormal liver fuction since 1 year was admitted to our medical examination center. In this case, Final diagnosis was systemic lupus erythematosus with autoimmune hepatitis and secondary Sjogren's syndrome through characteristic clinical finding, liver biopsy, positive Schirmer's test, salivary gland biopsy, and salivary scintigraphy. The various immunosuppresant medication has taken and then liver function indices and clinical symptoms were improved.
Adult
;
Anxiety
;
Autoimmune Diseases
;
Biopsy
;
Connective Tissue
;
Diabetes Mellitus
;
Diagnosis
;
Female
;
Head
;
Hepatitis, Autoimmune
;
Humans
;
Liver*
;
Lupus Erythematosus, Systemic*
;
Mouth
;
Neck
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Obesity
;
Radionuclide Imaging
;
Salivary Glands
;
Sjogren's Syndrome
;
Xerostomia*
2.Comparison of the Seroprevalence of Measles Antibodies among Healthcare Workers in Two Korean Hospitals in 2019
Yee Gyung KWAK ; Je Eun SONG ; Gang-Bok OH ; In Hye JEONG ; Chong Rae CHO ; Namhee KIM ; Hyeon Mi YOO ; Gyeong Min YOO ; Myung Jin LEE ; Baek-Nam KIM
Infection and Chemotherapy 2020;52(1):93-97
We performed a point seroprevalence survey of measles among healthcare workers (HCWs) at two Korean teaching hospitals in 2019. A total of 2,830 HCWs underwent an antibody test.The overall seropositivity of measles was 93.1%. The seroprevalence of measles was lowest in HCWs aged 20 - 24 years (81.2%), followed by those aged 25 - 29 years (90.1%). The rates of anti-measles IgG positivity were significantly different between the two hospitals (97.0% vs.89.4%, P <0.001). These results suggest that the seropositivity of measles in HCWs may differ depending on the hospital's vaccination policy.
3.Low Compliance with National Guidelines for Preventing Transmission of Group 1 Nationally Notifiable Infectious Diseases in Korea.
Eu Suk KIM ; Kyoung Ho SONG ; Baek Nam KIM ; Yee Gyung KWAK ; Chang Seop LEE ; Sang Won PARK ; Chisook MOON ; Kyung Hwa PARK ; Hee Chang JANG ; Joon Sup YEOM ; Won Sup OH ; Chung Jong KIM ; Hong Bin KIM ; Hyun Sul LIM
Yonsei Medical Journal 2014;55(2):435-441
PURPOSE: This study was performed to evaluate the compliance with, and adequacy of, the Korean national guidelines which had been recommended until 2011 for isolation of patients with group 1 nationally notifiable infectious diseases (NNIDs), namely cholera, typhoid fever, paratyphoid fever, shigellosis, and enterohemorrhagic Escherichia coli (EHEC) infection. MATERIALS AND METHODS: We evaluated the clinical and microbiological characteristics of confirmed cases of group 1 NNIDs and compliance with the guidelines in 20 Korean hospitals nationwide in 2000-2010. We also compared the Korean guidelines with international guidelines. RESULTS: Among 528 confirmed cases (8 cases of cholera, 232 of typhoid fever, 81 of paratyphoid fever, 175 of shigellosis, and 32 EHEC infections), strict compliance with the Korean guideline was achieved in only 2.6% to 50.0%, depending on the disease. While the Korean guidelines recommend isolation of all patients with group 1 NNIDs, international guidelines recommend selective patient isolation and screening for fecal shedding, depending on the type of disease and patient status. CONCLUSION: Compliance with the previous national guidelines for group 1 NNIDs in Korea was generally very low. Further studies are needed to evaluate whether compliance was improved after implementation of the new guideline in 2012.
Cholera
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Communicable Disease Control
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Communicable Diseases*
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Compliance*
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Dysentery, Bacillary
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Enterohemorrhagic Escherichia coli
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Guideline Adherence
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Humans
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Korea*
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Mass Screening
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Methods
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Paratyphoid Fever
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Patient Isolation
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Typhoid Fever
4.Use of the Monoclonal Antibody Regdanvimab to Treat Patients Hospitalized with COVID-19:Real-World Data during the Delta Variant Predominance
Yee Gyung KWAK ; Je Eun SONG ; Jieun KANG ; Jiyeon KANG ; Hyung Koo KANG ; Hyeon-Kyoung KOO ; Hye Kyeong PARK ; Sang Bong CHOI ; Hyuk Pyo LEE ; Myung Jin LEE ; Baek-Nam KIM
Infection and Chemotherapy 2022;54(4):781-786
Regdanvimab is the only monoclonal antibody available in Korea that targets severe acute respiratory syndrome coronavirus 2. We retrospectively evaluated the clinical characteristics of 374 adults hospitalized with coronavirus disease 2019 (COVID-19) who were treated with regdanvimab from September through December 2021. In total, 322 (86.1%) patients exhibited risk factors for disease progression. Most patients (91.4%) improved without additional treatment. No patient died or was transferred to intensive care. This study shows that regdanvimab prevented disease progression in high-risk patients with mild to moderate COVID-19 infections during Delta variant predominance.
5.Four Times of Relapse of Plasmodium vivax Malaria Despite Primaquine Treatment in a Patient with Impaired Cytochrome P450 2D6 Function
Sungim CHOI ; Heun CHOI ; Seong Yeon PARK ; Yee Gyung KWAK ; Je Eun SONG ; So Youn SHIN ; Ji Hyeon BAEK ; Hyun-IL SHIN ; Hong Sang OH ; Yong Chan KIM ; Joon-Sup YEOM ; Jin-Hee HAN ; Min Jae KIM
The Korean Journal of Parasitology 2022;60(1):39-43
Plasmodium vivax exhibits dormant liver-stage parasites, called hypnozoites, which can cause relapse of malaria. The only drug currently used for eliminating hypnozoites is primaquine. The antimalarial properties of primaquine are dependent on the production of oxidized metabolites by the cytochrome P450 isoenzyme 2D6 (CYP2D6). Reduced primaquine metabolism may be related to P. vivax relapses. We describe a case of 4 episodes of recurrence of vivax malaria in a patient with decreased CYP2D6 function. The patient was 52-year-old male with body weight of 52 kg. He received total gastrectomy and splenectomy 7 months before the first episode and was under chemotherapy for the gastric cancer. The first episode occurred in March 2019 and each episode had intervals of 34, 41, and 97 days, respectively. At the first and second episodes, primaquine was administered as 15 mg for 14 days. The primaquine dose was increased with 30 mg for 14 days at the third and fourth episodes. Seven gene sequences of P. vivax were analyzed and revealed totally identical for all the 4 samples. The CYP2D6 genotype was analyzed and intermediate metabolizer phenotype with decreased function was identified.
6.Radiofrequency Ablation of Benign Thyroid Nodules and Recurrent Thyroid Cancers: Consensus Statement and Recommendations.
Dong Gyu NA ; Jeong Hyun LEE ; So Lyung JUNG ; Ji hoon KIM ; Jin Yong SUNG ; Jung Hee SHIN ; Eun Kyung KIM ; Joon Hyung LEE ; Dong Wook KIM ; Jeong Seon PARK ; Kyu Sun KIM ; Seon Mi BAEK ; Younghen LEE ; Semin CHONG ; Jung Suk SIM ; Jung Yin HUH ; Jae Ik BAE ; Kyung Tae KIM ; Song Yee HAN ; Min Young BAE ; Yoon Suk KIM ; Jung Hwan BAEK
Korean Journal of Radiology 2012;13(2):117-125
Thermal ablation using radiofrequency is a new, minimally invasive modality employed as an alternative to surgery in patients with benign thyroid nodules and recurrent thyroid cancers. The Task Force Committee of the Korean Society of Thyroid Radiology has developed recommendations for the optimal use of radiofrequency ablation for thyroid nodules. These recommendations are based on a comprehensive analysis of the current literature, the results of multicenter studies, and expert consensus.
Biopsy, Fine-Needle
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Catheter Ablation/*methods
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Consensus
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Humans
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Informed Consent
;
Neoplasm Recurrence, Local/parasitology/surgery
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Patient Safety
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Radio Waves
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Republic of Korea
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Thyroid Neoplasms/pathology/*surgery
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Thyroid Nodule/pathology/*surgery
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Ultrasonography, Interventional
7.Radiofrequency Ablation of Benign Thyroid Nodules and Recurrent Thyroid Cancers: Consensus Statement and Recommendations.
Dong Gyu NA ; Jeong Hyun LEE ; So Lyung JUNG ; Ji Hoon KIM ; Jin Yong SUNG ; Jung Hee SHIN ; Eun Kyung KIM ; Joon Hyung LEE ; Dong Wook KIM ; Jeong Seon PARK ; Kyu Sun KIM ; Seon Mi BAEK ; Younghen LEE ; Semin CHONG ; Jung Suk SIM ; Jung Yin HUH ; Jae Ik BAE ; Kyung Tae KIM ; Song Yee HAN ; Min Young BAE ; Yoon Suk KIM ; Jung Hwan BAEK
Journal of the Korean Society of Medical Ultrasound 2012;31(2):73-80
Radiofrequency ablation is a new non-surgical treatment modality for patients with benign thyroid nodules and recurrent thyroid cancers. The Task Force Committee of the Korean Society of Thyroid Radiology has developed recommendations for the treatment of benign thyroid nodules and recurrent thyroid cancers using radiofrequency ablation. These recommendations are based on evidence from the current literature and expert consensus.
Advisory Committees
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Consensus
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Ethanol
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Humans
;
Thyroid Gland
;
Thyroid Nodule
8.A Prediction Rule to Identify Severe Cases among Adult Patients Hospitalized with Pandemic Influenza A (H1N1) 2009.
Won Sup OH ; Seung Joon LEE ; Chang Seop LEE ; Ji An HUR ; Ae Chung HUR ; Yoon Seon PARK ; Sang Taek HEO ; In Gyu BAE ; Sang Won PARK ; Eu Suk KIM ; Hong Bin KIM ; Kyoung Ho SONG ; Kkot Sil LEE ; Sang Rok LEE ; Joon Sup YEOM ; Su Jin LEE ; Baek Nam KIM ; Yee Gyung KWAK ; Jae Hoon LEE ; Yong Keun KIM ; Hyo Youl KIM ; Nam Joong KIM ; Myoung Don OH
Journal of Korean Medical Science 2011;26(4):499-506
The purpose of this study was to establish a prediction rule for severe illness in adult patients hospitalized with pandemic influenza A (H1N1) 2009. At the time of initial presentation, the baseline characteristics of those with severe illness (i.e., admission to intensive care unit, mechanical ventilation, or death) were compared to those of patients with non-severe illnesses. A total of 709 adults hospitalized with pandemic influenza A (H1N1) 2009 were included: 75 severe and 634 non-severe cases. The multivariate analysis demonstrated that altered mental status, hypoxia (PaO2/FiO2 < or = 250), bilateral lung infiltration, and old age (> or = 65 yr) were independent risk factors for severe cases (all P < 0.001). The area under the ROC curve (0.834 [95% CI, 0.778-0.890]) of the number of risk factors were not significantly different with that of APACHE II score (0.840 [95% CI, 0.790-0.891]) (P = 0.496). The presence of > or = 2 risk factors had a higher sensitivity, specificity, positive predictive value and negative predictive value than an APACHE II score of > or = 13. As a prediction rule, the presence of > or = 2 these risk factors is a powerful and easy-to-use predictor of the severity in adult patients hospitalized with pandemic influenza A (H1N1) 2009.
APACHE
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Adult
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Aged
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Antiviral Agents/therapeutic use
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Female
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Hospitalization
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Humans
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Influenza A Virus, H1N1 Subtype/*isolation & purification
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Influenza, Human/drug therapy/*epidemiology/mortality
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Intensive Care Units
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Male
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Middle Aged
;
Pandemics
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Predictive Value of Tests
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ROC Curve
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Respiration, Artificial
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Risk Factors
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Severity of Illness Index