No abstract available.
Dexamethasone*

Cerebrocostomandibular syndrome is characterized by micrognathia, cleft palate, multiple thorax deformity and frequently, mental deficiency. Respiratory compromise is a common cause of death. We experienced a case of cerebrocostomandibular syndrome with congenital heart disease in a 2 day old female baby with the chief complaint of cyanosis and respiratory difficulty since birth. She was delivered by cesarian section due to delayed labor at IUP 42 weeks. The diagnosis was made on the basis of clinical features, radiologic findings and echocardiogram, which showed micrognathia, deformity of 3rd finger Lt, hemivertebrae of T1-T6 Lt., absence of 1-6th rib Lt., dextrocardia, tetralogy of fallot, atrial septal defect secondum. We reported this case and reviewed related litertures briefly.
Cause of Death ; Cleft Palate ; Congenital Abnormalities ; Cyanosis ; Dextrocardia ; Diagnosis ; Female ; Fingers ; Heart Defects, Congenital* ; Heart Septal Defects, Atrial ; Humans ; Intellectual Disability ; Parturition ; Ribs ; Tetralogy of Fallot ; Thorax

This study was performed to examine the effect of a 7-week comprehensive health promotion program for improving pain, depression, and disability by employing a quasi-experimental design. The subjects were regular out-patients of a RA aclinic in an University Hospital in Inchon from November 11. 1998 to December 24. 1998. The Experimental group included 18 patients who participated in an arthritis health promotion program, and the control group included 18 patients who did not. The 7-week health promotion program, which had the objective to enhance health promoting skills, was provided to patients. The effects of this program on the patients' pain, depression, and functional disability were examined. According to the study results, a significant group difference was found on these dependent variables (Hotelling's T =.30, F=3.11, p=.04). To examine which dependent variables had significant effects, one-way ANOVAs were performed. There were significant group differences in pain (F=4.35, p=.05) and in depression (F=4.22, p=.05) However, no significant group differences on functional disability (F=.04, p=.84) were found. Conclusively, the arthritis health promotion program, which was designed to enhance 11 health promoting skills, can be evaluated as successfully achieving the ultimate goal of enhancing the patients' quality of life. It can also be contended that the improvement of the patients' quality of life was enabled by relieving pain and reducing depression.
Arthritis ; Arthritis, Rheumatoid* ; Depression ; Health Promotion* ; Humans ; Incheon ; Outpatients ; Quality of Life ; Sulindac

This study was performed to examine the effect of a 7-week comprehensive health promotion program for improving pain, depression, and disability by employing a quasi-experimental design. The subjects were regular out-patients of a RA aclinic in an University Hospital in Inchon from November 11. 1998 to December 24. 1998. The Experimental group included 18 patients who participated in an arthritis health promotion program, and the control group included 18 patients who did not. The 7-week health promotion program, which had the objective to enhance health promoting skills, was provided to patients. The effects of this program on the patients' pain, depression, and functional disability were examined. According to the study results, a significant group difference was found on these dependent variables (Hotelling's T =.30, F=3.11, p=.04). To examine which dependent variables had significant effects, one-way ANOVAs were performed. There were significant group differences in pain (F=4.35, p=.05) and in depression (F=4.22, p=.05) However, no significant group differences on functional disability (F=.04, p=.84) were found. Conclusively, the arthritis health promotion program, which was designed to enhance 11 health promoting skills, can be evaluated as successfully achieving the ultimate goal of enhancing the patients' quality of life. It can also be contended that the improvement of the patients' quality of life was enabled by relieving pain and reducing depression.
Arthritis ; Arthritis, Rheumatoid* ; Depression ; Health Promotion* ; Humans ; Incheon ; Outpatients ; Quality of Life ; Sulindac

PURPOSE: Troglitazone (TRO) is a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist. TRO has antiproliferative activity on many kinds of cancer cells via G1 arrest. TRO also increases Cu2+/Zn2+-superoxide dismutase (CuZnSOD) and catalase. Cell cycle, and SOD and catalase may affect on radiation sensitivity. We investigated the effect of TRO on radiation sensitivity in cancer cells in vitro. MATERIALS AND METHODS: Three human cervix cancer cell lines (HeLa, Me180, and SiHa) were used. The protein expressions of SOD and catalase, and catalase activities were measured at 2-10 microM of TRO for 24 hours. Cell cycle was evaluated with flow cytometry. Reactive oxygen species (ROS) was measured using 2',7'-dichlorofluorescin diacetate. Cell survival by radiation was measured with clonogenic assay. RESULTS: By 5 microM TRO for 24 hours, the mRNA, protein expression and activity of catalase were increased in all three cell lines. G0-G1 phase cells were increased in HeLa and Me180 by 5 microM TRO for 24 hours, but those were not increased in SiHa. By pretreatment with 5 microM TRO radiation sensitivity was increased in HeLa and Me180, but it was decreased in SiHa. In Me180, with 2 microM TRO which increased catalase but not increased G0-G1 cells, radiosensitization was not observed. ROS produced by radiation was decreased with TRO. CONCLUSION: TRO increases radiation sensitivity through G0-G1 arrest or decreases radiation sensitivity through catalase-mediated ROS scavenging according to TRO dose or cell types. The change of radiation sensitivity by combined with TRO is not dependent on the PPARgamma expression level.
Catalase ; Cell Cycle ; Cell Line ; Cell Survival ; Cervix Uteri ; Chromans ; Female ; Flow Cytometry ; Fluoresceins ; Humans ; PPAR gamma ; Radiation Tolerance ; Reactive Oxygen Species ; RNA, Messenger ; Thiazolidinediones ; Uterine Cervical Neoplasms

BACKGROUND: In the Duffy blood group system (Fy(a), Fy(b), Fy(x), and Fy antigens), Fy(x) antigen is associated with weak Fy(b) while Fy antigen means the null phenotype Fy (a-b-). Fyx antigen and Fy antigen result from the polymorphisms of Fy125 allele. This report assessed the allele frequency and genotype frequency of Fy(a), Fy(b), Fy(x), and Fy antigens in Koreans. METHODS: We performed a study of the followings on 253 visitors to the health promotion center of Seoul National University Bundang Hospital: PCR-RFLP and PCR-SSP for the detection of Duffy 125G > A and -33T > C; PCR-SSP for the detection of Duffy 265C > T and 298G > A. RESULTS: The results of PCR-RFLP and PCR-SSP were consistent with each other in a total of 253 subjects. Allele frequency was as follows: Fy 92.3%, Fy(125) 6.1%, and fy(125/265) 1.6%. The fy(125/265) allele was newly observed. Fy(125/298), fy(125/265/298), and fy(-33/125) alleles were not detected in Koreans. The distribution of Duffy phenotypes in Koreans was as follows: Fy (a+b-) 88.1%, Fy (a-b+) 0.4%, Fy (a+b+) 11.5%, and Fy (a-b-) 0.0%. Fy (a+) was 99.6% and Fy (b+) was 11.9%. CONCLUSION: In our study for Duffy polymorphisms, the frequency of Fy allele was very high. The frequency was similar to those of other Asian populations, but different from those of Caucasians. The fy(125/265) allele, which was associated with Fy(x) antigen, was newly detected in Koreans.
Alleles* ; Asian Continental Ancestry Group ; Duffy Blood-Group System ; Gene Frequency ; Genotype ; Health Promotion ; Humans ; Phenotype ; Polymerase Chain Reaction ; Seoul

Squamous cell carcinomas arising from the paranasal sinuses are often accompanied by eyeball pain, proptosis, decreased visual acuity and diplopia because of the proximity to the orbit. We report a case of squamous cell carcinoma of maxillary sinus mimicking chronic dacryocystitis and orbital cellulitis due to destruction of lacrimal apparatus.
Carcinoma, Squamous Cell* ; Dacryocystitis ; Diplopia ; Exophthalmos ; Lacrimal Apparatus* ; Maxillary Sinus ; Orbit ; Orbital Cellulitis ; Paranasal Sinuses ; Visual Acuity

To evaluate the realtionship of neural regulation of tear production and autonomic neuropathy, this study was assessed using Schirmer test, tear film break up time and diabetic autonomic neuropathy based on cardiovascular responses. 50 patients were recruited. The results were as follows. The more degree of autonomic neuropathy was present, the less tear production was found. There was a statistically significant difference between mean Schirmer test of normal group with autonomic neuropathy and mean Schirmer test of definitive group with autonomic neuropathy. The more degree of autonomic neuropathy was well correlated with the less tear film break up time. there was no statistically significant difference of mean tear film break up time among 3 groups with autonomic neuropathy. If the definitive group with autonomic neuropathy was screened by Schirmer test, the high sensitivity above 80% was achieved.
Diabetes Mellitus* ; Diabetic Neuropathies ; Humans ; Tears*

To examine the clinical characteristics of ocular emergency in Sungnam, we analyzed 3784 of the eye patients who visited emergency medical center of Inha university hospital during 3 years from January 1, 1995 to December 31, 1997 The ambulation rate of eye patients was 3.97% of total patients visiting emergency medical center and the admission rate was 8.30%. Male was more common than female about 2-fold and the patients in the age of 3rd decade(30.8%) and 4th decade(23.7%) were common Regarding the eye in trouble, there was no significant difference between right eye and left eye. September and autumn were most common month and season and visit rate of Sunday(27.7%) was highest in a week. According to the arrival time at emergency medical center, largest group was between 9 PM and 12 AM and within 1 hour from the onset of disease most patients visit emergency medical center. Most frequent cause of visit was beating by fist and common ocular diseases were conjunctivitis(20.4%), orbital contusion(17.9%) and eyelid laceration(13.9%).
Emergencies* ; Eyelids ; Female ; Gyeonggi-do* ; Humans ; Male ; Orbit ; Seasons ; Walking

We retrospectively surveyed total 628 outpatients(1,256 eyes) of age of 60 or over who visited our department of ophthalmology with review of diagnosis, visiual acuity and associated systemic diseases during 3 years from 1988 to 1990 at the Inha University Hospital. The most prevalent ocular disease was cataract, which was diagnosed in 30.7% of total patients. The other disorders comprised conjunctival diseases(21.5%), retinal disease(18.8%), refractive errors(6.5%), lid and lacrimal diseases(5.7%), corneal diseases(5.1%), vitreous diseases(4.6%), glaucoma(4.0%), optic nerve diseases(0.79%) and uveal diseases(0.79%). The blindess was definded as 0.1 or worse of corrected visual acuity and 28% of examined eyes were conuted as the blindness. Proportion of blindness by causes were as follwed: cataract(56%), corneal diseases(10%), diabetic retinopathy(8%), glaucoma(6%), hypertensive retinopathy(5%) and vitreous diseases(3%). Various systemic diseases were associated with ocular disorders in 24% of total cases. Among them, the most prevalent systemic disease was hypertension, 36%, and diabetes mellitus 30% in next, with the following of respiratory diseases 13%, heart diseases 6%, neurologic diseases 5%, hepatobiliary diseases 5%.
Aged* ; Blindness ; Cataract ; Diabetes Mellitus ; Diagnosis ; Eye Diseases* ; Gyeonggi-do* ; Heart Diseases ; Humans ; Hypertension ; Ophthalmology ; Optic Nerve ; Prevalence* ; Retinaldehyde ; Retrospective Studies ; Visual Acuity